Morphofunctional activity of mast cells in renal cancer is studied on specimens from the center of the tumor, peritumorous zone (with an obligatory fragment of the pseudocapsule), and from renal tissues maximally distant from the tumor. The counts and areas of tumor cells were maximum in the peritumorous zone in comparison with intact kidney tissue and central zone of the tumor. Analysis of correlations revealed a direct correlation between the tumor cell count in the peritumorous zone and some clinical morphological parameters of the tumor (anaplasia degree, size, presence of invasion and metastases, and angiogenesis). The count of mast cells in the renal peritumorous zone inversely correlated with 5-year survival: 100% cumulative 5-year survival in patients with mast cell count <6.7±1.6 per field of view.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bobrov IP, Avdalyan AM, Klimachev VV, Lazarev AF, Gerval’d VYa, Dolgativ AYu, Samuilenkova OV, Kovrigin MV, Kobyakov DS. Modification of a histochemical method for detecting nucleolar organizers on histological sections. Arkh. Patol. 2010;72(3):35-37. Russian.
Lazarev AF, Kobyakov DS, Avdalyan AM, Bychkova EYu, Lushnikova EL, Nepomnyashchikh LM. Apoptostic marker (p53, bcl-2, bax) association with clinical pathologic parameters and survival in non-small cell lung carcinoma. Ross. Onkol. Zh. 2015;20(4):29-30. Russian.
Chan JK, Magistris A, Loizzi V, Lin F, Rutgers J, Osann K, DiSaia PJ, Samoszuk M. Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer. Gynecol. Oncol. 2005;99(1):20-25.
Ch’ng S, Wallis RA, Yuan L, Davis PF, Tan ST. Mast cells and cutaneous malignancies. Mod. Pathol. 2006;19(1):149-159.
Ehara T, Shigematsu H. Mast cell in the kidney. Nephrology. (Carlton). 2003;8(3):130-138.
Johansson A, Rudolfsson S, Hammarsten P, Halin S, Pietras K, Jones J, Stattin P, Egevad L, Granfors T, Wikström P, Bergh A. Mast cell are novel independent prognostic markers in prostate cancer and represent a target therapy. Am. J. Pathol. 2010;177(2):1031-1041.
Ju MJ, Qiu SJ, Gao Q, Fan J, Cai MY, Li YW, Tang ZY. Combination of peritumoral mast cell and T-regulatory cells predicts prognosis of hepatocellular carcinoma. Cancer Sci. 2009;100(7):1267-1274.
Maltby S, Khazaie K, McNagny KM. Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation. Biochim. Biophys. Acta. 2009;1796(1):19-26.
Mohseni MG, Mohammadi A, Heshmat AS, Kosari F, Meysamie AP. The lack of correlation between mast cell and microvessel density with pathologic feature of renal cell carcinoma. Int. Urol. Nephrol. 2010;42(1):109-112.
Sawicki B, Kasacka I, Chyczewski L. Preliminary evaluation of mast cells and angiogenesis processes in experimental fibrosarcoma. Folia Histochem. Cytobiol. 2002;40(2): 197-198.
Tuna B, Yorukoglu K, Unlu M, Mungan MU, Kirkali Z. Association of mast cells with microvessel density in renal cell carcinomas. Eur. Urol. 2006;50(3):530-534.
Woldemeskel M, Rajeev S. Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors. Vet. Res. Commun. 2010;34(2):153-160.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 6, pp. 768-772, June, 2017
Rights and permissions
About this article
Cite this article
Cherdantseva, T.M., Bobrov, I.P., Avdalyan, A.M. et al. Mast Cells in Renal Cancer: Clinical Morphological Correlations and Prognosis. Bull Exp Biol Med 163, 801–804 (2017). https://doi.org/10.1007/s10517-017-3907-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3907-7