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Mechanisms of monocyte cell death triggered by dengue virus infection

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Abstract

Arthropod-borne viral diseases caused by dengue virus (DENV) are major re-emerging public health problem worldwide. In spite of intense research, DENV pathogenesis is not fully understood and remains enigmatic; however, current evidence suggests that dengue progression is associated with an inflammatory response, mainly in patients suffering from a second DENV infection. Monocytes are one of the main target cells of DENV infection and play an important role in pathogenesis since they are known to produce several inflammatory cytokines that can lead to endothelial dysfunction and therefore vascular leak. In addition, monocytes play an important role in antibody dependent enhancement, infection with consequences in viral load and immune response. Despite the physiological functions of monocytes in immune response, their life span in the bloodstream is very short, and activation of monocytes by DENV infection can trigger different types of cell death. For example, DENV can induce apoptosis in monocytes related with the production of Tumor necrosis factor alpha (TNF-α). Additionally, recent studies have shown that DENV-infected monocytes also exhibit a cell death process mediated by caspase-1 activation together with IL-1 production, referred to as pyroptosis. Taken together, the aforementioned studies strongly depict that multiple cell death pathways may be occurring in monocytes upon DENV-2 infection. This review provides insight into mechanisms of DENV-induced death of both monocytes and other cell types for a better understanding of this process. Further knowledge in cell death induced by DENV will help in the developing novel strategies to prevent disease progression.

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Acknowledgements

The authors acknowledge the help of Anne-Lise Haenni for their critical reading and review of the manuscript and Universidad de Antioquia, UdeA.

Funding

The authors hereby disclose receipt of the following financial support for the research, authorship, and/or publication of this article. This study was funded by Universidad de Antioquia, UdeA. The funders had no role in the study design, data collection and analysis, manuscript preparation or the decision to publish.

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  1. Grupo Inmunovirología, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, UdeA, Calle 70 No 52-21, Medellín, Colombia

    Jorge Andrés Castillo & Silvio Urcuqui-Inchima

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  1. Jorge Andrés Castillo
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  2. Silvio Urcuqui-Inchima
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Correspondence to Silvio Urcuqui-Inchima.

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Castillo, J.A., Urcuqui-Inchima, S. Mechanisms of monocyte cell death triggered by dengue virus infection. Apoptosis 23, 576–586 (2018). https://doi.org/10.1007/s10495-018-1488-1

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