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FEA Study on the Stress Distributions in the Polymer Coatings of Cardiovascular Drug-Eluting Stent Medical Devices

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Abstract

Cardiovascular drug-eluting stents (DES) are widely applied medical products to treat diseased narrowed arteries. Despite their wide application, there still are many clinical adverse effects associated with DES implantation. One of the major issues is that the coatings comprised of drug and polymer phases are often delaminated during the deployment of the stent, which can lead to more serious clinical complications. In the present work, we conducted a 3D finite-element analysis (FEA) computational study to quantitatively estimate the stress distributions in the coating components of DES devices. To adequately represent the skeleton design of modern DES products, we adopted the strut geometry of a SYNERGY stent along with a full coating of poly(lactic-co-glycolic) acid. The FEA computation results clearly indicate that the curved regions (i.e., kink) are subject to much higher stress accumulation in the coating. In addition, it was found that the local shear and normal stress distribution profiles in the polymer coatings are different from those based on von-Mises stresses near the kink area.

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Acknowledgments

This work was primarily supported by the Catalyst grant program through University of Wisconsin-Milwaukee Research Foundation (UWMRF). The authors wish to thank Ismail Guler and Dr. Steve Kangas at Boston Scientific Corp. for helpful communications for this work.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA

    Solki Lee & Chang-Soo Kim

  2. Department of Chemical Engineering, College of Engineering, Kyung Hee University, 1732 Deogyeong-daero, Gihung, Yongin, Gyeonggi, 446-701, South Korea

    Chang Woo Lee

Authors
  1. Solki Lee
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  2. Chang Woo Lee
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Correspondence to Chang-Soo Kim.

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Associate Editor Peter E. McHugh oversaw the review of this article.

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Lee, S., Lee, C.W. & Kim, CS. FEA Study on the Stress Distributions in the Polymer Coatings of Cardiovascular Drug-Eluting Stent Medical Devices. Ann Biomed Eng 42, 1952–1965 (2014). https://doi.org/10.1007/s10439-014-1047-z

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  • DOI: https://doi.org/10.1007/s10439-014-1047-z

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