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CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects

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Bulletin of Experimental Biology and Medicine Aims and scope

Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.

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Authors and Affiliations

  1. Research Institute of Mental Health, Tomsk, Russia

    S. A. Ivanova, N. M. Vyalova, I. V. Pozhidaev, D. Z. Osmanova, O. Yu. Fedorenko, A. V. Semke & N. A. Bokhan

  2. Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    M. L. Filipenko & E. N. Voronina

  3. National Research Tomsk Polytechnical University, Tomsk, Russia

    S. A. Ivanova & O. Yu. Fedorenko

  4. National Research Tomsk State University, Tomsk, Russia

    I. V. Pozhidaev, D. Z. Osmanova & N. A. Bokhan

  5. St. Petersburg V. M. Bekhterev Psychoneurological Research Institute, Ministry of Health of the Russian Federation, St. Petersburg, Russia

    M. V. Ivanov

Authors
  1. S. A. Ivanova
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  2. M. L. Filipenko
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  3. N. M. Vyalova
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  4. E. N. Voronina
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  5. I. V. Pozhidaev
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  6. D. Z. Osmanova
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  7. M. V. Ivanov
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  8. O. Yu. Fedorenko
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  9. A. V. Semke
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  10. N. A. Bokhan
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Corresponding author

Correspondence to S. A. Ivanova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 11, pp. 639-643, November, 2015

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Ivanova, S.A., Filipenko, M.L., Vyalova, N.M. et al. CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. Bull Exp Biol Med 160, 687–690 (2016). https://doi.org/10.1007/s10517-016-3250-4

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  • DOI: https://doi.org/10.1007/s10517-016-3250-4

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