Diabetes mellitus was simulated in rats on gestation day 1 by a single intraperitoneal injection of streptozotocin in doses of 40 and 50 mg/kg. Pregnant females showed increased glucose concentrations n the blood and urine, embryonic developmental disorders, such as tongue protrusion, edema, and skin hyperemia with concomitant vascular damage (hemorrhage, hematoma) as well as pre- and post-implantation embryo loss. Afobazole administered orally in doses of 10 and 50 mg/kg to pregnant rats with streptozotocin-induced diabetes significantly decreased prenatal developmental disorders and pre- and post-implantation embryo loss rate. Afobazole in a dose of 50 mg/kg produced maximum protective effect: in rats receiving 40 mg/kg streptozotocin, post-implantation embryo loss decreased by 14.7 times. Afobazole in doses of 10 and 50 mg/kg significantly reduced blood glucose concentration in pregnant rats and normalized glycemia in 90-day-old male offspring.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 7, pp. 20-24, July, 2014
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Zabrodina, V.V., Shreder, E.D., Shreder, O.V. et al. Impaired Prenatal Development and Glycemic Status in the Offspring of Rats with Experimental Streptozotocin-Induced Diabetes and Their Correction with Afobazole. Bull Exp Biol Med 158, 16–20 (2014). https://doi.org/10.1007/s10517-014-2681-z
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DOI: https://doi.org/10.1007/s10517-014-2681-z