Skip to main content

Advertisement

SpringerLink
Log in

Clinical outcomes after microsurgical resection of giant lateral ventricular meningiomas

  • Research
  • Published:
Neurosurgical Review Aims and scope Submit manuscript

Abstract

Giant lateral ventricular meningiomas (LVMs), with the largest diameter of at least 5 cm, form a distinct subset. The incidence of giant LVMs is considered to be relatively low. Here, we evaluated clinical characteristics, and clinical outcomes after microsurgical resection, especially functional outcomes and morbidity of giant LVMs. We retrospectively reviewed 49 patients with LVMs, including 18 giant LVMs from 2012 to 2020. And we analyzed clinical, histopathological, surgical, and outcome data at our institution. Giant LVMs were most commonly present in the fourth decade of patients with the male-to-female ratio of 1:2. The most common subtypes were transitional and fibrous. Most lesions were resected via the temporal or parieto-occipital approach in our series. The median volume of blood loss was higher in the giant group (900 vs. 600 ml, p = 0.02). Meanwhile, the median length of hospital stay was prolonged for giant LVMs (20.5 vs. 16.0 days, p < 0.01). The proportion of discharged functional deterioration was higher in giant LVMs (38.9% vs. 6.5%, p = 0.02). However, there was no statistical significance between functional deterioration and tumor size at long-term follow-up (p = 0.28). Giant LVMs patients suffered from neurological and regional complications more commonly, particularly from a postoperative hematoma (4/18 vs. 1/31), and hydrocephalus (2/18 vs. 0/31). Patients with giant LVMs had a high incidence of immediate functional deterioration after microsurgery, and there was no difference in functional deterioration between the giant and non-giant LVMS during long-term follow-up. Microsurgery entails a higher complication rate in giant LVMs. We need to pay special attention to preventing postoperative hematoma and hydrocephalus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Goldbrunner R, Stavrinou P, Jenkinson MD, Sahm F, Mawrin C, Weber DC et al (2021) EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol. 23:1821–1834. https://doi.org/10.1093/neuonc/noab150

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS (2021) CBTRUS Statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014-2018. Neuro Oncol. 23:iii1–iii105. https://doi.org/10.1093/neuonc/noab200

    Article  PubMed  PubMed Central  Google Scholar 

  3. Pereira BJA, de Almeida AN, Paiva WS, de Aguiar PHP, Teixeira MJ, Marie SKN (2020) Natural history of intraventricular meningiomas: systematic review. Neurosurg Rev. 43:513–523. https://doi.org/10.1007/s10143-018-1019-0

    Article  PubMed  Google Scholar 

  4. Grujicic D, Cavallo LM, Somma T, Illic R, Milicevic M, Raicevic S et al (2017) Intraventricular meningiomas: a series of 42 patients at a single institution and literature review. World Neurosurg. 97:178–188. https://doi.org/10.1016/j.wneu.2016.09.068

    Article  PubMed  Google Scholar 

  5. Guidetti B, Delfini R, Gagliardi FM, Vagnozzi R (1985) Meningiomas of the lateral ventricles. Clinical, neuroradiologic, and surgical considerations in 19 cases. Surg Neurol. 24:364–370. https://doi.org/10.1016/0090-3019(85)90292-7

    Article  CAS  PubMed  Google Scholar 

  6. Haeren RHL, Rautalin I, Schwartz C, Korja M, Niemela M (2021) Surgery on giant meningiomas in very old patients entails frequent postoperative intracranial hemorrhages and atypical histopathology. J Neurooncol. 152:195–204. https://doi.org/10.1007/s11060-020-03693-4

    Article  PubMed  PubMed Central  Google Scholar 

  7. Narayan V, Bir SC, Mohammed N, Savardekar AR, Patra DP, Nanda A (2018) Surgical management of giant intracranial meningioma: operative nuances, challenges, and outcome. World Neurosurg. 110:e32–e41. https://doi.org/10.1016/j.wneu.2017.09.184

    Article  PubMed  Google Scholar 

  8. Schwartz C, Jahromi BR, Lonnrot K, Hafez A, Maekawa H, Lehecka M et al (2021) Clinical outcome after microsurgical resection of intraventricular trigone meningiomas: a single-centre analysis of 20 years and literature overview. Acta Neurochir (Wien). 163:677–687. https://doi.org/10.1007/s00701-020-04520-5

    Article  PubMed  Google Scholar 

  9. Nanda A, Bir SC, Maiti T, Konar S (2016) Intraventricular meningioma: technical nuances in surgical management. World Neurosurg. 88:526–537. https://doi.org/10.1016/j.wneu.2015.10.071

    Article  PubMed  Google Scholar 

  10. Wang X, Cai BW, You C, He M (2007) Microsurgical management of lateral ventricular meningiomas: a report of 51 cases. Minim Invasive Neurosurg. 50:346–349. https://doi.org/10.1055/s-2007-993205

    Article  CAS  PubMed  Google Scholar 

  11. Delfini R, Acqui M, Oppido PA, Capone R, Santoro A, Ferrante L (1991) Tumors of the lateral ventricles. Neurosurg Rev. 14:127–133. https://doi.org/10.1007/bf00313037

    Article  CAS  PubMed  Google Scholar 

  12. Menon G, Nair S, Sudhir J, Rao R, Easwer HV, Krishnakumar K (2009) Meningiomas of the lateral ventricle - a report of 15 cases. Br J Neurosurg. 23:297–303. https://doi.org/10.1080/02688690902721862

    Article  CAS  PubMed  Google Scholar 

  13. Ma J, Cheng L, Wang G, Lin S (2014) Surgical management of meningioma of the trigone area of the lateral ventricle. World Neurosurg. 82:757–769. https://doi.org/10.1016/j.wneu.2014.05.026

    Article  PubMed  Google Scholar 

  14. Li Z, Li H, Jiao Y, Ma J, Wang S, Cao Y et al (2018) Clinical features and long-term outcomes of pediatric intraventricular meningiomas: data from a single neurosurgical center. