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Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future

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Abstract

As the first section of a multi-part review series, this section provides an overview of the ongoing research and development aimed at fabricating novel heart valve replacements beyond what is currently available for patients. Here we discuss heart valve replacement options that involve a biological component or process for creation, either in vitro or in vivo (tissue-engineered heart valves), and heart valves that are fabricated from polymeric material that are considered permanent inert materials that may suffice for adults where growth is not required. Polymeric materials provide opportunities for cost-effective heart valves that can be more easily manufactured and can be easily integrated with artificial heart and ventricular assist device technologies. Tissue engineered heart valves show promise as a regenerative patient specific model that could be the future of all valve replacement. Because tissue-engineered heart valves depend on cells for their creation, understanding how cells sense and respond to chemical and physical stimuli in their microenvironment is critical and therefore, is also reviewed.

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Acknowledgment

This review article was prepared after the Mathematics Guiding Bioartificial Heart Valve Design meeting held at the Ohio State University, October 28–31, 2013. The authors would like to acknowledge the Mathematical Biosciences Institute and its grant from National Science Foundation (DMS 0931642) that facilitated the meeting.

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Authors and Affiliations

  1. Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA

    Arash Kheradvar, Elliott M. Groves, S. Hamed Alavi & Ahmad Falahatpisheh

  2. Department of Internal Medicine, Division of Cardiology, University of California, Irvine School of Medicine, Irvine, CA, USA

    Arash Kheradvar & Elliott M. Groves

  3. Department of Mechanical Engineering, School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA

    Lakshmi P. Dasi

  4. Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA

    Robert Tranquillo

  5. Department of Bioengineering, Rice University, Houston, TX, USA

    K. Jane Grande-Allen

  6. Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, ON, Canada

    Craig A. Simmons

  7. Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada

    Craig A. Simmons

  8. Department of Mathematics, Center for Interdisciplinary Applied Mathematics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Boyce Griffith

  9. McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA

    Boyce Griffith

  10. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA

    Craig J. Goergen

  11. Department of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA, USA

    Mohammad R. K. Mofrad

  12. Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

    Frank Baaijens

  13. Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA

    Stephen H. Little

  14. Department of Mathematics, University of Houston, Houston, TX, USA

    Suncica Canic

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  1. Arash Kheradvar
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  2. Elliott M. Groves
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  9. Ahmad Falahatpisheh
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  14. Suncica Canic
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Corresponding author

Correspondence to Arash Kheradvar.

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Associate Editor Estefanía Peña oversaw the review of this article.

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Kheradvar, A., Groves, E.M., Dasi, L.P. et al. Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future. Ann Biomed Eng 43, 833–843 (2015). https://doi.org/10.1007/s10439-014-1209-z

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  • DOI: https://doi.org/10.1007/s10439-014-1209-z

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