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Significance of radiation therapy in the myxoid round-cell liposarcoma treatment regimen

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International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Background and purpose

Because myxoid liposarcomas are more radiosensitive than other soft tissue sarcomas, there have been several reports of 50 Gy preoperative radiation therapy combined with surgery, but the wound complication rate is reportedly high. We have performed preoperative irradiation at a reduced dose of 40 Gy and definitive radiation therapy for unresectable cases. This study aimed to report the tumor reduction rate and oncological results with a reduced dose of preoperative irradiation and the outcome of definitive irradiation for unresectable cases.

Materials and methods

Forty-one patients with myxoid liposarcoma treated in our institution between 2002 and 2021 were included. We examined the tumor volume shrinkage rate with preoperative radiation, compared complications and oncological outcomes between preoperative radiation and surgery-only cases, and investigated the prognosis and tumor shrinkage of definitive radiation cases.

Results

The total dose irradiated was 40 Gy except in two cases. The mean tumor volume reduction rate was 52.0%. A decreased dose of preoperative radiation did not worsen clinical outcomes with fewer complications. The total dose of definitive radiation was approximately 60 Gy. The mean tumor volume reduction rate was 55.0%. The tumor shrinkage maintenance rate was 100% in a median follow-up period of 50.5 months.

Conclusion

Preoperative radiation therapy for myxoid liposarcoma near vital organs is a good approach because even with a reduced dose of 40 Gy, significant tumor reduction and excellent results were achieved. Definitive radiation therapy is the recommended treatment for older patients with serious comorbidities or inoperable patients.

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Acknowledgements

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Funding

No financial support was received for this study.

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Authors and Affiliations

  1. Division of Orthopedic Oncology, Shizuoka Cancer Center Hospital, Shizuoka, Japan

    Akiyoshi Shimatani, Hirohisa Katagiri, Hideki Murata, Junji Wasa, Michihito Miyagi, Yosuke Honda & Mitsuru Takahashi

  2. Department of Orthopedic Surgery, Osaka Saiseikai Nakatsu Hospital, 2-10-39, Shibata, Kita-ku, Osaka-shi, Osaka, 530-0012, Japan

    Akiyoshi Shimatani

  3. Division of Radiation Oncology, Shizuoka Cancer Center Hospital, Shizuoka, Japan

    Hiroyuki Harada, Hirofumi Asakura & Tsuyoshi Onoe

Authors
  1. Akiyoshi Shimatani
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  2. Hirohisa Katagiri
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  3. Hideki Murata
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  4. Junji Wasa
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  5. Michihito Miyagi
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  6. Yosuke Honda
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  7. Mitsuru Takahashi
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  8. Hiroyuki Harada
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  9. Hirofumi Asakura
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  10. Tsuyoshi Onoe
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Contributions

Conceptualization, A.S., H.K.; methodology, A.S., H.K., Y.H.; formal analysis, A.S.; investigation, A.S., Y.H.; data curation, A.S., Y.H.; writing—original draft preparation, A.S.; writing—review and editing, H.K., T.O., H.M., J.W., M.M., H.H., H.A., M.T.; supervision, H.K.; project administration, A.S. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Akiyoshi Shimatani.

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Conflict of interest

None.

Ethical approval

This study was approved by the Shizuoka Cancer Center Hospital (approval number: J2021-173-2021-1-2), and all investigations were conducted in accordance with the ethical principles of the Shizuoka Cancer Center Hospital.

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Patients and their families provided written consent for the publication of patient data.

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Cite this article

Shimatani, A., Katagiri, H., Murata, H. et al. Significance of radiation therapy in the myxoid round-cell liposarcoma treatment regimen. Int J Clin Oncol (2024). https://doi.org/10.1007/s10147-024-02534-y

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  • DOI: https://doi.org/10.1007/s10147-024-02534-y

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