Comparative morphological study of the placentas in women with preeclampsia and smallfor-date fetuses was carried out. Expression of insulin-like growth factor-1 (IGF-1), insulinlike growth factor-2 (IGF-2), and insulin-like growth factor binding protein-3 (IGFBP-3) was detected by immunohistochemical methods. Low expression of IGF-1 and high expression of IGF-2 and IGFBP-3 in the placental tissue depending on preeclampsia severity were detected. The most pronounced changes were found in preeclampsia associated with small-for-date fetuses.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
E. A. Dubova, K. A. Pavlov, V. M. Lyapin, et al., Bull. Exp. Biol. Med., 154, No. 6, 792-795 (2013).
K. A. Pavlov, E. A. Dubova, and A. I. Shchyogolev, Akush. Ginekol., No. 3, 11-16 (2011).
G. T. Sukhikh, E. M. Vikhlyaeva, and A. M. Kholin, Ter. Arkh., 81, No. 10, 5-9 (2009).
S. K. Akram, L. Sahlin, and E. Ostlund, Horm. Res. Pediatr., 75, No. 2, 131-137 (2011).
B. Börzsönyi, C. Demendi, Z. Nagy, et al., J. Perinat. Med., 39, No. 6, 701-707 (2011).
M. Constancia, M. Hemberger, J. Hughes, et al., Nature, 417, 945-948 (2002).
K. Forbes, B. Souquet, R. Garside, et al., Endocrinology, 151, No. 4, 1723-1731 (2010).
R. M. Kimble, B. H. Breier, P. D. Gluckman, and J. E. Harding, J. Endocrinol., 162, No. 2, 227-235 (1999).
L. Laviola, S. Perrini, G. Belsanti, Endocrinology, 146, No. 3, 1498-1505 (2005).
M. H. Lee, Y. J. Jeon, S. M. Lee, et al., Early Hum. Dev., 86, No. 1, 45-50 (2010).
K. C. Leung and K. K. Ho, Clin. Chim. Acta, 313, Nos. 1-3, 119-123 (2001).
J. P. Liu, J. Baker, A. S. Perkins, Cell, 75, No. 1, 59-72 (1993).
S. Ozkan, B. Vural, S. Filiz, et al., J. Matern. Fetal Neonatal Med., 21, No. 11, 831-838 (2008).
L. J. Vatten, R. A. Odegard, S. T. Nilsen, et al., Obstet. Gynecol., 99, No. 1, 85-90 (2002).
K. A. Woods, C. Camacho-Hubner, M. O. Savage, and A. J. Clark, N. Engl. J. Med., 335, No. 18, 1363-1367 (1996).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 1, pp. 116-120, January, 2014
Rights and permissions
About this article
Cite this article
Dubova, E.A., Pavlov, K.A., Lyapin, V.M. et al. Expression of Insulin-Like Growth Factors in the Placenta in Preeclampsia. Bull Exp Biol Med 157, 103–107 (2014). https://doi.org/10.1007/s10517-014-2502-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-014-2502-4