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Assessment of kidney function in children by enzymatic determination of 2- or 24-h creatinine clearance: comparison with inulin clearance

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An Erratum to this article was published on 22 August 2017

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Abstract

Background

Although renal inulin clearance (Cin) is the gold standard for evaluation of kidney function, it cannot be measured easily. Therefore, creatinine clearance (Ccr) is often used clinically to evaluate kidney function. Enzymatically measured Ccr was recently found to be much higher than Cin because of the tubular secretion of creatinine (Cr). This study compared three measures of renal clearance, inulin, 2-h Ccr, and 24-h Ccr, in children.

Methods

Kidney function was evaluated in 76 children (51 males and 25 females) aged 1 month to 18 years with chronic kidney disease (CKD) by three renal clearance methods at almost the same time.

Results

Correlations between each pair of three renal clearance measurements were determined. Approximate glomerular filtration rate (GFR) was equal to 62 % of 2-h Ccr or 76 % of 24-h Ccr.

Conclusion

Cr secretion by renal tubules was approximately 50 % of the GFR. In this study, we indicate that the measurements of 2-h Ccr or 24-h Ccr do not show true GFR but we could infer approximate GFR from the values. The use of 2- or 24-h Ccr might contribute to the treatment of pediatric CKD patients.

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Change history

  • 22 August 2017

    An erratum to this article has been published.

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Acknowledgments

This study was supported financially by the Kidney Foundation, Japan, which enabled us to examine blood and urine specimens. Human rights were fully respected in conducting this study in accordance with the Declaration of Helsinki. All subjects gave their informed consent prior to their inclusion in the study.

Author information

Authors and Affiliations

  1. Department of Pediatric Nephrology, Aichi Children’s Health and Medical Center, 426 7-chome, Morioka-cho, Obu, Aichi, 474-8710, Japan

    Osamu Uemura, Takuhito Nagai, Satoshi Yamakawa, Yoshiko Hibi, Yasuhito Yamasaki, Masaki Yamamoto, Masaru Nakano, Naoyuki Iwata & Satoshi Hibino

  2. Department of Clinical Research, Tokyo Metropolitan Children’s Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan

    Tetsuji Kaneko

  3. Department of Clinical Medicine, Japanese Red Cross Toyota College of Nursing, 12-33 Nanamagari, Hakusan-cho, Toyota, Aichi, 471-8565, Japan

    Osamu Uemura

Authors
  1. Osamu Uemura
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  2. Takuhito Nagai
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  3. Satoshi Yamakawa
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  4. Tetsuji Kaneko
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  5. Yoshiko Hibi
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  6. Yasuhito Yamasaki
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  7. Masaki Yamamoto
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  8. Masaru Nakano
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  9. Naoyuki Iwata
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  10. Satoshi Hibino
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Corresponding author

Correspondence to Osamu Uemura.

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The authors have declared that no conflict of interest exists.

Additional information

An erratum to this article is available at https://doi.org/10.1007/s10157-017-1445-2.

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Uemura, O., Nagai, T., Yamakawa, S. et al. Assessment of kidney function in children by enzymatic determination of 2- or 24-h creatinine clearance: comparison with inulin clearance. Clin Exp Nephrol 20, 462–468 (2016). https://doi.org/10.1007/s10157-015-1166-3

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  • DOI: https://doi.org/10.1007/s10157-015-1166-3

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