Abstract
Purpose
To introduce a new diagnostic parameter: the linear combination of apparent integrated backscatter and spectral centroid shift.
Methods
Ultrasonic backscatter measurements were performed at the calcanei of 1262 volunteers in vivo. The hip and spine bone mineral densities of the volunteers were measured using dual X-ray absorptiometry. The apparent integrated backscatter and spectral centroid shift were calculated. A new diagnostic parameter, i.e., the linear combination of apparent integrated backscatter and spectral centroid shift, was introduced and its correlation to bone mineral density was analyzed.
Results
The results show that the combination of apparent integrated backscatter and spectral centroid shift is significantly correlated to bone mineral density (R = 0.73–0.84, n = 1262, p < 0.05), and that this correlation is more significant than the correlation between the apparent integrated backscatter and bone mineral density or the correlation between spectral centroid shift and bone mineral density (R = 0.48–0.69, p < 0.05).
Conclusion
The combination of apparent integrated backscatter and spectral centroid shift can provide the complementary information of attenuation of the two parameters and predict more information about cancellous bone, and may be employed to assess cancellous bone status.
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Acknowledgments
This study was supported by the NSFC (11174060, 11327405), the Science and Technology Support Program of Shanghai (13441901900), and the Ph.D. Programs Foundation of the Ministry of Education of China (20130071110020).
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.
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Tang, T., Liu, C., Xu, F. et al. Correlation between the combination of apparent integrated backscatter–spectral centroid shift and bone mineral density. J Med Ultrasonics 43, 167–173 (2016). https://doi.org/10.1007/s10396-015-0690-9
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DOI: https://doi.org/10.1007/s10396-015-0690-9