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A retrospective study of definitive chemoradiotherapy in patients with resectable small cell neuroendocrine carcinoma of the esophagus

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Abstract

Background

Standard treatment for resectable small cell neuroendocrine carcinoma of the esophagus (SCNEC-E) remains to be established.

Methods

We retrospectively studied 7 consecutive patients with resectable SCNEC-E who received definitive chemoradiotherapy (dCRT) to evaluate the safety and efficacy. Treatment consisted of two courses of chemotherapy with cisplatin (80 mg/m2 on day 1) and etoposide (100 mg/m2 on days 1–3) or carboplatin (AUC 5 on day 1) and etoposide (80 mg/m2 on days 1–3) given every 4 weeks during dCRT. The total radiation dose was 50.4 Gy (28 fractions).

Results

The clinical stage was IA in 1 patient, IB in 2 patients, IIA in 3 patients, and IIB in 1 patient. Definitive CRT was completed in all patients. The median overall treatment time of radiotherapy was 44 days. The chemotherapy regimen included in dCRT was cisplatin and etoposide in 3 patients and carboplatin and etoposide in 4 patients. Acute adverse events of grade 3 or 4 were neutropenia 100%, thrombocytopenia 43%, febrile neutropenia 43%, and nausea 14%. There were no late grade 3 or 4 adverse events. The median survival time was 32 months. The complete response rate was 100%. The recurrence rate was 43%. The median survival of the 4 patients without recurrence was 56 months.

Conclusions

Definitive CRT with cisplatin and etoposide or carboplatin and etoposide is a feasible treatment for the resectable SCNEC-E, and long-term survival can be achieved in some patients.

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Authors and Affiliations

  1. Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0374, Japan

    Chikatoshi Katada, Akinori Watanabe, Kenji Ishido, Mizutomo Azuma, Takuya Wada & Wasaburo Koizumi

  2. Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0374, Japan

    Shouko Komori, Shogo Kawakami & Hiromichi Ishiyama

  3. Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0374, Japan

    Tsutomu Yoshida

  4. Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0374, Japan

    Kei Hosoda, Keishi Yamashita & Naoki Hiki

  5. Department of Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0374, Japan

    Satoshi Tanabe

Authors
  1. Chikatoshi Katada
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  2. Shouko Komori
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  3. Tsutomu Yoshida
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  4. Shogo Kawakami
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  7. Mizutomo Azuma
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  8. Takuya Wada
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  9. Kei Hosoda
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  10. Keishi Yamashita
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  11. Naoki Hiki
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  12. Satoshi Tanabe
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  14. Wasaburo Koizumi
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Contributions

Conception and design: SK and CK. Collection and assembly of data: all authors. Data analysis and interpretation: SK and CK. Manuscript writing: all authors. Final approval of manuscript: all authors. Financial support: none. Administrative support: SK and CK. Provision of study materials or patients: all authors.

Corresponding author

Correspondence to Chikatoshi Katada.

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Ethical Statement

This is a retrospective study approved by the review board of Kitasato University School of Medicine. Reception number is B15-105.

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There are no financial or other relations that could lead to a conflict of interest.

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Katada, C., Komori, S., Yoshida, T. et al. A retrospective study of definitive chemoradiotherapy in patients with resectable small cell neuroendocrine carcinoma of the esophagus. Esophagus 17, 135–140 (2020). https://doi.org/10.1007/s10388-019-00686-9

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  • DOI: https://doi.org/10.1007/s10388-019-00686-9

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