Skip to main content

Advertisement

SpringerLink
Log in

Long-term surgical outcome of conventional trabeculotomy for childhood glaucoma

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the long-term surgical outcomes of conventional trabeculotomy in eyes with childhood glaucoma in a Japanese population.

Methods

In this retrospective observational study, we enrolled Japanese patients with childhood glaucoma who underwent a conventional trabeculotomy at least once before age 3 years from 1986 to 2014 in our hospital.

Results

One hundred seven eyes of 64 patients (24 girls, 40 boys; mean age, 2.8 ± 5.1 months) were included. Sixty-eight (64%) eyes had primary childhood glaucoma (PCG) and 39 (36%) eyes had secondary childhood glaucoma (SCG). The average numbers of surgical operations performed to treat the two glaucoma types that resulted in significantly (p < 0.001) different surgical success rates were 1.4 ± 0.7 and 2.1 ± 0.8. Statistical analysis showed that eyes with PCG, compared with those with SCG, were successfully treated by one trabeculotomy and up to three trabeculotomies (hazard ratios 6.66 and 4.02, respectively). Age, gender, systemic complications, corneal diameter, corneal edema, and preoperative intraocular pressure did not significantly affect the surgical outcomes.

Conclusions

Most eyes with PCG are treatable with a maximum of three trabeculotomies. However, SCG usually is refractory to trabeculotomy, and a more promising surgery must be designed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Khaw PT, Freedman S, Gandolfi S. Management of congenital glaucoma. J Glaucoma. 1999;8:81–5.

    Article  CAS  PubMed  Google Scholar 

  2. Anderson DR. The development of the trabecular meshwork and its abnormality in primary infantile glaucoma. Trans Am Ophthalmol Soc. 1981;79:458–85.

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Ko F, Papadopoulos M, Khaw PT. Primary congenital glaucoma. Prog Brain Res. 2015;221:177–89.

    Article  PubMed  Google Scholar 

  4. Barsoum-Homsy M, Chevrette L. Incidence and prognosis of childhood glaucoma. A study of 63 cases. Ophthalmology. 1986;93:1323–7.

    Article  CAS  PubMed  Google Scholar 

  5. Anderson DR. Trabeculotomy compared to goniotomy for glaucoma in children. Ophthalmology. 1983;90:805–6.

    Article  CAS  PubMed  Google Scholar 

  6. Akimoto M, Tanihara H, Negi A, Nagata M. Surgical results of trabeculotomy ab externo for developmental glaucoma. Arch Ophthalmol. 1994;112:1540–4.

    Article  CAS  PubMed  Google Scholar 

  7. McPherson SD Jr, McFarland D. External trabeculotomy for developmental glaucoma. Ophthalmology. 1980;87:302–5.

    Article  PubMed  Google Scholar 

  8. Luntz MH. Congenital, infantile, and juvenile glaucoma. Ophthalmology. 1979;86:793–802.

    Article  CAS  PubMed  Google Scholar 

  9. Ikeda H, Ishigooka H, Muto T, Tanihara H, Nagata M. Long-term outcome of trabeculotomy for the treatment of developmental glaucoma. Arch Ophthalmol. 2004;122:1122–8.

    Article  PubMed  Google Scholar 

  10. Morales J, Al Shahwan S, Al Odhayb S, Al Jadaan I, Edward DP. Current surgical options for the management of pediatric glaucoma. J Ophthalmol. 2013;2013:763735.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ghate D, Wang X. Surgical interventions for primary congenital glaucoma. Cochrane Database Syst Rev. 2015;1:CD008213.

    PubMed  PubMed Central  Google Scholar 

  12. Fung DS, Roensch MA, Kooner KS, Cavanagh HD, Whitson JT. Epidemiology and characteristics of childhood glaucoma: results from the Dallas Glaucoma Registry. Clin Ophthalmol. 2013;7:1739–46.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Inaba Z. Long-term results of trabeculectomy in the Japanese: an analysis by life-table method. Jpn J Ophthalmol. 1982;26:361–73.

    CAS  PubMed  Google Scholar 

  14. Papadopoulos M, Cable N, Rahi J, Khaw PT. Investigators BIGES. The British Infantile and Childhood Glaucoma (BIG) Eye Study. Invest Ophthalmol Vis Sci. 2007;48:4100–6.

    Article  PubMed  Google Scholar 

  15. Larsen JS. The sagittal growth of the eye. IV. Ultrasonic measurement of the axial length of the eye from birth to puberty. Acta Ophthalmol (Copenh). 1971;49:873–86.

    Article  CAS  Google Scholar 

  16. Alsheikheh A, Klink J, Klink T, Steffen H, Grehn F. Long-term results of surgery in childhood glaucoma. Graefes Arch Clin Exp Ophthalmol. 2007;245:195–203.

