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Clinical features of multiple system atrophy with or without rapid eye movement behavior disorder: a cross-sectional study in southwest China

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Abstract

Objective

The aim of this study was to investigate the prevalence of rapid eye movement behavior disorder (RBD) in Chinese patients with multiple system atrophy (MSA) and to compare motor and non-motor symptoms and sleep disturbance of MSA patients with and without RBD.

Methods

A total of 55 patients who were consecutively admitted to West China Hospital of Sichuan University from 2016 to 2019 and subsequently diagnosed with probable MSA were enrolled in this cross-sectional study. The diagnosis of RBD was based on the results of video polysomnography (PSG) and a history of abnormal sleep-related behaviors. The patients were divided into two groups: those with RBD and those without. These two groups were then compared in terms of severity of motor symptoms (Unified Multiple System Arophy Rating Scale) and non-motor symptoms (Non-Motor Symptoms Scale, Mini-Mental State Examination score, Epworth Sleepiness Scale, Fatigue Severity Scale, Pittsburgh Sleep Quality Index, REM Sleep Behavior Disorder Screening Questionnaire, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale) and sleep parameters as recorded on PSG.

Results

Of the 55 patients (35 males), 18 (33%, 13 males) were diagnosed with RBD. Patients with or without RBD did not differ in demographic characteristics, clinical features, or sleep parameters based on PSG.

Conclusion

There was no difference in motor and non-motor symptoms between MSA patients with or without RBD, indicating that the presence of RBD may not be significantly associated with the severity of motor or non-motor dysfunction in MSA.

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Acknowledgements

The authors would like to thank the study participants and the staff of the Sleep Medicine Center of West China Hospital.

Funding

This work was supported by the Basic Conditions Platform Construction Project of Sichuan Science and Technology Department [2019JDPT0015].

Author information

Author notes

  1. Hui Wang and Ran An contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

    Hui Wang, Ran An, Yalan Chen, Xin Mu, Baiyuan Yang, Quanzhen Zhao, Hongyan Huang, Pingping Ning, Qiuyan Shen, Dan Xie, Haitao Lu & Yanming Xu

  2. Department of Rehabilitation, West China Hospital, Sichuan University, Chengdu, China

    Ran An

  3. Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, China

    Junying Zhou

  4. Department of Neurology, First People’s Hospital of Chengdu, Chengdu, China

    Xin Mu

  5. Department of Neurology, Seventh People’s Hospital of Chengdu, Chengdu, China

    Baiyuan Yang

Authors
  1. Hui Wang
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  2. Ran An
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  3. Yalan Chen
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  4. Xin Mu
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  5. Baiyuan Yang
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  6. Quanzhen Zhao
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  7. Hongyan Huang
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  8. Pingping Ning
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  9. Qiuyan Shen
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  10. Dan Xie
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  11. Haitao Lu
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  12. Junying Zhou
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  13. Yanming Xu
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Contributions

HW and RA contributed to the acquisition of the data, statistical analysis, and interpretation of the data, and drafted the manuscript. JZ and YX contributed to the study concept and design, acquisition of the data, statistical analysis, and critical revision of the manuscript for important intellectual content. YC, XM, BY, QZ, HYH, PN, QS, DX, and HL contributed to the acquisition of the data and clinical assessment.

Corresponding authors

Correspondence to Junying Zhou or Yanming Xu.

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All authors state that they have no conflicts of interest to declare.

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Cite this article

Wang, H., An, R., Chen, Y. et al. Clinical features of multiple system atrophy with or without rapid eye movement behavior disorder: a cross-sectional study in southwest China. Clin Auton Res 30, 239–245 (2020). https://doi.org/10.1007/s10286-019-00651-7

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  • DOI: https://doi.org/10.1007/s10286-019-00651-7

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