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Angiotensin II and post-streptococcal glomerulonephritis

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Abstract

Background

Post-streptococcal glomerulonephritis (PSGN) is a consequence of the infection by group A beta-hemolytic streptococcus. During this infection, various immunological processes generated by streptococcal antigens are triggered, such as the induction of antibodies and immune complexes. This activation of the immune system involves both innate and acquired immunity. The immunological events that occur at the renal level lead to kidney damage with chronic renal failure as well as resolution of the pathological process (in most cases).

Summary

Angiotensin II (Ang II) is a molecule with vasopressor and pro-inflammatory capacities, being an important factor in various inflammatory processes. During PSGN some events are defined that make Ang II conceivable as a molecule involved in the inflammatory processes during the disease.

Conclusion

This review is focused on defining which reported events would be related to the presence of this hormone in PSGN.

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Acknowledgements

We thank Instituto de Investigaciones Clínicas Dr. Américo Negrette, Facultad de Medicina, Universidad de Zulia, Maracaibo, Venezuela.

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Authors and Affiliations

  1. Facultad de Medicina, Instituto de Investigaciones Clínicas “Dr. Américo Negrette”, Universidad del Zulia, Apartado Postal: 23, MaracaiboZulia, 4001-A, Venezuela

    Jesus A. Mosquera-Sulbaran, Yenddy Carrero & Juan Pablo Hernandez-Fonseca

  2. Facultad de Medicina, Cátedra de Inmunología, Escuela de Bioanálisis, Universidad del Zulia, Maracaibo, Venezuela

    Adriana Pedreañez

  3. Servicio de Microscopia Electrónica del Centro Nacional de Biotecnología, CNB-CSIC, Madrid, Spain

    Juan Pablo Hernandez-Fonseca

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  1. Jesus A. Mosquera-Sulbaran
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by JAM-S, AP, YC and JPH-F. The first draft of the manuscript was written by JAM-S and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Mosquera-Sulbaran, J.A., Pedreañez, A., Carrero, Y. et al. Angiotensin II and post-streptococcal glomerulonephritis. Clin Exp Nephrol 28, 359–374 (2024). https://doi.org/10.1007/s10157-023-02446-7

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