Skip to main content

Advertisement

SpringerLink
Log in

Changes in visual field defects during 10-year follow-up for indocyanine green-assisted macular hole surgery

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To determine whether the visual field defects detected within 3 months of indocyanine green (ICG)-assisted inner-limiting membrane (ILM) peeling continue to worsen over longer periods.

Methods

This was a retrospective observational case series. Four eyes with visual field defects that developed within 3 years of ICG-assisted ILM peeling for a macular hole (MH) were examined yearly for 10 years. The main outcome measures were the degree of mean deviation (MD) determined by Humphrey perimetry with the 30-2 SITA-Fast program and the best-corrected visual acuity (BCVA).

Results

Four patients were examined yearly for more than 10 years, with a mean duration of follow-up of 139.5 months (11.6 years) and a range of follow-up of 137–156 months (11.4–13 years). The mean (±standard deviation) preoperative MD value was −4.99 ± 3.26 dB, and the mean postoperative MD values were −12.9 ± 1.29 dB after 1 year, −14.1 ± 0.75 dB after 3 years, and −12.73 ± 2.65 dB after 10 years. The mean preoperative BCVA was 0.65 ± 0.26 logarithm of the minimal angle of resolution (logMAR) units, and the postoperative BCVA was 0.21 ± 0.07 logMAR units at 1 year, 0.28 ± 0.21 logMAR units at 3 years, and 0.14 ± 0.06 dB logMAR units at 10 years.

Conclusions

The visual field defects detected soon after ICG-assisted ILM peeling continued to worsen for 3 years, but not thereafter.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Eshita T, Ishida S, Shinoda K, Kitamura S, Inoue M, Oguchi Y, et al. Indocyanine green can distinguish posterior vitreous cortex from internal limiting membrane during vitrectomy with removal of epiretinal membrane. Retina. 2002;22:104–6.

    Article  PubMed  Google Scholar 

  2. Gandorfer A, Messmer EM, Ulbig MW, Kampik A. Indocyanine green selectively stains the internal limiting membrane. Am J Ophthalmol. 2001;131:387–8.

    Article  CAS  PubMed  Google Scholar 

  3. Horio N, Horiguchi M. Effect on visual outcome after macular hole surgery when staining the internal limiting membrane with indocyanine green dye. Arch Ophthalmol. 2004;122:992–6.

    Article  PubMed  Google Scholar 

  4. Rodrigues EB, Meyer CH, Kroll P. Chromovitrectomy: a new field in vitreoretinal surgery. Graefes Arch Clin Exp Ophthalmol. 2005;243:291–3.

    Article  PubMed  Google Scholar 

  5. Schmidt JC, Meyer CH, Rodrigues EB, Hoerle S, Kroll P. Staining of internal limiting membrane in vitreomacular surgery: a simplified technique. Retina. 2003;23:263–4 (author reply 264).

    Article  CAS  PubMed  Google Scholar 

  6. Mochizuki N, Yamamoto T, Enaida H, Ishibashi T, Yamashita H. Long-term outcomes of 3 surgical adjuvants used for internal limiting membrane peeling in idiopathic macular hole surgery. Jpn J Ophthalmol. 2014;58:455–61.

    Article  CAS  PubMed  Google Scholar 

  7. Haritoglou C, Gandorfer A, Gass CA, Kampik A. Indocyanine green staining and removal of internal limiting membrane in macular hole surgery: histology and outcome. Am J Ophthalmol. 2002;133:587–8 (author reply 588).

    Article  PubMed  Google Scholar 

  8. Kanda S, Uemura A, Yamashita T, Kita H, Yamakiri K, Sakamoto T. Visual field defects after intravitreous administration of indocyanine green in macular hole surgery. Arch Ophthalmol. 2004;122:1447–51.

    Article  CAS  PubMed  Google Scholar 

  9. Rodrigues EB, Meyer CH, Mennel S, Farah ME. Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Retina. 2007;27:958–70.

    Article  PubMed  Google Scholar 

  10. Tsuiki E, Fujikawa A, Miyamura N, Yamada K, Mishima K, Kitaoka T. Visual field defects after macular hole surgery with indocyanine green-assisted internal limiting membrane peeling. Am J Ophthalmol. 2007;143:704–5.

