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A case of large cell neuroendocrine carcinoma of the esophagogastric junction

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Abstract

Neuroendocrine carcinoma of the upper gastrointestinal tract is an uncommon disease that manifests as a highly malignant tumor. We herein report a rare case of large cell neuroendocrine carcinoma of the esophagogastric junction treated with surgery and chemotherapy. A 65-year-old Japanese man was admitted to our hospital for treatment of a tumor of the esophagogastric junction detected by endoscopic examination. Biopsy specimens demonstrated large cell neuroendocrine carcinoma with highly frequent mitoses and positivity for synaptophysin, chromogranin A, and CD56. Computed tomography indicated at least three lymphadenopathies of the left and right cardiac nodes. We performed distal esophagectomy, total gastrectomy and pancreatosplenectomy, and subsequent S-1 adjuvant chemotherapy, but the patient died of liver metastasis 9 months after the surgery. Based on the outcome of the present case, this disease demands establishment of multimodal treatment that includes surgery and chemotherapy.

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Ethical Statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later revision. Informed consent or substitute for it was obtained from the present patient for being included in the study.

Conflict of interest

There are no financial or other relations that could lead to a conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, Gunma Chuo Hospital, 1-7-13 Kouun-cho, Maebashi, Gunma, 371-0025, Japan

    Minoru Fukuchi, Ritsuko Tsukagoshi & Hiroshi Naitoh

  2. Department of Diagnostic Pathology, Gunma Chuo Hospital, Maebashi, 371-0025, Japan

    Shinji Sakurai

  3. Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan

    Hiroyuki Kuwano

Authors
  1. Minoru Fukuchi
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  2. Shinji Sakurai
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  3. Ritsuko Tsukagoshi
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  4. Hiroshi Naitoh
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  5. Hiroyuki Kuwano
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Correspondence to Minoru Fukuchi.

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Fukuchi, M., Sakurai, S., Tsukagoshi, R. et al. A case of large cell neuroendocrine carcinoma of the esophagogastric junction. Esophagus 12, 295–299 (2015). https://doi.org/10.1007/s10388-014-0443-7

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  • DOI: https://doi.org/10.1007/s10388-014-0443-7

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