A new method for reproduction of metastatic involvement of the liver in outbred albino rats is proposed. The use of the method rules out the effects of stress factors (surgical intervention, total anesthesia) on malignant tumor metastasizing, making it maximally similar to the natural process. The method allows visual evaluation of the time course of the primary tumor node growth. The metastatic involvement of the liver develops only by the most significant route, hematogenic. The method can be used for the development of experimental therapy for this condition.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 6, pp. 745-747, June, 2014
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Kit, O.I., Frantsiyants, E.M., Kaplieva, I.V. et al. A Method for Reproduction of Metastases in the Liver. Bull Exp Biol Med 157, 773–775 (2014). https://doi.org/10.1007/s10517-014-2664-0
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DOI: https://doi.org/10.1007/s10517-014-2664-0