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Serum Concentration of Growth Factors in Dogs under Different Conditions of Distraction Osteogenesis

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Bulletin of Experimental Biology and Medicine Aims and scope

Concentrations of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2), stem cell factor (SCF), vascular endothelial growth factor (VEGF), and transforming growth factor β1 (TGF-β1) were measured in the blood serum of dogs subjected to experimental lengthening of shin bones. In animals subjected to shin bone lengthening at a rate of 1 mm/day in 4 steps, the concentrations of SCF and TGF-β1 significantly increased in the middle of distraction and IGF-1 concentration increased by the end of distraction. In animals subjected to lengthening at a rate of 1.5 mm/day in 6 steps, the levels of IGF-1 and TGF-β1 significantly increased in the middle of distraction and the concentration of IGF-2 at the end of distraction. In animals subjected to lengthening at a rate of 3 mm/day in 120 steps, the concentrations of IGF-1 and TGF-β1 significantly decreased in the middle of distraction and concentrations of IGF-1, VEGF, and TGF-β1 increased by the end of distraction.

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Authors and Affiliations

  1. G. A. Ilizarov Russian Research Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation, Kurgan, Russia

    M. V. Stogov, N. V. Tushina & A. A. Emanov

Authors
  1. M. V. Stogov
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  2. N. V. Tushina
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  3. A. A. Emanov
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Correspondence to M. V. Stogov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 8, pp. 175–177, August, 2015

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Stogov, M.V., Tushina, N.V. & Emanov, A.A. Serum Concentration of Growth Factors in Dogs under Different Conditions of Distraction Osteogenesis. Bull Exp Biol Med 160, 213–215 (2015). https://doi.org/10.1007/s10517-015-3131-2

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  • DOI: https://doi.org/10.1007/s10517-015-3131-2

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