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Prognostic significance of β2-adrenergic receptor expression in patients with surgically resected colorectal cancer

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Abstract

Purpose

The β2-adrenergic receptor (β2AR) is highly expressed in various human cancers. The prognostic significance of its expression in patients with colorectal cancer (CRC) remains unclear. The aim of this study was to assess the prognostic role of β2AR expression in patients with surgically resected CRC.

Methods

One hundred and forty-seven patients with surgically resected CRC were examined using immunohistochemistry. The expression of β2AR was assessed in the specimens of resected primary tumors.

Results

β2AR was expressed in 52.3% of the patients’ tumors. β2AR expression was significantly associated with T factor, N factor, and tumor cell proliferation (Ki-67 labeling index). Univariate analysis demonstrated that T factor, N factor, tumor stage, lymphatic permeation, vascular invasion, perineural invasion, β2AR expression, and Ki-67 labeling index were significant prognostic factors for worse disease-free survival (DFS); all but T factor were also significant predictors for worse overall survival (OS). Multivariate analysis confirmed that expression of β2AR was a significant prognostic marker for predicting worse DFS and OS.

Conclusion

β2AR expression was identified as a significant independent prognostic factor in patients with surgically resected CRC.

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Acknowledgements

We thank Ms. Sawa Nagayama and Ms. Yukiko Sutoh in Gunma University Hospital for excellent technical assistant.

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Authors and Affiliations

  1. Department of General Surgical Science, Gunma University, Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, 371-8511, Gunma, Japan

    Hiroomi Ogawa, Yoko Motegi, Takehiko Yokobori, Takahiro Takada, Ryuji Kato, Katsuya Osone, Ryo Takahashi, Kunihiko Suga, Naoya Ozawa, Chika Katayama, Hiroshi Saeki & Ken Shirabe

  2. Department of Innovative Immune-Oncology Therapeutics, Gunma University, Graduate School of Medicine, Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Kyoichi Kaira & Takehiko Yokobori

  3. Department of Diagnostic Pathology, Gunma University, Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, 371-8511, Gunma, Japan

    Tetsunari Oyama

  4. Big Data Center for Integrative Analysis, Gunma University Initiative for Advance Research, 3-39-22 Showa-machi, Maebashi, 371-8511, Gunma, Japan

    Takayuki Asao

  5. Department of Dermatology, Gunma University, Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, 371-8511, Gunma, Japan

    Akira Shimizu

  6. Department of Human Pathology, Juntendo University, Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-0003, Tokyo, Japan

    Takashi Yao

  7. Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama University Hospital, 1397-1 Yamane, Hidaka-City, Saitama, 350-1298, Japan

    Kyoichi Kaira

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  1. Hiroomi Ogawa
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  2. Kyoichi Kaira
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  3. Yoko Motegi
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  10. Naoya Ozawa
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  12. Tetsunari Oyama
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  13. Akira Shimizu
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  14. Takashi Yao
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  15. Takayuki Asao
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  16. Hiroshi Saeki
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  17. Ken Shirabe
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Corresponding author

Correspondence to Kyoichi Kaira.

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Cite this article

Ogawa, H., Kaira, K., Motegi, Y. et al. Prognostic significance of β2-adrenergic receptor expression in patients with surgically resected colorectal cancer. Int J Clin Oncol 25, 1137–1144 (2020). https://doi.org/10.1007/s10147-020-01645-6

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  • DOI: https://doi.org/10.1007/s10147-020-01645-6

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