    Article  PubMed  Google Scholar 

  17. Alanazi FF, Song JC, Mousa A, Morales J, Al Shahwan S, Alodhayb S, et al. Primary and secondary congenital glaucoma: baseline features from a registry at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Am J Ophthalmol. 2013;155:882–9.

    Article  PubMed  Google Scholar 

  18. Mandal AK, Matalia JH, Nutheti R, Krishnaiah S. Combined trabeculotomy and trabeculectomy in advanced primary developmental glaucoma with corneal diameter of 14 mm or more. Eye (Lond). 2006;20:135–43.

    Article  CAS  PubMed  Google Scholar 

  19. Dannheim R, Haas H. Visual acuity and intraocular pressure after surgery in congenital glaucoma. Klin Monbl Augenheilkd. 1980;177:296–303 (in German).

    Article  CAS  PubMed  Google Scholar 

  20. Waheed S, Ritterband DC, Greenfield DS, Liebmann JM, Sidoti PA, Ritch R. Bleb-related ocular infection in children after trabeculectomy with mitomycin C. Ophthalmology. 1997;104:2117–20.

    Article  CAS  PubMed  Google Scholar 

  21. Greenfield DS, Suner IJ, Miller MP, Kangas TA, Palmberg PF, Flynn HW Jr. Endophthalmitis after filtering surgery with mitomycin. Arch Ophthalmol. 1996;114:943–9.

    Article  CAS  PubMed  Google Scholar 

  22. O’Malley Schotthoefer E, Yanovitch TL, Freedman SF. Aqueous drainage device surgery in refractory pediatric glaucomas: I. Long-term outcomes. J AAPOS. 2008;12:33–9.

    Article  PubMed  Google Scholar 

  23. Ou Y, Yu F, Law SK, Coleman AL, Caprioli J. Outcomes of Ahmed glaucoma valve implantation in children with primary congenital glaucoma. Arch Ophthalmol. 2009;127:1436–41.

    Article  PubMed  Google Scholar 

  24. Morad Y, Donaldson CE, Kim YM, Abdolell M, Levin AV. The Ahmed drainage implant in the treatment of pediatric glaucoma. Am J Ophthalmol. 2003;135:821–9.

    Article  PubMed  Google Scholar 

  25. Munuera JM, García-Layana A, Maldonado MJ, Aliseda D, Moreno-Montañés J. OPtical coherence tomography in successful surgery of vitreomacular traction syndrome. Arch Ophthalmol. 1998;116:1388–9.

    CAS  PubMed  Google Scholar 

  26. van Overdam KA, de Faber JT, Lemij HG, de Waard PW. Baerveldt glaucoma implant in paediatric patients. Br J Ophthalmol. 2006;90:328–32.

    Article  PubMed  PubMed Central  Google Scholar 

  27. McPherson SD Jr. Results of external trabeculotomy. Trans Am Ophthalmol Soc. 1973;71:163–7 (discussion 68-70).

    PubMed  PubMed Central  Google Scholar 

  28. Quigley HA. Childhood glaucoma: results with trabeculotomy and study of reversible cupping. Ophthalmology. 1982;89:219–26.

    Article  CAS  PubMed  Google Scholar 

  29. Kargi SH, Koc F, Biglan AW, Davis JS. Visual acuity in children with glaucoma. Ophthalmology. 2006;113:229–38.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank the patients for participation in this study. This work was supported by grants from the Ministry of Health, Labour, and Welfare (H24-Nanchi-Ippan-031) and the National Centre for Child Health and Development 25-7.

Author information

Authors and Affiliations

  1. Department of Ophthalmology and Laboratory for Visual Science, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan

    Hiroko Ozawa, Mio Yamane, Tomoyo Yoshida-Uemura, Satoshi Katagiri, Tadashi Yokoi, Sachiko Nishina & Noriyuki Azuma

  2. Center for Clinical Research and Development, National Center for Child Health and Development, Tokyo, Japan

    Eisuke Inoue

  3. Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan

    Satoshi Katagiri

Authors
  1. Hiroko Ozawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mio Yamane
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eisuke Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tomoyo Yoshida-Uemura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Satoshi Katagiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tadashi Yokoi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sachiko Nishina
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Noriyuki Azuma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Noriyuki Azuma.

Ethics declarations

Conflicts of interest

H. Ozawa, None; M. Yamane, None; E. Inoue, Lecture fees (Merck Serono); T. Y. -Uemura, None; S. Katagiri, None; T. Yokoi, None; S. Nishina, None; N. Azuma, None.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 76 kb)

Supplementary material 2 (TIFF 2591 kb)

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ozawa, H., Yamane, M., Inoue, E. et al. Long-term surgical outcome of conventional trabeculotomy for childhood glaucoma. Jpn J Ophthalmol 61, 237–244 (2017). https://doi.org/10.1007/s10384-017-0506-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-017-0506-0

Keywords

Search

Navigation