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Peri-implant treatment reduces the salivary levels of Colony stimulator factor-1 and S100A8/A9

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Abstract

This study evaluated the impact of peri-implant treatment in the salivary levels of Colony stimulator factor -1 (CSF-1), S100A8/A9 and S100A12 in patients having mucositis or peri-implantitis. As a secondary aim, we analysed the correlation between the salivary and peri-implant crevicular fluid (PICF) levels. Forty-seven patient, 27 having mucositis (mean age 63.11 ± 7.78) and 20 having peri-implantitis (61.25 ± 7.01) participated in the study. Clinical parameters, probing pocket depth, clinical attachment level, % of plaque and bleeding on probing were evaluated. Unstimulated whole saliva was collected from all patients, while PICF was collected only from a patient’s subgroup (n = 20). Samples were collected before and 3 months after peri-implant treatment. Enzyme-linked immunosorbent assays determined levels of CSF-1, S100A8/A9 and S100A12. Clinical parameters improved and salivary levels of CSF-1 and S100A8/A9, but not S100A12, reduced significantly after treatment in both groups. No significant correlation was found in the salivary and PICF levels of the same molecule. In conclusion, the treatment of peri-implant disease significantly improved the clinical parameters and reduced the salivary levels of CSF-1 and S100A8/A9. The salivary expressions of CSF-1, S100A8/A9 and S100A12 did not correlate with their own expression in PICF.

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Funding

The work was supported by the New Research Grant of Griffith University, Queensland, Australia.

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Authors and Affiliations

  1. School of Dentistry and Oral Health and Menzies Health Institute Queensland, Griffith University Queensland, Gold Coast campus Parklands Drive, Southport, QLD, 4222, Australia

    João Martins de Mello-Neto, Deepak Ipe & Carlos Marcelo Figueredo

  2. Department of Prosthodontics, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil

    Mayla Kezy Silva Teixeira, Glaucia Schuindt Teixeira, Eduardo José Veras Lourenço & Daniel Moraes Telles

  3. Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden

    Ronaldo Lira-Junior & Elisabeth Almer Boström

  4. Oral Medicine and Oral Oncology, Griffith and Menzies Health Institute Queensland, Southport, QLD, Australia

    Raj G. Nair

  5. Haematology and Oncology, Gold Coast Hospital, Queensland Health, Brisbane, Australia

    Raj G. Nair

Authors
  1. João Martins de Mello-Neto
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  2. Mayla Kezy Silva Teixeira
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  3. Glaucia Schuindt Teixeira
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  4. Eduardo José Veras Lourenço
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  5. Daniel Moraes Telles
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  6. Ronaldo Lira-Junior
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  7. Deepak Ipe
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  8. Raj G. Nair
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  9. Elisabeth Almer Boström
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  10. Carlos Marcelo Figueredo
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Contributions

CMSF, EJVL, DMT and RLJ conceived the ideas; MKST and GST collected the data; JMMN, DI, CMSF and EAB analysed the data, and RGN, CMSF, JMMN, MKST and GST led the writing.

Corresponding author

Correspondence to Carlos Marcelo Figueredo.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by University Hospital Pedro Ernesto—UERJ, Rio de Janeiro, Brazil (HUPE‐UERJ) (REF: 20220219.4.0000.5259). All procedures performed in the study were in accordance with the 1964 Helsinki declaration and its later amendments.

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Informed consent was obtained from all individual participants included in the study.

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de Mello-Neto, J.M., Teixeira, M.K.S., Teixeira, G.S. et al. Peri-implant treatment reduces the salivary levels of Colony stimulator factor-1 and S100A8/A9. Odontology 109, 540–546 (2021). https://doi.org/10.1007/s10266-020-00570-4

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  • DOI: https://doi.org/10.1007/s10266-020-00570-4

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