Skip to main content
SpringerLink
Log in

Involvement of Autonomic Nervous System in Antiarrhythmic Effect of Intermittent Hypobaric Hypoxia

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the involvement of the autonomic nervous system in the antiarrhythmic effect of intermittent hypobaric hypoxia modeled by daily placing the rats into an altitude chamber at 405 mm Hg (5000 m above sea level). The antiarrhythmic effect of hypoxia was observed on the model of acute coronary occlusion/reperfusion in vivo, but not during simulation of total ischemia/reperfusion of the isolated myocardium. Intravenous injection of ganglionic blocker hexamethonium (30 mg/kg) 15 min prior to in vivo coronary occlusion modeling abolished the antiarrhythmic effect of intermittent hypobaric hypoxia, which suggests that this effect is mediated via activation of the autonomic nervous system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ishekov АN, Mosyagin IG. Dynamics of cardiorespiratory system indices in students during adaptation to atmospheric hypoxic hypoxia in European North of Russia. Ekol. Chel. 2009;(1):38-42. Russian.

    Google Scholar 

  2. Lishmanov YuB, Naryzhnaya NV, Maslov LN, Gross GJ. Opiategic component of the antiarrhythmic effect of adaptation to hypoxia in in vivo model of ischemia and reperfusion. Patol. Fiziol. Eksp. Ter. 2003;(1):19-21. Russian.

    Google Scholar 

  3. Lishmanov IB, Uskina EV, Krylatov AV, Kondrat’ev BI, Ugdyzhekova DS, Maslov LN. Modulation of the antiarrhythmic effect by endogenous opioids during adaptation to hypoxia in rats. Ross. Fiziol. Zh. 1998;84(4):363-372. Russian.

    CAS  Google Scholar 

  4. Maslov LN, Krylatov AV, Lishmanov YuB. Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias: Role of the vegetative nervous system. Bull. Exp. Biol. Med. 1996;122(1):671-673.

    Article  Google Scholar 

  5. Mikhailova SD, Storozhakov GI, Bebyakova NA, Semushkina TM. Role of vagus nerves in antiarrhythmic effect of DAGO in acute myocardial ischemia. Bull. Exp. Biol. Med. 1997;124(4):952-954.

    Article  CAS  Google Scholar 

  6. Boushel R, Calbet JA, Rådegran G, Sondergaard H, Wagner PD, Saltin B. Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude. Circulation. 2001;104(15):1785-1791.

    Article  CAS  PubMed  Google Scholar 

  7. Estrada JA, Barlow MA, Yoshishige D, Williams AG Jr, Downey HF, Mallet RT, Caffrey JL. d-Opioid receptors: pivotal role in intermittent hypoxia-augmentation of cardiac parasympathetic control and plasticity. Auton. Neurosci. 2016;198:38-49.

    CAS  Google Scholar 

  8. Kent KM, Smith ER, Redwood DR, Epstein SE. Electrical stability of acutely ischemic myocardium. Influences of heart rate and vagal stimulation. Circulation. 1973;47(2):291-298.

    Article  CAS  PubMed  Google Scholar 

  9. Laubie M, Schmitt H, Vincent M. Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anaesthetized dogs. Eur. J. Pharmacol. 1979;59(3-4):287-291.

    Article  CAS  PubMed  Google Scholar 

  10. Meerson FZ, Ustinova EE, Orlova EH. Prevention and elimination of heart arrhythmias by adaptation to intermittent high altitude hypoxia. Clin. Cardiol. 1987;10(12):783-789.

    Article  CAS  PubMed  Google Scholar 

  11. Schultz JE, Yao Z, Cavero I, Gross GJ. Glibenclamide-induced blockade of ischemic preconditioning is time dependent in intact rat heart. Am. J. Physiol. 1997;272(6, Pt 2):H2607-H2615.

    CAS  PubMed  Google Scholar 

  12. Wang X, Dergacheva O, Griffioen KJ, Huang ZG, Evans C, Gold A, Bouairi E, Mendelowitz D. Action of kappa and Delta opioid agonists on premotor cardiac vagal neurons in the nucleus ambiguus. Neuroscience. 2004;129(1):235-241.

    Article  CAS  PubMed  Google Scholar 

  13. Wolfe BB, Voelkel NF. Effects of hypoxia on atrial muscarinic cholinergic receptors and cardiac parasympathetic responsiveness. Biochem. Pharmacol. 1983;32(13):1999-2002.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    N. V. Naryzhnaya, A. V. Mukhamedzyanov, T. V. Lasukova & L. N. Maslov

  2. Department of Medical and Biological Sciences, Tomsk State Pedagogical University, Tomsk, Russia

    T. V. Lasukova

Authors
  1. N. V. Naryzhnaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Mukhamedzyanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. V. Lasukova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. N. Maslov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. V. Naryzhnaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 3, pp. 275-278, March, 2017

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Naryzhnaya, N.V., Mukhamedzyanov, A.V., Lasukova, T.V. et al. Involvement of Autonomic Nervous System in Antiarrhythmic Effect of Intermittent Hypobaric Hypoxia. Bull Exp Biol Med 163, 299–301 (2017). https://doi.org/10.1007/s10517-017-3789-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-017-3789-8

Key Words

Search

Navigation