    Article  PubMed  Google Scholar 

  11. Uemura A, Kanda S, Sakamoto Y, Kita H. Visual field defects after uneventful vitrectomy for epiretinal membrane with indocyanine green-assisted internal limiting membrane peeling. Am J Ophthalmol. 2003;136:252–7.

    Article  PubMed  Google Scholar 

  12. Enaida H, Sakamoto T, Hisatomi T, Goto Y, Ishibashi T. Morphological and functional damage of the retina caused by intravitreous indocyanine green in rat eyes. Graefes Arch Clin Exp Ophthalmol. 2002;240:209–13.

    Article  PubMed  Google Scholar 

  13. Maia M, Kellner L, de Juan E Jr, Smith R, Farah ME, Margalit E, et al. Effects of indocyanine green injection on the retinal surface and into the subretinal space in rabbits. Retina. 2004;24:80–91.

    Article  PubMed  Google Scholar 

  14. Machida S, Fujiwara T, Gotoh T, Hasegawa Y, Gotoh A, Tazawa Y. Observation of the ocular fundus by an infrared-sensitive video camera after vitreoretinal surgery assisted by indocyanine green. Retina. 2003;23:183–91.

    Article  PubMed  Google Scholar 

  15. Tadayoni R, Paques M, Girmens JF, Massin P, Gaudric A. Persistence of fundus fluorescence after use of indocyanine green for macular surgery. Ophthalmology. 2003;110:604–8.

    Article  PubMed  Google Scholar 

  16. von Jagow B, Hoing A, Gandorfer A, Rudolph G, Kohnen T, Kampik A, et al. Functional outcome of indocyanine green-assisted macular surgery: 7-year follow-up. Retina. 2009;29:1249–56.

    Article  Google Scholar 

  17. Yamashita T, Uemura A, Kita H, Nakao K, Sakamoto T. Long-term outcomes of visual field defects after indocyanine green-assisted macular hole surgery. Retina. 2008;28:1228–33.

    Article  PubMed  Google Scholar 

  18. Yamashita T, Uemura A, Kita H, Sakamoto T. Analysis of the retinal nerve fiber layer after indocyanine green-assisted vitrectomy for idiopathic macular holes. Ophthalmology. 2006;113:280–4.

    Article  PubMed  Google Scholar 

  19. The AGIS Investigators. The advanced glaucoma intervention study(AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000;130:429–40.

    Article  Google Scholar 

  20. Armaly MF, Krueger DE, Maunder L, Becker B, Hetherington J Jr, Kolker AE, et al. Biostatistical analysis of the collaborative glaucoma study. I. Summary report of the risk factors for glaucomatous visual-field defects. Arch Ophthalmol. 1980;98:2163–71.

    Article  CAS  PubMed  Google Scholar 

  21. Lochhead J, Jones E, Chui D, Lake S, Karia N, Patel CK, et al. Outcome of ICG-assisted ILM peel in macular hole surgery. Eye (Lond). 2004;18:804–8.

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This study was in part sponsored by a grant from the Research Committee on Chorioretinal Degeneration and Optic Atrophy, Ministry of Health, Labor, and Welfare of Japan and by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Masanori Nakazawa, Hiroto Terasaki, Takehiro Yamashita & Taiji Sakamoto

  2. Department of Ophthalmology, Kagoshima City Hospital, Kagoshima, Japan

    Akinori Uemura

Authors
  1. Masanori Nakazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroto Terasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takehiro Yamashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Akinori Uemura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Taiji Sakamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Taiji Sakamoto.

Ethics declarations

Conflicts of interest

M. Nakazawa, None; H. Terasaki, None; T. Yamashita, None; A. Uemura, None; T. Sakamoto, None.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nakazawa, M., Terasaki, H., Yamashita, T. et al. Changes in visual field defects during 10-year follow-up for indocyanine green-assisted macular hole surgery. Jpn J Ophthalmol 60, 383–387 (2016). https://doi.org/10.1007/s10384-016-0453-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-016-0453-1

Keywords

Search

Navigation