Abstract
The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with VL data (Brazil = 146; Thailand = 159). Generalized linear mixed models (GLMM) assessed whether non-injection substance use (stimulants, cannabis, alcohol, polysubstance) was associated with VL undetectability. ART adherence and depressive symptoms were examined as mediators of the association. In Thailand, substance use was not significantly associated with VL undetectability or ART adherence, but alcohol misuse among MSM was associated with increased odds of depression (AOR = 2.75; 95% CI 1.20, 6.32, p = 0.02). In Brazil, alcohol misuse by MSM was associated with decreased odds of undetectable VL (AOR = 0.34; 95% CI 0.13, 0.92, p = 0.03). Polysubstance use by heterosexual men in Brazil was associated with decreased odds of ART adherence (AOR = 0.25; 95% CI 0.08, 0.78, p = 0.02). VL suppression appears attainable among non-injection substance users. Substance use interventions among HIV-positive men should address depression, adherence, and VL undetectability.
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Acknowledgements
The authors would like to thank Dr. Steve Shoptaw as HPTN Scholar mentor (P30 MH058107); HPTN 063 Study Participants and Protocol Team Members; the Fred Hutchinson Cancer Research Center; and Noor A. Al-Alusi for her help designing the manuscript’s figure. This study was supported by NIAID, NIDA, and NIMH under cooperative agreement #UM1 AI068619 as part of the HPTN Scholars Program. Dr. Kiyomi Tsuyuki was supported by NIDA (T32 DA023356); NICHD (R01 HD077891-04S1); and NIAAA (K01AA025009); Dr. Yusuf Ransome supported by NIMH (K01MH111374); Dr. Steven A. Safren was supported by NIDA (9K24DA040489). The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the HIV Prevention Trials Network.
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Tsuyuki, K., Shoptaw, S.J., Ransome, Y. et al. The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063). AIDS Behav 23, 649–660 (2019). https://doi.org/10.1007/s10461-019-02415-w
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DOI: https://doi.org/10.1007/s10461-019-02415-w