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Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes

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Bulletin of Experimental Biology and Medicine Aims and scope

Reaction of the glutathione system of Jurkat tumor cells and blood lymphocytes was evaluated under conditions of culturing with 5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl) isoxazole (KRIBB3), a selective inhibitor of heat shock protein Hsp27. The results indicated the regulatory role of Hsp27 in the maintenance of the functional activities of glutathione reductase, glutathione peroxidase, and realization of apoptotic death of Jurkat cells and blood lymphocytes. Inhibition of Hsp27 in Jurkat tumor cells led to imbalance of the glutathione system and increase of the share of annexin-positive cells.

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Authors and Affiliations

  1. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia

    N. V. Ryazantseva, E. A. Stepovaya, O. L. Nosareva, E. V. Konovalova, D. S. Orlov, A. I. Naumova, S. A. Didenko, O. N. Vesnina, E. V. Shakhristova, A. P. Zima & V. V. Novitskii

  2. National Research Tomsk State University, Tomsk, Russia

    N. V. Ryazantseva, E. A. Stepovaya, O. L. Nosareva, E. V. Konovalova, D. S. Orlov, A. I. Naumova, S. A. Didenko, O. N. Vesnina, E. V. Shakhristova, A. P. Zima & V. V. Novitskii

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  1. N. V. Ryazantseva
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  2. E. A. Stepovaya
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  3. O. L. Nosareva
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  4. E. V. Konovalova
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  5. D. S. Orlov
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  6. A. I. Naumova
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  7. S. A. Didenko
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  8. O. N. Vesnina
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  9. E. V. Shakhristova
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  10. A. P. Zima
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  11. V. V. Novitskii
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Corresponding author

Correspondence to O. L. Nosareva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 9, pp. 366-369, September, 2014

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Ryazantseva, N.V., Stepovaya, E.A., Nosareva, O.L. et al. Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes. Bull Exp Biol Med 158, 377–379 (2015). https://doi.org/10.1007/s10517-015-2766-3

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  • DOI: https://doi.org/10.1007/s10517-015-2766-3

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