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Dynamic Contrast-Enhanced MRI in the Study of Brain Tumors. Comparison Between the Extended Tofts-Kety Model and a Phenomenological Universalities (PUN) Algorithm

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Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a well-established technique for studying blood–brain barrier (BBB) permeability that allows measurements to be made for a wide range of brain pathologies, including multiple sclerosis and brain tumors (BT). This latter application is particularly interesting, because high-grade gliomas are characterized by increased microvascular permeability and a loss of BBB function due to the structural abnormalities of the endothelial layer. In this study, we compared the extended Tofts-Kety (ETK) model and an extended derivate class from phenomenological universalities called EU1 in 30 adult patients with different BT grades. A total of 75 regions of interest were manually drawn on the MRI and subsequently analyzed using the ETK and EU1 algorithms. Significant linear correlations were found among the parameters obtained by these two algorithms. The means of R 2 obtained using ETK and EU1 models for high-grade tumors were 0.81 and 0.91, while those for low-grade tumors were 0.82 and 0.85, respectively; therefore, these two models are equivalent. In conclusion, we can confirm that the application of the EU1 model to the DCE-MRI experimental data might be a useful alternative to pharmacokinetic models in the study of BT, because the analytic results can be generated more quickly and easily than with the ETK model.

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Acknowledgment

We thank Dr. Simone Mazzetti (Institute for Cancer Research and Treatment, Candiolo (TO), Italy) for his valuable help with the EU1 algorithm.

Conflicts of Interest

The authors declare that they have no conflicts of interest concerning this article.

Author information

Authors and Affiliations

  1. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Via De Toni 5, 16132, Genoa, Italy

    Maurizio Bergamino & Gianluigi Mancardi

  2. Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Via De Toni 5, 16132, Genoa, Italy

    Maurizio Bergamino, Gianluigi Mancardi & Luca Roccatagliata

  3. Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, Largo Rosanna Benzi 10, 16132, Genoa, Italy

    Laura Barletta, Lucio Castellan & Luca Roccatagliata

  4. Department of Health Sciences, University of Genoa, Largo Rosanna Benzi 10, 16132, Genoa, Italy

    Luca Roccatagliata

Authors
  1. Maurizio Bergamino
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  2. Laura Barletta
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  3. Lucio Castellan
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  4. Gianluigi Mancardi
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  5. Luca Roccatagliata
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Correspondence to Maurizio Bergamino.

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Bergamino, M., Barletta, L., Castellan, L. et al. Dynamic Contrast-Enhanced MRI in the Study of Brain Tumors. Comparison Between the Extended Tofts-Kety Model and a Phenomenological Universalities (PUN) Algorithm. J Digit Imaging 28, 748–754 (2015). https://doi.org/10.1007/s10278-015-9788-2

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  • DOI: https://doi.org/10.1007/s10278-015-9788-2

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