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Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances

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Abstract

Dissolution-DNP is a method to boost liquid-state NMR sensitivity by several orders of magnitude. The technique consists in hyperpolarizing samples by solid-state dynamic nuclear polarization at low temperature and moderate magnetic field, followed by an instantaneous melting and dilution of the sample happening inside the polarizer. Although the technique is well established and the outstanding signal enhancement paved the way towards many applications precluded to conventional NMR, the race to develop new methods allowing higher throughput, faster and higher polarization, and longer exploitation of the signal is still vivid. In this work, we review the most recent advances on dissolution-DNP methods trying to overcome the original technique’s shortcomings. The review describes some of the new approaches in the field, first, in terms of sample formulation and properties, and second, in terms of instrumentation.

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Acknowledgements

This work was supported by the Danish National Research Foundation (DNRF124), the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 713683 (COFUNDfellowsDTU), and the Swiss National Fund under the SPARK Grant Agreement No. CRSK-2_190547.

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  1. Department of Health Technology, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Building 349, 2800, Kgs Lyngby, Denmark

    Arthur C. Pinon, Andrea Capozzi & Jan Henrik Ardenkjær-Larsen

  2. Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Route Cantonale, 1015, Lausanne, Switzerland

    Andrea Capozzi

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  1. Arthur C. Pinon
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  2. Andrea Capozzi
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JA review article conception; ACP drafting of manuscript; AC and JA critical revision.

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Correspondence to Jan Henrik Ardenkjær-Larsen.

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Conflict of interest

JA is an employee of GE Healthcare and the owner of the company Polarize. We have no further potential conflicts of interest. This review does not involve any human participants or animal research.

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Pinon, A.C., Capozzi, A. & Ardenkjær-Larsen, J.H. Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances. Magn Reson Mater Phy 34, 5–23 (2021). https://doi.org/10.1007/s10334-020-00894-w

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