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Validation of the postnatal growth and retinopathy of prematurity (G-ROP) screening criteria in a Thai cohort

  • Clinical Investigation
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Abstract

Purpose

To validate Postnatal Growth and Retinopathy of Prematurity (G-ROP) criteria for Thai infants.

Study design

A retrospective review of infants receiving ROP screening during 2009–2020.

Methods

Baseline characteristics, clinical progression and final ROP outcomes were collected. G-ROP was applied to infants who met at least one of the following 6 criteria: birth weight (BW) below 1051 g, gestational age (GA) under 28 weeks, weight gain (WG) less than 120 g during postnatal day 10–19, WG less than 180 g during day 20–29, WG less than 170 g during day 30–39 and hydrocephalus.

Results

A total of 684 infants (boys, 53.4%) were included. Median (IQR) BW was 1200 (960–1470) grams and median GA was 30 (28–32) weeks. Prevalence of ROP was 26.6%, with 28 (4.1%) having type 1, 19 (2.8%) type 2 and, 135 (19.7%) having other ROP. Treatment was performed in 26 infants (3.8%). Sensitivity of G-ROP to include type 1, 2 or treatment-requiring ROP cases was 100% with 36.9% specificity, excluding 235 (34.4%) cases of unnecessary screening. To adjust for our setting of initial eye examination at 4 weeks’ postnatal date, the last 2 criteria of G-ROP were replaced by the occurrence of grade 3 or 4 intraventricular hemorrhage (IVH). This modified G-ROP criteria yielded 100% sensitivity, 42.5% specificity and excluded 271 (39.6%) cases of unnecessary screening.

Conclusion

G-ROP criteria can be applied to our hospital setting. Occurrence of IVH grade 3 or 4 was proposed as an alternative in modified G-ROP criteria.

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Acknowledgements

The authors gratefully acknowledge Nutchavadee Vorasan of Siriraj Genomics of the Faculty of Medicine Siriraj Hospital, Mahidol University for her assistance in the use of the REDCap web application. We would like to thank Kevin P Jones for his valuable assistance with English language editing.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand

    Adisak Trinavarat, Saranporn Piampradad, Poonyawee Nunthanid, Dussadee Tatritorn, Thipsukon Amnartpanich, Nutchanok Limkongngam, Thanyaporn Praikanarat, Niracha Arjkongharn & La-ongsri Atchaneeyasakul

  2. Division of Neonatology, Department of Paediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Natthapicha Najmuangchan & Sopapan Ngerncham

  3. Division of Clinical Epidemiology, Department of Health Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Suthipol Udompunthurak

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  1. Adisak Trinavarat
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Corresponding author

Correspondence to La-ongsri Atchaneeyasakul.

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Conflict of interest

A. Trinavarat, None; N. Najmuangchan, None; S. Ngerncham, None; S. Piampradad, None; P. Nunthanid, None; D. Tatritorn, None; T. Amnartpanich, None; N. Limkongngam, None; T. Praikanarat, None; N. Arjkongharn, None; S. Udompunthurak, None; L. Atchaneeyasakul, None.

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Corresponding Author: La-ongsri Atchaneeyasakul

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Trinavarat, A., Najmuangchan, N., Ngerncham, S. et al. Validation of the postnatal growth and retinopathy of prematurity (G-ROP) screening criteria in a Thai cohort. Jpn J Ophthalmol 67, 387–395 (2023). https://doi.org/10.1007/s10384-023-01003-9

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  • DOI: https://doi.org/10.1007/s10384-023-01003-9

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