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A rare case of fungal endocarditis caused by Candida glabrata after completion of antibiotic therapy for Streptococcus endocarditis

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Abstract

We present the rare case of a 76-year-old female with infective endocarditis (IE) caused by Candida glabrata. Immediately before developing the present infection, she developed IE with vegetation on the mitral annular calcification, which was caused by Streptococcus mitis and successfully treated with penicillin-G and gentamicin. However, her fever recurred, and she developed disseminated intravascular coagulation. Blood culture revealed C. glabrata, and echocardiography revealed new vegetation on the mitral valve. After 4 weeks of treatment with micafungin, prosthetic valve replacement was performed, followed by additional administration of micafungin for 4 weeks (total of 8 weeks). No relapse at 9 months after surgery has been observed. C. glabrata endocarditis is extremely rare and difficult to manage. Our case and review of past reported cases suggest that early diagnosis and initiation of treatment contribute to good prognosis of C. glabrata endocarditis.

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Conflict of interest

None.

Ethical statement

Human rights statement and informed consent: This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Cardiology, School of Medicine, Keio University, Tokyo, Japan

    Toshimitsu Tsugu & Keiichi Fukuda

  2. Department of Cardiology, Hino Municipal Hospital, 4-3-1, Tamadaira, Hino, Tokyo, 191-0062, Japan

    Toshimitsu Tsugu & Soushin Inoue

  3. Department of Laboratory Medicine, School of Medicine, Keio University, Tokyo, Japan

    Mitsushige Murata

  4. Department of Cardiology, Saitama International Medical Center, Saitama, Japan

    Shiro Iwanaga

  5. Department of Neurosurgery, Hino Municipal Hospital, Tokyo, Japan

    Yohei Kitamura

Authors
  1. Toshimitsu Tsugu
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  2. Mitsushige Murata
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  3. Shiro Iwanaga
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  4. Yohei Kitamura
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  5. Soushin Inoue
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  6. Keiichi Fukuda
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Corresponding author

Correspondence to Toshimitsu Tsugu.

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Tsugu, T., Murata, M., Iwanaga, S. et al. A rare case of fungal endocarditis caused by Candida glabrata after completion of antibiotic therapy for Streptococcus endocarditis. J Med Ultrasonics 42, 243–246 (2015). https://doi.org/10.1007/s10396-014-0580-6

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  • DOI: https://doi.org/10.1007/s10396-014-0580-6

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