Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing γ-radiation in a dose of 4 Gy and chemoprophylaxis with α-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under conditions of radiation-induced carcinogenesis. Life-time evaluation of toxicogenomic effects was carried out by express method for measurements of blood nucleotid DNA – fluorescent indication. The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. A significant decrease of genotoxicity as a result of drug treatment in comparison with the number and multiplicity of tumors in irradiated animals was found only in the endocrine and reproductive organs of rats treated by eleutherococcus extract.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. A. Aleksandrov and V. G. Bespalov, Vopr. Onkol., 37, No. 4, 387-393 (1991).
O. D. Barnaulov, Ginseng and Other Adaptogens [in Russian], St. Petersburg (2001).
V. G. Bespalov, V. A. Aleksandrov, A. S. Petrov, and D. N. Troyan, Eks. Onkol., 14, No. 2, 26-30 (1992).
V. G. Bespalov, V. A. Aleksandrov, K. V. Yaremenko, et al., Vopr. Onkol., 38, No. 9, 1073-1080 (1992).
V. G. Bespalov, V. A. Aleksandrov, A. L. Semenov, et al., Sib. Onkol. Zh., No. 5, 27-33 (2013).
S. D. Ivanov, E. G. Kovan’ko, V. A. Yashmanov, et al., Bull. Exp. Biol. Med., 140, No. 4, 428-431 (2005).
S. D. Ivanov, V. N. Nikitina, V. A. Yashmanov, et al., Bull. Exp. Biol. Med., 151, No. 1, 38-40 (2011).
S. D. Ivanov, M. P. Sobutsky, A. S. Monakhov, and E. G. Kovan’ko, Toksikol. Vestn., No. 1, 21-25 (2008).
Yu. A. Revazova, Common Toxicology [in Russian], Ed. B. A. Kurlyandskii, Moscow (2002), p. 385-406.
K. V. Yaremenko, Optimal Status of the Organism and Adaptogens [in Russian], St. Petersburg (2008).
S. Bonovas, A. Tsantes, T. Drosos, and N. M. Sitars, Anticancer Res., 28, No. 3B, 1857-1866 (2008).
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 75 (2000).
F. L. Meyskens Jr and E. W. Gerner, Clin. Cancer Res., 5, No. 5, 945-951 (1999).
F. L. Meyskens Jr., C. E. McLaren, D. Pelot, et al., Cancer Prev. Res. (Phila), 1, No. 1, 32-38 (2008).
K. Ozasa, Y. Shimizu, R. Sakata, et al., Radiat. Prot. Dosimetry, 146, Nos. 1-3, 272-275 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 11, pp. 661-665, November, 2015
Rights and permissions
About this article
Cite this article
Ivanov, S.D., Bespalov, V.G., Semenov, A.L. et al. Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis. Bull Exp Biol Med 160, 705–708 (2016). https://doi.org/10.1007/s10517-016-3255-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3255-z