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Significant prognostic factors affecting treatment outcomes of salivary gland carcinoma: a multicenter retrospective analysis

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Abstract

The purpose of this study was to investigate the prognostic factor in salivary gland carcinoma patients. Clinical and pathological data of 211 consecutive patients who treated with curative intent were analyzed. The overall survival (OS) rate, local control rate, and distant metastasis rate were calculated. To examine a prognostic factor in salivary gland carcinoma patients, a multivariate analysis was performed. The 5-year-OS rate was 84.0%, and 10-year was 69.2%. The 5-year-local control rate was 84.6%, and 10-year was 70.1%. The 5-year-distant metastasis rate was 16.9%, and 10-year was 21.1%. In a multivariate analysis, the OS rate was affected by pN(+), high-grade malignancy, and primary tumor size. The local control was affected by the primary tumor size, high-grade malignancy, and the status of the surgical margin. The primary tumor size and pN(+) were associated with the distant metastasis. The results of this study suggested that pN(+), malignancy grade, primary tumor size, and the margin status might affect the prognosis of salivary gland carcinoma patients. Postoperative radiotherapy and adjuvant chemotherapy were suggested the possibility of contribution to the good prognosis of salivary gland carcinoma patients.

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Authors and Affiliations

  1. Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

    Shin-ichi Yamada, Hiroshi Kurita & Takahiro Kamata

  2. Department of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, 840 Shijo-Cho, Kashihara, 634-8521, Japan

    Tadaaki Kirita & Nobuhiro Yamakawa

  3. Department of Oral and Maxillofacial Surgery, Keiyukai Sapporo Hospital, 14-Kita1-1 Shiraishiku Hondori, Sapporo, 003-0027, Japan

    Michihiro Ueda & Tetsuro Yamashita

  4. Department of Oral and Maxillofacial Surgery, Division of Surgery, Tokai University School of Medicine, 4-1-1 Kitakaname, Hiratsuka, Japan

    Yoshihide Ota & Mitsunobu Otsuru

  5. First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Japan

    Masaya Okura & Tomonao Aikawa

  6. Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan

    Masahiro Umeda

Authors
  1. Shin-ichi Yamada
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  2. Hiroshi Kurita
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  3. Takahiro Kamata
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  4. Tadaaki Kirita
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  5. Michihiro Ueda
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  6. Tetsuro Yamashita
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  7. Yoshihide Ota
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  8. Mitsunobu Otsuru
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  9. Nobuhiro Yamakawa
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  10. Masaya Okura
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  11. Tomonao Aikawa
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  12. Masahiro Umeda
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Correspondence to Hiroshi Kurita.

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Yamada, Si., Kurita, H., Kamata, T. et al. Significant prognostic factors affecting treatment outcomes of salivary gland carcinoma: a multicenter retrospective analysis. Odontology 106, 96–102 (2018). https://doi.org/10.1007/s10266-017-0318-1

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  • DOI: https://doi.org/10.1007/s10266-017-0318-1

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