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Factors predicting the recovery from acute kidney injury in children with primary nephrotic syndrome

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Abstract

Background

The prognosis of acute kidney injury (AKI) varies in children with nephrotic syndrome (NS), data on factors predicting the recovery and recurrence of AKI in children with NS are limited. This study aimed to explore the possible factors predicting the recovery from and recurrence of AKI in children with primary NS.

Methods

Children with primary NS complicated with AKI from 1993 to 2017 in a single centre were reviewed retrospectively. The clinical pictures and possible factors predicting the recovery from and recurrence of AKI in children with primary NS were investigated.

Results

Sixty-eight episodes of AKI in 59 children with NS were analysed: 88.2% of AKI recovered within 3 months, and 2.9% of AKI did not recover after 3 months. Survival analysis revealed that leucocyturia is significantly related to the AKI recovery time (P = 0.001), and children with leucocyturia [22 (4, 79) days] recovered significantly slower than did children without leucocyturia [12.0 (2, 39) days]. Renal tubular and interstitial injury were prominent in children with leucocyturia, and 11.9% of children with index AKI experienced the recurrence of AKI.

Conclusions

Most episodes of AKI that occurred in children with NS recovered completely. Leucocyturia is a significant factor predicting the recovery time of AKI.

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Authors and Affiliations

  1. Department of Pediatrics, Peking University First Hospital, No.1 Xi An Men Da Jie, Beijing, China

    Na Guan, Yong Yao, Huijie Xiao, Jie Ding, Xuhui Zhong, Fang Wang, Xiaoyu Liu, Hongwen Zhang & Baige Su

Authors
  1. Na Guan
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  2. Yong Yao
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  3. Huijie Xiao
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  4. Jie Ding
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  5. Xuhui Zhong
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  6. Fang Wang
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  7. Xiaoyu Liu
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  8. Hongwen Zhang
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  9. Baige Su
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Contributions

Na Guan was a major contributor in study design, data collection and writing the manuscript. Yong Yao designed the investigation, revised the manuscript, approved the final version to be submitted and is responsible for all aspects of the work. Huijie Xiao, Jie Ding, Xuhui Zhong, Fang Wang, Xiaoyu Liu, Hongwen Zhang, Baige Su contributed to data collection and discussion of this study.

Corresponding author

Correspondence to Yong Yao.

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Conflict of interest

The authors have no conflicts of interest to declare.

Ethical statement

This study was approved by the Ethical Committee of Peking University First Hospital.

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Cite this article

Guan, N., Yao, Y., Xiao, H. et al. Factors predicting the recovery from acute kidney injury in children with primary nephrotic syndrome. Clin Exp Nephrol 25, 1011–1017 (2021). https://doi.org/10.1007/s10157-021-02074-z

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  • DOI: https://doi.org/10.1007/s10157-021-02074-z

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