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Radiation-induced lichen sclerosus of the vulva

First report in the medical literature

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Summary

A 67-year-old woman presented with a firm plaque in the perineal region, 16 months after diagnosis of a high-grade basaloid squamous cell carcinoma of the vagina and treatment by external beam radiation therapy and vaginal cuff brachytherapy. The differential diagnosis included radiation-induced morphea, radiation dermatitis, or, possibly, radiation-induced lichen sclerosus. Biopsy findings, including special staining, confirmed the diagnosis of radiation-induced lichen sclerosus. To our knowledge, this is the first report of radiation-induced lichen sclerosus of the vulvar region.

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Author information

Authors and Affiliations

  1. School of Medicine, University of Virginia Health System, Charlottesville, VA, USA

    Lisa R. Edwards

  2. Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA

    Emily D. Privette,  James W. Patterson MD &  Barbara B. Wilson

  3. Department of Pathology, University of Virginia Health System, 1215 Lee Street, Box 800214, 22908, Charlottesville, VA, USA

    James W. Patterson MD

  4. Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), General Skobelev blvd. 79, 1606, Sofia, Bulgaria

    Georgi Tchernev

  5. “Onkoderma”-Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26 blvd., Sofia, Bulgaria

    Anastasiya Atanasova Chokoeva

  6. Department of Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria

    Anastasiya Atanasova Chokoeva

  7. Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany

    Uwe Wollina

  8. Dermatology, University of Rome “G.Marconi”, Rome, Italy

    Torello Lotti MD, MD (Hon)

Authors
  1. Lisa R. Edwards
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  2. Emily D. Privette
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  3. James W. Patterson MD
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  4. Georgi Tchernev
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  5. Anastasiya Atanasova Chokoeva
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  6. Uwe Wollina
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  7. Torello Lotti MD, MD (Hon)
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  8. Barbara B. Wilson
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Corresponding author

Correspondence to Georgi Tchernev.

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Conflict of interest

L.R. Edwards, E.D. Privette, J.W. Patterson, G. Tchernev, A.A. Chokoeva, U. Wollina, T. Lotti, and B.B. Wilson declare that they have no competing interests.

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Edwards, L.R., Privette, E.D., Patterson, J.W. et al. Radiation-induced lichen sclerosus of the vulva. Wien Med Wochenschr 167, 74–77 (2017). https://doi.org/10.1007/s10354-016-0525-3

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  • DOI: https://doi.org/10.1007/s10354-016-0525-3

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