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Semaforin Sema4D in the Immune System in Multiple Sclerosis

  • Immunology and Microbiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The expression of class IV semaforin Sema4D and its CD72 receptor on lymphocytes was studied in patients with multiple sclerosis. The disease was associated with an increase in Sema4D level on intact T lymphocytes and with its more intense shedding from the membrane of activated cell. Multiple sclerosis was also associated with a decrease of CD72 receptor expression by B lymphocytes. Possible contribution of Sema4D to the disease development via the direct effects in the CNS and the immunomodulatory effect, specifi cally, B cell activity regulation, was discussed.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Micro-Organisms, Ural Division of the Russian Academy of Sciences, Perm’, Russia

    E. M. Kuklina & I. V. Nekrasova

  2. E. A. Wagner State Medical Academy, the Ministry of Health of the Russian Federation, Perm’, Russia

    T. V. Baidina & I. Yu. Danchenko

Authors
  1. E. M. Kuklina
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  2. T. V. Baidina
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  3. I. Yu. Danchenko
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  4. I. V. Nekrasova
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Corresponding author

Correspondence to E. M. Kuklina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 198-201, February, 2014

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Kuklina, E.M., Baidina, T.V., Danchenko, I.Y. et al. Semaforin Sema4D in the Immune System in Multiple Sclerosis. Bull Exp Biol Med 157, 234–237 (2014). https://doi.org/10.1007/s10517-014-2533-x

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  • DOI: https://doi.org/10.1007/s10517-014-2533-x

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