For evaluation of the efficiency of bone substitute, nanostructurized Gamalant-paste-FORTEPlus was placed into a mandibular defect in rats. Bone tissue reparation was evaluated after 30 days by histological methods under a microscope. Use of bone substitute in experimental mandibular defect ensured more complete and rapid restructuring of the bone tissue in comparison with the control (natural healing).
Similar content being viewed by others
References
Bartov MS, Gromov AV, Poponova MS, Savina DM, Nikitin KE, Grunina TM, Manskikh VN, Gra OA, Lunin VG, Karyagina AS, Gintsburg AL. Modern approaches to studies of new osteogenic biomaterials on the model of regeneration of critical-size cranial defects in rats. Bull. Exp. Biol. Med. 2016; 162(2):273-276.
Volozhin AI, Gemonov VV, Desyatnichenko KS, Коroteyev AA, Kurdyumov SG. Experimental evidence of the effectiveness of osteoplastic gel with non-collagenic morphogenetic proteins used to optimize mandibular bone wound healing. Ross. Stomatol. Zh. 2006;(6):4-7. Russian.
Gintsburg AL, Karyakina AS, Lunin VG, Semikhin AS. Development of a new-generation drugs for effective bone regeneration. Lechenie Profilaktika. 2011;(1):80-84. Russian.
Zharkov AV, Losev VF, Doktorov AI, Kholodov SV, Volozhin AI. Development of constructs containing mesenchymal stem cells (MSCs) and polylactide filled with hydroxyapatite. Ross. Vestn. Dental. Implantol. 2007;(3-4):36-41. Russian.
Zaitsev VV, Karyagina AS, Lunin VG. Bone morphogenetic proteins (BMP): general characteristics and prospects of clinical application in traumatology and orthopedics. Vestn. Travmatol. Ortoped. 2009;(4):79-84. Russian.
Kuz’minukh IA. Treatment of radicular cysts of the jaws using optimizers of tissue regeneration. Nizhegorodsk. Med. Zh. 2008;(2):264-266. Russian.
Novikov V. Bone nanotechnologies. Nauka Tekhnologii Rossii. December 20, 2010 [URL: http://strf.ru/material.aspx?CatalogId=222&d_no=35871].
Tarasenko SV, Ershova AM, Ashurko IP, Kolsnichenko IA. The use of composite synthetic osteoplastic material for alveolar ridge augmentation before dental implantation. Ross. Vestn. Dental. Implantol. 2016;(1):39-44. Russian.
Fedorova MZ, Nadezhdin SV, Kolobov YR, Ivanov MB, Pavlov NA, Zubareva EV. Relationship between osteoinductive characteristics of biocomposite material and physicochemical characteristics of coating. Bull. Exp. Biol. Med. 2009;148(5):822-824.
Shaykhaliev AI, Stretskiy GM, Krasnov MS, Rybakova EYu, Tikhonov VE, Arazashvili LD, Gevorkov GL, Yamskova VP, Yamskov IA. Use of materials with bioregulatory peptide complex, affecting osteoreparation process (the results of preclinical tests). Ross. Stomatol. Zh. 2014;(.4):12-16. Russian.
Yaremenko AI, Novikov SV, Mal’kov IA, Tamazov ID. Orthognathic surgery, alveoloplasty, and dental implants in rehabilitation of mastication and speech in patients with reduced jaw bone volume. Ross. Vestn. Dental. Implantol. 2016;(1):45-51. Russian.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 11, pp. 618-620, November, 2016
Rights and permissions
About this article
Cite this article
Olesova, V.N., Amkhadova, M.A., Simakova, T.G. et al. Experimental Validation of the Efficiency of Gamalant-paste-FORTE Plus, a Russian Osteoinductive Material, in Oral Surgery. Bull Exp Biol Med 162, 664–665 (2017). https://doi.org/10.1007/s10517-017-3682-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3682-5