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Hemodynamic Evaluation of Asynchronous Speed Modulation of a Continuous-Flow Left Ventricular Assist Device in an Acute-Myocardial Injury Sheep Model

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Abstract

Asynchronous rotational-speed modulation of a continuous-flow left ventricular assist device (LVAD) can increase pulsatility; however, the feasibility of hemodynamic modification by asynchronous modulation of an LVAD has not been sufficiently verified. We evaluated the acute effect of an asynchronous-modulation mode under LVAD support and the accumulated effect of 6 consecutive hours of driving by the asynchronous-modulation mode on hemodynamics, including both ventricles, in a coronary microembolization-induced acute-myocardial injury sheep model. We evaluated 5-min LVAD-support hemodynamics, including biventricular parameters, by switching modes from constant-speed to asynchronous-modulation in the same animals (“acute-effect evaluation under LVAD support”). To determine the accumulated effect of a certain driving period, we evaluated hemodynamics including biventricular parameters after weaning from 6-hour (6 h) LVAD support by constant-speed or asynchronous-modulation mode (“6h-effect evaluation”). The acute-effect evaluation under LVAD support revealed that, compared to the constant-speed mode, the asynchronous-modulation mode increased vascular pulsatility but did not have significantly different effects on hemodynamics, including both ventricles. The 6 h-effect evaluation revealed that the hemodynamics did not differ significantly between the two groups except for some biventricular parameters which did not indicate negative effects of the asynchronous-modulation mode on both ventricles. The asynchronous-modulation mode could be feasible to increase vascular pulsatility without causing negative effects on hemodynamics including both ventricles. Compared to the constant-speed mode, the asynchronous-modulation mode increased pulsatility during LVAD support without negative effects on hemodynamics including both ventricles in the acute phase. Six hours of LVAD support with the asynchronous-modulation mode exerted no negative effects on hemodynamics, including both ventricles, after weaning from the LVAD.

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Acknowledgements

This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number JP21K08853 and Nipro Corporation. We would like to thank KN International and Editage for English proofreading.

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Authors and Affiliations

  1. Department of Artificial Organs, National Cerebral and Cardiovascular Center, 6-1 Kishibeshinmachi, Suita, Osaka, 564-8565, Japan

    Shun Tanaka, Tomohiro Nishinaka, Akihide Umeki, Takashi Murakami, Shusuke Imaoka, Toshihide Mizuno & Tomonori Tsukiya

  2. Department of Cardiac Surgery, The University of Tokyo, 7-3-1, Hongo, Bunkyo , Tokyo, 113-8654, Japan

    Minoru Ono

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  1. Shun Tanaka
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  2. Tomohiro Nishinaka
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  3. Akihide Umeki
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Contributions

ST, TN, AU, TT, TM, and MO substantially contributed to the study’s conception and design. ST, TN, AU, TM, SI, TM, and TT contributed to the data acquisition. All authors contributed to the data analysis and interpretation. ST drafted the manuscript, and all authors revised it. All authors approved the final version of the manuscript.

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Correspondence to Shun Tanaka.

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Conflict of interest

Tomohiro Nishinaka reports collaborative research agreements with Nipro Corporation and Senko Medical Instrument Mfg. Co., Ltd. The other authors have no conflicts of interest to declare.

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Associate Editor Ender A. Finol oversaw the review of this article.

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Tanaka, S., Nishinaka, T., Umeki, A. et al. Hemodynamic Evaluation of Asynchronous Speed Modulation of a Continuous-Flow Left Ventricular Assist Device in an Acute-Myocardial Injury Sheep Model. Ann Biomed Eng 52, 364–375 (2024). https://doi.org/10.1007/s10439-023-03383-y

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