Abstract
Tenofovir diphosphate (TVF-DP) can be quantified in red blood cells (RBCs) and dried blood spots (DBS) and can objectively measure ART adherence and predict viral suppression. Data on the association of TFV-DP with viral load are very limited in adolescents and young adults (AYA) living with perinatally-acquired HIV (PHIV), as are data comparing TFV-DP to other measures of ART adherence, such as self-report and unannounced telephone pill count. Viral load and ART adherence (self-report, TFV-DP and unannounced telephone pill count) were assessed and compared among 61 AYAPHIV recruited from an ongoing longitudinal study (CASAH) in New York City.
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The datasets generated and/or analyzed for preparation of this manuscript are available from the corresponding author on reasonable request.
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Funding
This research was supported by the National Institute of Mental Health (R01 MH069133 PI Mellins; P30 MH043520 PI Remien; and T32 MH19139 PI Sandfort).
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RNR, LK, and NN wrote a first draft of the manuscript. LK performed the research. CAM, EJA, AW, and CD designed the research study. CD managed the data. CSL analyzed the data. AW, EJA, PLA, and JRC-M provided critical comments and insight. All authors contributed to interpreting the results, reviewing and revising, and all authors have approved the final manuscript.
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Robbins, R.N., Kluisza, L., Nguyen, N. et al. Measuring ART Adherence Among Young Adults with Perinatally Acquired HIV: Comparison Between Self-report, Telephone-Based Pill Count, and Objective Pharmacologic Measures. AIDS Behav 27, 3927–3931 (2023). https://doi.org/10.1007/s10461-023-04107-y
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DOI: https://doi.org/10.1007/s10461-023-04107-y