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Serum ferritin is associated with progression of peripheral arterial disease in hemodialysis patients

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Abstract

Background

Dialysis patients received intravenous iron to treat anemia and had high prevalence of peripheral artery disease (PAD). We hypothesized that high iron status might associate with the progression of PAD among hemodialysis patients. Therefore, we evaluated the relationship between iron status and progression of PAD.

Methods

We measured iron status in 74 hemodialysis patients and studied the association with clinical, biochemical, and vascular parameters including progression of PAD measured by ankle-brachial index (ABI) over 3 years.

Results

Mean baseline ABI was 1.03 ± 0.18. Mean ABI at 3 years was 0.95 ± 0.20. Mean ∆ABI (change in ABI after 3 years) was −0.08 ± 0.14. Serum ferritin was negatively correlated with baseline ABI (r = −0.232, p = 0.046). After 3 years, ∆ABI was negatively associated with 3-year averaged serum ferritin, phosphorus, and calcium–phosphate product (Ca × P) (r = −0.253, p = 0.029; r = −0.278, p = 0.016; r = −0.288, p = 0.013; respectively). After an adjusted model, 3-year averaged serum ferritin and Ca × P remained the significant determinants of ∆ABI (β = −0.234, p = 0.038; β = −0.271, p = 0.017; respectively). ∆ABI was significantly different between 3-year averaged serum ferritin level ≥600 and <600 ng/mL (p = 0.032).

Conclusions

In hemodialysis patients, high serum ferritin associates with progression of PAD, especially among those with high Ca x P level.

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Abbreviations

ABI:

Ankle-brachial index

∆ABI:

Difference between 3-year ABI and baseline ABI

Ca x P:

Calcium–phosphate product

CVD:

Cardiovascular disease

DM:

Diabetes mellitus

PAD:

Peripheral artery disease

PTH:

Parathyroid hormone

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Conflict of interest

The authors declared no conflicts of interest relevant to this manuscript.

Author information

Authors and Affiliations

  1. Department of Diagnostic Radiology, Tainan Sinlau Hospital, No. 57, 1 Sec., Dongmen Rd., Tainan, Taiwan

    Chen-Tung Lien

  2. Department of Biotechnology, Southern Taiwan University, No. 1, Nan-Tai Street, Yung-Kung, Tainan, Taiwan

    Kao-Chang Lin

  3. Department of Neurology, Chi-Mei Medical Center, No. 901, Zhonghua Rd., Yonykang, Tainan, Taiwan

    Kao-Chang Lin

  4. Division of Nephrology, Tainan Sinlau Hospital, No. 57, 1 Sec., Dongmen Rd., Tainan, Taiwan

    Yueh-Feng Tsai, Lai-King Yu, Li-Hsueh Huang & Chien-An Chen

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  1. Chen-Tung Lien
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  2. Kao-Chang Lin
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  3. Yueh-Feng Tsai
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  4. Lai-King Yu
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Corresponding author

Correspondence to Chien-An Chen.

Additional information

C.-T. Lien and K.-C. Lin contributed equally to this work.

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Lien, CT., Lin, KC., Tsai, YF. et al. Serum ferritin is associated with progression of peripheral arterial disease in hemodialysis patients. Clin Exp Nephrol 19, 947–952 (2015). https://doi.org/10.1007/s10157-014-1074-y

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  • DOI: https://doi.org/10.1007/s10157-014-1074-y

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