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Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development

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Bulletin of Experimental Biology and Medicine Aims and scope

Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD50 and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.

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Authors and Affiliations

  1. Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. V. Bannova

  2. Department of Physiology, Novosibirsk State University, Novosibirsk, Russia

    P. N. Menshanov & N. N. Dygalo

Authors
  1. P. N. Menshanov
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  2. A. V. Bannova
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  3. N. N. Dygalo
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Correspondence to P. N. Menshanov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 460–463, October, 2015

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Menshanov, P.N., Bannova, A.V. & Dygalo, N.N. Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development. Bull Exp Biol Med 160, 459–461 (2016). https://doi.org/10.1007/s10517-016-3196-6

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  • DOI: https://doi.org/10.1007/s10517-016-3196-6

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