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Associations of Osteocalcin, Osteoprotegerin, and Calcitonin with Inflammation Biomarkers in Atherosclerotic Plaques of Coronary Arteries

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We studied associations of osteocalcin, osteoprotegerin, and calcitonin with markers of inflammation in atherosclerotic plaques in coronary arteries and assessed the influence of these biomolecules on calcification of atherosclerotic plaques. The initial stage of calcification of atherosclerotic plaques is characterized by activation of inflammatory processes, which is seen from increased levels of proinflammatory biomarkers (IL-6, IL 8, TNF-α, and IL-1β). Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin. The exception is osteocalcin, its concentration significantly increased during calcification. The results suggest that severe vascular calcification can be regarded as non-specific marker of atherosclerosis. Instability of atherosclerotic plaques is associated with higher level of calcification.

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Authors and Affiliations

  1. Research Institute of Internal and Preventive Medicine, Novosibirsk, Russia

    Ya. V. Polonskaya, E. V. Kashtanova & Yu. I. Ragino

  2. E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Novosibirsk, Russia

    I. S. Murashov, A. M. Volkov, A. V. Kurguzov & A. M. Chernyavsky

Authors
  1. Ya. V. Polonskaya
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  2. E. V. Kashtanova
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  3. I. S. Murashov
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  4. A. M. Volkov
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  5. A. V. Kurguzov
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  6. A. M. Chernyavsky
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  7. Yu. I. Ragino
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Corresponding author

Correspondence to Ya. V. Polonskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 12, pp. 691-694, December, 2016

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Polonskaya, Y.V., Kashtanova, E.V., Murashov, I.S. et al. Associations of Osteocalcin, Osteoprotegerin, and Calcitonin with Inflammation Biomarkers in Atherosclerotic Plaques of Coronary Arteries. Bull Exp Biol Med 162, 726–729 (2017). https://doi.org/10.1007/s10517-017-3698-x

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  • DOI: https://doi.org/10.1007/s10517-017-3698-x

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