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Molecular mechanisms of cell death in bronchopulmonary dysplasia

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Abstract

Bronchopulmonary dysplasia (BPD) in neonates is the most common pulmonary disease that causes neonatal mortality, has complex pathogenesis, and lacks effective treatment. It is associated with chronic obstructive pulmonary disease, pulmonary hypertension, and right ventricular hypertrophy. The occurrence and development of BPD involve various factors, of which premature birth is the most crucial reason for BPD. Under the premise of abnormal lung structure and functional product, newborns are susceptible to damage to oxides, free radicals, hypoxia, infections and so on. The most influential is oxidative stress, which induces cell death in different ways when the oxidative stress balance in the body is disrupted. Increasing evidence has shown that programmed cell death (PCD), including apoptosis, necrosis, autophagy, and ferroptosis, plays a significant role in the molecular and biological mechanisms of BPD and the further development of the disease. Understanding the mode of PCD and its signaling pathways can provide new therapeutic approaches and targets for the clinical treatment of BPD. This review elucidates the mechanism of BPD, focusing on the multiple types of PCD in BPD and their molecular mechanisms, which are mainly based on experimental results obtained in rodents.

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Data availability

The data used for graphing in this review are all from references.

Abbreviations

FADD:

Fas-associated via death domain

RIPK3:

Receptor-interacting serine-threonine kinase 3

RIPK1:

Receptor-interacting serine-threonine kinase 1

NF-κB:

Nuclear factor kappa-B

TSG-6:

Tumor necrosis factor α stimulated gene 6

ERK:

Extracellular regulated protein kinases

JNK:

C-Jun N-terminal kinase

BCL-2:

B-cell lymphoma-2

SIRT1:

Sirtuin 1

SENP1:

SUMO-specific proteases 1

PI3K:

PhosphoInositide-3 Kinase

AKT:

Protein Kinase B

Keap1:

Kelch-like ECH-associated protein1

Nrf2:

Nuclear factor E2-related factor 2

ARE:

AU-rich element

DLL4:

Delta-like ligand4

ROS:

Reactive oxygen species

MLKL:

Mixed Lineage Kinase Domain-Like (protein)

PDC:

Pyruvate dehydrogenase complex

AMPK:

AMP-activated protein kinase

NLRP3:

NOD-like receptor thermal protein domain associated protein 3

GSDMD:

Gasdermin D

GSH:

Glutathione

GPX4:

Glutathione Peroxidase 4

Cys:

Cysteine

SLC7A11:

Recombinant Solute Carrier Family 7, Member 11

SLC3A2:

Recombinant Solute Carrier Family 3, Member 2

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Acknowledgements

We would like to thank Editage (www.editage.cn) for English language editing.

Funding

This research was supported by the National Natural Science Foundation of China (No. 82101812), the Jiangsu Commission of Health and Family Planning (No. Z2020042 and No. SFY202105), Wuxi Municipal Medical Innovation Team (No. CXTD2021013), and the Wuxi Young and Middle-aged Medical Talents Project (No. BJ2020075 and No. BJ2020079).

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  1. Xianhui Deng and Zhidan Bao have contributed equally to this work.

Authors and Affiliations

  1. Department of Neonatology, Wuxi Maternity and Child Health Care Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, China

    Xianhui Deng, Xianpeng Yang, Yingzi Mei, Qin Zhou & Renqiang Yu

  2. Department of Neonatology, Jiangyin People’s Hospital of Nantong University, Wuxi, China

    Zhidan Bao

  3. Translational Medicine Laboratory, Research Institute for Reproductive Health and Genetic Diseases, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China

    Ailing Chen

  4. Department of Neonatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Yongjun Zhang

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Contributions

XD and ZB were responsible for data collection and the writing of the original manuscript. XY, YM, and QZ were responsible for the editing. AC and YZ are responsible for concept development and revision. RY was responsible for concept development, review of the manuscript, revision and funding acquisition. All authors have contributed to the manuscript and approved the submitted version.

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Correspondence to Ailing Chen, Renqiang Yu or Yongjun Zhang.

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Deng, X., Bao, Z., Yang, X. et al. Molecular mechanisms of cell death in bronchopulmonary dysplasia. Apoptosis 28, 39–54 (2023). https://doi.org/10.1007/s10495-022-01791-4

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