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Combined effects of fluid type and particle shape on particles flow in microfluidic platforms

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Abstract

Recent numerical analyses to optimize the design of microfluidic devices for more effective entrapment or segregation of surrogate circulating tumor cells (CTCs) from healthy cells have been reported in the literature without concurrently accommodating the non-Newtonian nature of the body fluid and the non-uniform geometric shapes of the CTCs. Through a series of two-dimensional proof-of-concept simulations with increased levels of complexity (e.g., number of particles, inline obstacles), we investigated the validity of the assumptions of the Newtonian fluid behavior for pseudoplastic fluids and the circular particle shape for different-shaped particles (DSPs) in the context of microfluidics-facilitated shape-based segregation of particles. Simulations with a single DSP revealed that even in the absence of internal geometric complexities of a microfluidics channel, the aforementioned assumptions led to 0.11–0.21W (W is the channel length) errors in lateral displacements of DSPs, up to 3–20\(\%\) errors in their velocities, and 3–5\(\%\) errors in their travel times. When these assumptions were applied in simulations involving multiple DSPs in inertial microfluidics with inline obstacles, errors in the lateral displacements of DSPs were as high as 0.78W and in their travel times up to 23\(\%\), which led to different (un)symmetric flow and segregation patterns of DSPs. Thus, the fluid type and particle shape should be included in numerical models and experiments to assess the performance of microfluidics for targeted cell (e.g., CTCs) harvesting.

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Acknowledgements

Funding for this research was provided by Southwest Research Institute’s Internal Research and Development Program, 18R-8602 and 15R-8651. SS kindly acknowledges funding from the European Research Council under the European Union’s Horizon 2020 Framework Programme (No. FP/2014- 2020)/ERC Grant Agreement No. 739964 (COPMAT).

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  1. Hakan Başağaoğlu

    Present address: Edwards Aquifer Authority, San Antonio, TX, 78215, USA

Authors and Affiliations

  1. Mechanical Engineering Division, Southwest Research Institute, San Antonio, TX, 78238, USA

    Hakan Başağaoğlu & Christopher J. Freitas

  2. Defense Intelligence Solutions Division, Southwest Research Institute, San Antonio, TX, 78238, USA

    Justin Blount

  3. Fondazione Istituto Italiano di Tecnologia, Center for Life Nanoscience at la Sapienza, Rome, vle Regina Margherita, 00165, Rome, Italy

    Sauro Succi

  4. Istituto Applicazioni del Calcolo, Via dei Taurini 19, 00185, Rome, Italy

    Sauro Succi

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  1. Hakan Başağaoğlu
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Correspondence to Hakan Başağaoğlu.

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This article is part of the topical collection “Particle motion in non-Newtonian microfluidics” guest edited by Xiangchun Xuan and Gaetano D’Avino.

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Başağaoğlu, H., Blount, J., Succi, S. et al. Combined effects of fluid type and particle shape on particles flow in microfluidic platforms. Microfluid Nanofluid 23, 84 (2019). https://doi.org/10.1007/s10404-019-2251-9

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