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Economic evaluations of pharmacist-led medication review in outpatients with hypertension, type 2 diabetes mellitus, and dyslipidaemia: a systematic review

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Abstract

Objectives

To evaluate the health economics evidence based on randomized controlled trials of pharmacist-led medication review in pharmacotherapy managed cardiovascular disease risk factors, specifically, hypertension, type-2 diabetes mellitus and dyslipidaemia in ambulatory settings and to provide recommendations for future evaluations.

Methods

A systematic review was carried out according to the Cochrane Handbook for Systematic Reviews. PubMed (Medline), Scopus, Web of Science, National Health System Economic Evaluation Database (NHS EED), Cochrane Library, and Econlit were searched and screened by two independent authors. Incremental cost-effectiveness ratio was the main outcome. Risk of bias was assessed with the Effective Practice and Organisation of Care tool by the Cochrane Collaboration. Economic evaluation quality was assessed with the he Consensus Health Economic Criteria list (CHEC list).

Results

5636 records were found, and 174 were retrieved for full-text review yielding 11 articles. Eight articles deemed the intervention as cost effective and two as dominant. Two cost–utility analyses were performed yielding ICERs of $612.7 and $59.8 per QALY. Four articles were considered to perform a high-quality economic evaluation and four had a low risk of bias. Future economic evaluations should consider cost–utility analysis, to describe usual care thoroughly, and use time horizons that capture the effect of cardiovascular disease prevention, a societal perspective and uncertainty analysis.

Conclusion

Pharmacist-led medication review has proven to be cost effective in various studies in different settings. Policy decision makers are advised to undertake local economic evaluations reflecting the gaps observed in this systematic review and published literature. If this is not possible, a transferability assessment should be conducted.

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Authors and Affiliations

  1. Graduate School of Health, University of Technology Sydney, Broadway, PO Box 123, Sydney, NSW, 2007, Australia

    Antonio Ahumada-Canale, Francisco J. Martinez-Mardones & Victoria Garcia-Cardenas

  2. Oncology Institute, Arturo López Pérez Foundation, Santiago, Chile

    Camila Quirland

  3. Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile

    José Cristian Plaza-Plaza

  4. Emeritus Professor University of Sydney, Sydney, NSW, Australia

    Shalom Benrimoj

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  1. Antonio Ahumada-Canale
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Ahumada-Canale, A., Quirland, C., Martinez-Mardones, F.J. et al. Economic evaluations of pharmacist-led medication review in outpatients with hypertension, type 2 diabetes mellitus, and dyslipidaemia: a systematic review. Eur J Health Econ 20, 1103–1116 (2019). https://doi.org/10.1007/s10198-019-01080-z

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