Skip to main content

Advertisement

SpringerLink
Log in

Cardiovascular disease risks in adult Native and Mexican Americans with a history of alcohol use disorders: association with cardiovascular autonomic control

  • Research Article
  • Published:
Clinical Autonomic Research Aims and scope Submit manuscript

Abstract

Hypertension and obesity are serious health problems that have been associated with an increased risk of cardiovascular disease (CVD). We recently showed a relationship between hypertension, obesity and cardiovagal control in a sample of Native and Mexican Americans at high risk of alcohol use disorders (AUD). While studies have shown that Native and Mexican Americans exhibit high rates of AUD, the consequences of AUD on CVD risk factors and their relationship with cardiovascular autonomic control is not well understood in these ethnic groups. This study investigated whether an association could be demonstrated between cardiovascular autonomic control and several CVD risk factors in Native and Mexican American men and women (n = 228) who are literate in English and are residing legally in San Diego County. Participants with lifetime history of AUD showed higher rates of systolic and diastolic hypertension and obesity than participants without lifetime AUD. Lifetime AUD was significantly associated with reduced HR response to deep breathing (HRDB) measure of cardiovagal control, higher current drinking quantity, and obesity. Reduced HRDB was also associated with increased systolic pre-hypertension or hypertension (pre-/hypertension) and with higher diastolic blood pressure in a linear regression model that included several diagnostic and demographic variables. HRDB and time- and frequency-domain measures of cardiovagal control were significantly reduced in participants with diastolic pre-/hypertension. These data suggest that lower cardiovagal control may play a role in the prevalence of systolic and diastolic pre-/hypertension in a community sample with a history of alcohol and substance use disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Substance Abuse and Mental Health Services Administration. Results from the 2008 National Survey on Drug Use and Health: National Findings. (Office of Applied Studies, NSDUH Series H-36, HHS Publication No. SMA 09-4434), Rockville, MD. 2009

  2. Briasoulis A, Agarwal V, Messerli FH (2012) Alcohol consumption and the risk of hypertension in men and women: a systematic review and meta-analysis. J Clin Hypertens 14:792–798

    Article  Google Scholar 

  3. Criado JR, Gilder DA, Kalafut MA, Ehlers CL (2013) Obesity in American Indian and Mexican American men and women: associations with blood pressure and cardiovascular autonomic control. Cardiovasc Psychiatry Neurol. doi:10.1155/2013/680687

    PubMed  PubMed Central  Google Scholar 

  4. Ehlers CL, Gilder DA, Wall TL, Phillips E, Feiler H, Wilhelmsen KC (2004) Genomic screen for loci associated with alcohol dependence in Mission Indians. Am J Med Genet B Neuropsychiatr Genet 129B:110–115

    Article  PubMed  Google Scholar 

  5. Ehlers CL, Wilhelmsen KC (2007) Genomic screen for substance dependence and body mass index in southwest California Indians. Genes Brain Behav 6:184–191

    Article  PubMed  Google Scholar 

  6. Hasin DS, Stinson FS, Ogburn E, Grant BF (2007) Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiology Survey on Alcohol and Related Conditions. Arch Gen Psychiatry 64:830–842

    Article  PubMed  Google Scholar 

  7. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O’Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y (2008) Heart disease and stroke statistics—2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117:e25–e146

    Article  PubMed  Google Scholar 

  8. Trimble B, Morgenstern LB (2008) Stroke in minorities. Neurol Clin 26:1177–1190

    Article  PubMed  PubMed Central  Google Scholar 

  9. Smith MA, Risser JM, Lisabeth LD, Moyé LA, Morgenstern LB (2003) Access to care, acculturation, and risk factors for stroke in Mexican Americans: the brain attack surveillance in corpus christi (BASIC) project. Stroke 34:2671–2675

    Article  PubMed  Google Scholar 

  10. Caetano R, Ramisetty-Mikler S, Rodriguez LA (2009) The Hispanic Americans Baseline Alcohol Survey (HABLAS): the association between birthplace, acculturation and alcohol abuse and dependence across Hispanic national groups. Drug Alcohol Depend 99:215–221

    Article  PubMed  PubMed Central  Google Scholar 

  11. Mancia G, Grassi G (2014) The autonomic nervous system and hypertension. Circ Res 114:1804–1814

    Article  CAS  PubMed  Google Scholar 

  12. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 93:1043–1065

    Article  Google Scholar 

  13. Freeman RL (2008) Noninvasive evaluation of heart rate: time and frequency domains. In: Low PA, Benarroch EE (eds) Clinical autonomic disorders, 3rd edn. Lippincott Williams & Wilkins, Baltimore, pp 185–197

    Google Scholar 

  14. Thayer JF, Yamamoto SS, Brosschot JF (2010) The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int J Cardiol 141:122–131

    Article  PubMed  Google Scholar 

  15. Karpyak VM, Romanowicz M, Schmidt JE, Lewis KA, Bostwick JM (2014) Characteristics of heart rate variability in alcohol-dependent subjects and nondependent chronic alcohol users. Drug Alcohol Depend 38:9–26

