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Decreased ocular blood flow after photocoagulation therapy in neonatal retinopathy of prematurity

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the relationships between optic nerve head blood flow, expressed as mean blur rate (MBR) measured by laser speckle flowgraphy (LSFG), and photocoagulation therapy in neonates with retinopathy of prematurity (ROP).

Study design

Case series study.

Methods

We studied 5 ROP neonates either during sleep or under sedation both before and after photocoagulation, and evaluated 8 eyes in which the circulation could be measured three times consecutively. Correlations between the MBR-A (mean of all values), MBR-V (vessel mean) and MBR-T (tissue mean) and postmenstrual age were evaluated using Spearman’s rank correlation coefficient. In addition, correlations between the relative MBR (-A, -V, -T) value and number of photocoagulation burns and the NV score were evaluated. Differences between post-treatment MBR in ROP subjects and normal neonates’ MBR were estimated using analysis of covariance (ANCoVA), with adjustment for postmenstrual age.

Results

The relative MBR (-A, -V, -T) values after photocoagulation were 69.6 ± 16.0%, 66.7 ± 17.0% and 74.3 ± 14.6%, respectively. Postmenstrual age was significantly correlated with post-treatment MBR-A (r = 0.83, p = 0.0101), MBR-V (r = 0.85, p = 0.007) and MBR-T (r = 0.76, p = 0.0282). The relative MBR-T value was significantly correlated with the number of photocoagulation burns (r = −0.75, p = 0.033) and NV score (r = −0.72, p = 0.0437). The ANCoVA results showed no significant difference between post-treatment MBR and normal neonates’ MBR.

Conclusions

Photocoagulation improved the dilation of veins and tortuosity of arteries and reduced ocular blood flow in ROP subjects. Since the post-treatment MBR was not different from a normal neonate’s MBR, it is suggested that the pre-treatment MBR was higher in severe ROP cases.

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Acknowledgements

This work was supported by Toho University project Grants (#26-34), a Toho University Nukada scholarship and a Toho University Shibata scholarship. The authors would like to express appreciation for advice on the statistical analysis by Mar S. Oba (Department of Medical Statistics Faculty of Medicine, Toho University).

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Toho University, 6-11-1 Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan

    Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Masahiko Tomita & Yuichi Hori

  2. Department of Neonatology, School of Medicine, Toho University, Tokyo, Japan

    Kotaro Hine, Norio Mizukaki & Hitoshi Yoda

Authors
  1. Tadashi Matsumoto
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  2. Takashi Itokawa
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  3. Tomoaki Shiba
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  4. Masahiko Tomita
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  5. Kotaro Hine
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  6. Norio Mizukaki
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  7. Hitoshi Yoda
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  8. Yuichi Hori
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Corresponding author

Correspondence to Tadashi Matsumoto.

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Conflicts of interest

T. Matsumoto, None; T. Itokawa, None; T. Shiba, None; M. Tomita, None; K. Hine, None; N. Mizukaki, None; H. Yoda, None; Y. Hori, None.

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Matsumoto, T., Itokawa, T., Shiba, T. et al. Decreased ocular blood flow after photocoagulation therapy in neonatal retinopathy of prematurity. Jpn J Ophthalmol 61, 484–493 (2017). https://doi.org/10.1007/s10384-017-0536-7

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  • DOI: https://doi.org/10.1007/s10384-017-0536-7

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