The thermolabile toxin of Yersinia pseudotuberculosis produces a selective dose-dependent stimulating effect on functional activity of innate immunity cells. Prolonged apoptosis-inducing action of the toxin was associated with activation of enzymes of the oxygen-dependent system (LDH and myeloperoxidase) at the early terms of observation (up to 3 h). In turn, increased number of macrophages with apoptotic changes was noted at the early stages of contact with the thermolabile toxin (5 h), and its further growth was observed against the background of activation of mitochondrial enzymes and production of NO metabolites.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 483-487, April, 2014
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Plekhova, N.G., Drobot, E.I., Timchenko, N.F. et al. Effect of Thermolabile Toxin from Yersinia pseudotuberculosis on Functions of Innate Immunity Cells. Bull Exp Biol Med 157, 483–487 (2014). https://doi.org/10.1007/s10517-014-2597-7
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DOI: https://doi.org/10.1007/s10517-014-2597-7