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Efficacy of on-demand therapy using 20-mg vonoprazan for non-erosive reflux disease

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Abstract

Background

To evaluate the efficacy of on-demand therapy using 20-mg vonoprazan for non-erosive reflux disease.

Methods

On-demand therapy by taking one 20-mg tablet of vonoprazan only when reflux symptoms occurred was performed for 8 weeks by 30 patients (11 men, mean age: 67.8) with non-erosive reflux disease who responded well to maintenance therapy using proton pump inhibitor and answered “very satisfied” or “satisfied” to an overall satisfaction survey (5-grade scale). The degree of overall satisfaction with the treatment, score of symptoms, and fasting gastrin levels before breakfast was examined before and after on-demand therapy. The number of vonoprazan tablets taken and the frequency (regular, temporary, rare) of its administration were also investigated.

Results

All patients completed 8-week on-demand therapy with 20-mg vonoprazan. Comparisons of patient satisfaction levels before and after therapy revealed no significant differences in the number of patients who were very satisfied and satisfied with the therapy. Furthermore, there were no significant differences in score of symptoms or gastrin levels before and after therapy. During 8-week on-demand therapy, patients took 11 tablets (median) (7.0–18.0 tablets: 25–75 percentiles), and 30.0% of patients (n = 9) took vonoprazan on a regular basis (at least 2 tablets a week).

Conclusion

On-demand therapy with 20-mg vonoprazan exerted equivalent effects to continuous PPI maintenance therapy for patients with non-erosive reflux disease.

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Acknowledgements

The authors thank Ms. Satoko Nishimura for administrative assistance.

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Authors and Affiliations

  1. Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan

    Yoshimasa Hoshikawa, Noriyuki Kawami, Shintaro Hoshino, Tomohide Tanabe, Mariko Umezawa, Mitsuru Kaise & Katsuhiko Iwakiri

Authors
  1. Yoshimasa Hoshikawa
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  2. Noriyuki Kawami
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  3. Shintaro Hoshino
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  4. Tomohide Tanabe
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  5. Mariko Umezawa
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  6. Mitsuru Kaise
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  7. Katsuhiko Iwakiri
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Corresponding author

Correspondence to Katsuhiko Iwakiri.

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Ethical statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent or substitute for it was obtained from all patients for being included in the study.

Conflict of interest

Katsuhiko Iwakiri has received lecture fees from Takeda Pharmaceutical Co., Ltd. and Otsuka Pharmaceutical Co., Ltd.. The remaining authors declare that they have no conflicts of interest.

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Hoshikawa, Y., Kawami, N., Hoshino, S. et al. Efficacy of on-demand therapy using 20-mg vonoprazan for non-erosive reflux disease. Esophagus 16, 201–206 (2019). https://doi.org/10.1007/s10388-018-00654-9

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  • DOI: https://doi.org/10.1007/s10388-018-00654-9

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