    Google Scholar 

  16. Quintana DS, McGregor IS, Guastella AJ, Malhi GS, Kemp AH (2013) A meta-analysis on the impact of alcohol dependence on short-term resting-state heart rate variability: implications for cardiovascular risk. Alcohol Clin Exp Res 37:E23–E29

    Article  PubMed  Google Scholar 

  17. Garland EL, Franken IH, Howard MO (2012) Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment. Psychopharmacology 222:17–26

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Quintana DS, Guastella AJ, McGregor IS, Hickie IB, Kemp AH (2013) Heart rate variability predicts alcohol craving in alcohol dependent outpatients: further evidence for HRV as a psychophysiological marker for self-regulation. Drug Alcohol Depend 132:395–398

    Article  PubMed  Google Scholar 

  19. Bär K-J, Boettger MK, Boettger S, Groeteluschen M, Neubauer R, Jochum T, Baier V, Sauer H, Voss A (2006) Reduced baroreflex sensitivity in acute alcohol withdrawal syndrome and in abstained alcoholics. Drug Alcohol Depend 85:66–74

    Article  PubMed  Google Scholar 

  20. Palatini P, Julius S (2009) The role of cardiac autonomic function in hypertension and cardiovascular disease. Curr Hypertens Rep 11:199–205

    Article  PubMed  Google Scholar 

  21. Boschloo L, Vogelzangs N, Licht CM, Vreeburg SA, Smit JH, van den Brink W, Veltman DJ, de Geus EJC, Beekman AT, Penninx BW (2011) Heavy alcohol use, rather than alcohol dependence, is associated with dysregulation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. Drug Alcohol Depend 116:170–176

    Article  CAS  PubMed  Google Scholar 

  22. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington

    Google Scholar 

  23. Allen JJB, Chambers AS, Towers DN (2007) The many metrics of cardiac chronotopy: a pragmatic primer and a brief comparison of metrics. Biol Psychol 74:243–262

    Article  PubMed  Google Scholar 

  24. Low PA, Sletten DM (2008) Laboratory evaluation of autonomic failure. In: Low PA, Benarroch EE (eds) Clinical Autonomic Disorders, 3rd edn. Lippincott Williams & Wilkins, Baltimore, pp 130–163

    Google Scholar 

  25. Shields RW Jr (2009) Heart rate variability with deep breathing as a clinical test of cardiovagal function. Clevel Clin J Med 76:S37–S40

    Article  Google Scholar 

  26. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (1993) The 1992 report of the joint national committee on detection, evaluation, and treatment of high blood pressure. Arch Intern Med 153:154–183

    Article  Google Scholar 

  27. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289:2560–2572

    Article  CAS  PubMed  Google Scholar 

  28. Faul F, Erdfelder E, Buchner A, Lang AG (2009) Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 41:1149–1160

    Article  PubMed  Google Scholar 

  29. Pagani M, Lombardi F, Guzzetti S, Sandrone G, Rimoldi O, Malfatto G, Cerutti S, Malliani A (1984) Power spectral density of heart rate variability as an index of sympatho-vagal interaction in normal and hypertensive subjects. J Hypertens Suppl 2:S383–S385

    CAS  PubMed  Google Scholar 

  30. Goldstein DS, Bentho O, Park M-Y, Sharabi Y (2011) LF power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes. Exp Physiol 96:1255–1261

    Article  PubMed  PubMed Central  Google Scholar 

  31. Heathers JAJ (2014) Everything Hertz: methodological issues in short-term frequency-domain HRV. Front Physiol 5:177. doi:10.3389/fphys.2014.00177

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

Funding for this study was provided by grants from the National Institutes of Health (NIH); from the National Institute on Alcoholism and Alcohol Abuse (NIAAA) and the National Center on Minority Health and Health Disparities (NCMHD) 5R37AA010201-17, (NIAAA) AA006420-29 and from the Hearst Endowment (MAK). NIAAA, NCMHD, and the Hearst Endowment had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. The authors thank Derek Wills, Greta Berg, Evelyn Phillips, Philip Lau, Susan Lopez and Linda Corey for assistance in data collection and analyses, and Shirley Sanchez for assistance in editing the manuscript.

Author information

Authors and Affiliations

  1. Scripps Autonomic Neuro Lab, Division of Neurology, Scripps Clinic, 10666 North Torrey Pines Rd., MS-313, La Jolla, CA, 92037, USA

    José R. Criado & Mary A. Kalafut

  2. Division of Neurology, Stroke Center, Scripps Clinic, Green Hospital, La Jolla, CA, 92037, USA

    Mary A. Kalafut

  3. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA

    José R. Criado, David A. Gilder & Cindy L. Ehlers

Authors
  1. José R. Criado
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A. Gilder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mary A. Kalafut
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cindy L. Ehlers
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to José R. Criado.

Ethics declarations

Conflict of interest

The authors declare that they have no conflicts of interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Criado, J.R., Gilder, D.A., Kalafut, M.A. et al. Cardiovascular disease risks in adult Native and Mexican Americans with a history of alcohol use disorders: association with cardiovascular autonomic control. Clin Auton Res 26, 87–95 (2016). https://doi.org/10.1007/s10286-015-0333-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10286-015-0333-7

Keywords

Search

Navigation