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Optimization of the IntraVascular Oxygenator Catheter Using Angular Oscillation

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Abstract

We demonstrate a methodology which both improves oxygen transport and reduces or eliminates bubble formation in a novel hyperbaric membrane oxygenator catheter model system. Angular oscillations were introduced to a bundle of hollow fiber membranes (HFMs) supplied with hyperbaric 100% oxygen at average gauge pressures up to 0.35 barg. Oscillating bundles enabled delivery of an oxygen flux of up to 400 mL min−1 m−2 in an aqueous solution, a doubling over a previous non-oscillating setup. Similarly, the addition of angular oscillations facilitated a five-fold reduction in pressure to achieve similar oxygen flux. The increased angular speed of oscillation improved flux, while the addition of angular micro-oscillation variations resulted in flux reductions of 7–20% compared to continuous macro-oscillation only, depending on mixing conditions. However, semi-quantitative visual observation demonstrated that angular oscillations reduced or eliminated the instance of oxygen bubble formation on the HFMs. The modeled mass transfer coefficients indicated a quasi linear relationship between rotational velocity and flux, suggesting that faster oscillation speeds could further improve oxygen mass transport allowing for HFM bundles to maintain high oxygen fluxes while eliminating bubble formation. This encourages further development of our compact oxygenating catheter that could be used intravascularly.

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Acknowledgments

This study was supported by the Duke Medicine and Engineering (MEDx), National Institute of Child Health and Human Development (Grant/Award Number: T32HD094671) and by the Robert R. Jones Plastic Surgery Research Fund. Many thanks to Dr. Alex Rotta (Duke Pediatrics) for support and insightful discussions.

Funding

This study was funded by Duke Medicine and Engineering (MEDx), the National Institute of Child Health and Human Development (Grant No. T32HD094671), and School of Medicine, Duke University.

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Authors and Affiliations

  1. Department of Civil & Environmental Engineering, Duke University, Durham, NC, USA

    Stewart Farling & Marc A. Deshusses

  2. Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA

    Travis P. Vesel & Tobias L. Straube

  3. Kenan Plastic Surgery Research Labs, Duke University School of Medicine, Durham, NC, USA

    Bruce Klitzman

  4. Department of Biomedical Engineering, Duke University, Durham, NC, USA

    Bruce Klitzman

  5. Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

    Ira M. Cheifetz

  6. Duke Global Health Institute, Duke University, Durham, NC, USA

    Marc A. Deshusses

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  1. Stewart Farling
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  2. Bruce Klitzman
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  3. Travis P. Vesel
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  4. Ira M. Cheifetz
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  5. Tobias L. Straube
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  6. Marc A. Deshusses
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Corresponding author

Correspondence to Marc A. Deshusses.

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Conflict of interest

The authors have a filed a patent application on some aspects of intravascular blood oxygenation described in the submitted manuscript. U.S. Patent Application No.: 17/962,966; Intravascular Membrane Oxygenator Catheter with Oscillating Hollow Fiber Membranes. Filing Date: October 10, 2022.

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Associate Editor Eric M. Darling oversaw the review of this article.

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Farling, S., Klitzman, B., Vesel, T.P. et al. Optimization of the IntraVascular Oxygenator Catheter Using Angular Oscillation. Ann Biomed Eng 52, 638–646 (2024). https://doi.org/10.1007/s10439-023-03411-x

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  • DOI: https://doi.org/10.1007/s10439-023-03411-x

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