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Antimicrobial-Resistant Bacteria Carriage in Rodents According to Habitat Anthropization

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Abstract

It is increasingly suggested that the dynamics of antimicrobial-resistant bacteria in the wild are mostly anthropogenically driven, but the spatial and temporal scales at which these phenomena occur in landscapes are only partially understood. Here, we explore this topic by studying antimicrobial resistance in the commensal bacteria from micromammals sampled at 12 sites from a large heterogenous landscape (the Carmargue area, Rhone Delta) along a gradient of anthropization: natural reserves, rural areas, towns, and sewage-water treatment plants. There was a positive relationship between the frequency of antimicrobial-resistant bacteria and the level of habitat anthropization. Although low, antimicrobial resistance was also present in natural reserves, even in the oldest one, founded in 1954. This study is one of the first to support the idea that rodents in human-altered habitats are important components of the environmental pool of resistance to clinically relevant antimicrobials and also that a “One Health” approach is required to assess issues related to antimicrobial resistance dynamics in anthropized landscapes.

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Acknowledgements

We would like to thank the owners and managers of the different capture sites for allowing us to conduct our study, in particular the regional nature reserve of Scamandre, the ornithological park of Pont de Gau and the ACCM Eau. We would also like to thank the MAVA foundation and the ECOSAN program of INEE-CNRS for their financial support.

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  1. Patrick Durand and Frédéric Thomas have contributed equally to this work.

Authors and Affiliations

  1. Tour du Valat, Research Institute for the Conservation of Mediterranean Wetlands, Arles, France

    Marion Vittecoq, Thomas Blanchon & François Roux

  2. Laboratory Mivegec, CNRS, IRD UMR5290, CREES, University Montpellier, Montpellier, France

    Eric Elguero, Lionel Brazier, François Renaud, Patrick Durand & Frédéric Thomas

  3. SYNLAB Midi, Parc 2000, 127 Rue Maurice Béjart, 34080, Montpellier, France

    Nicolas Renaud

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  1. Marion Vittecoq
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Correspondence to Marion Vittecoq.

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Vittecoq, M., Elguero, E., Brazier, L. et al. Antimicrobial-Resistant Bacteria Carriage in Rodents According to Habitat Anthropization. EcoHealth 20, 84–92 (2023). https://doi.org/10.1007/s10393-023-01638-7

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