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A novel flow diverter device (Tubridge) for the treatment of intracranial aneurysms: a systematic review and meta-analysis

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Abstract

The flow diverter (FD) device has become a feasible and effective option for treating intracranial aneurysms. This study aimed to evaluate the efficacy and safety of Tubridge FD (TFD) in treating intracranial aneurysms and provide evidence for further research and clinical application. Electronic databases, including PubMed, Web of Science, Embase, and the Cochrane Library from inception to July 31, 2022, were searched. The eligible studies should include TFD investigations in treating intracranial aneurysms. Pooled technical success rate, complete occlusion rate, improvement rate, stable rate, symptom elimination rate, and adverse events rate were calculated with either the fixed-effects model or the random-effects model, depending on the results of tests for heterogeneity. Egger’s tests were performed to assess the potential publication bias. A total of 7 studies (145 patients) were included in this study. The pooled technical success rate was 0.98, the complete occlusion rate was 0.79, the improvement rate was 0.21, and the stable rate was 0.05. One included study reported that the surgery-related mortality rate in the Tubridge group was higher than that in the control group (3.66% vs. 1.61%), while the surgery-related morbidity rate in the Tubridge group was 2.4% and that in the control group was 0. Findings of this meta-analysis indicate that TFD manifests promising and effective performance with acceptable adverse events in the treatment of intracranial aneurysms.

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All data generated or analyzed during this study are included in this published article/as supplementary information files.

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  1. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610041, China

    Yingjun Fan, Jun Lei, Fan Fei, Jun Liu & Yanhui Liu

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Contributions

Conception and design: YF, YL, J LEI. Administrative support: YL. Provision of study materials or patients: YL, FF, J LIU. Collection and assembly of data: YF, J LEI, J LIU, FF. Data analysis and interpretation: YF, J LEI, J LIU, FF. Manuscript writing: All authors. Final approval of manuscript: All authors.

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Correspondence to Yanhui Liu.

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Supplementary information

ESM 1

Supplementary Figure S1. Pooled results of sensitivity analysis on technical success rates in studies included. (JPG 49 kb)

ESM 2

Supplementary Figure S2. Pooled results of sensitivity analysis on complete occlusion rates in studies included. (JPG 75 kb)

ESM 3

Supplementary Figure S3. Pooled results of sensitivity analysis on improvement rates in studies included. (JPG 56 kb)

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Fan, Y., Lei, J., Fei, F. et al. A novel flow diverter device (Tubridge) for the treatment of intracranial aneurysms: a systematic review and meta-analysis. Neurosurg Rev 46, 198 (2023). https://doi.org/10.1007/s10143-023-02100-6

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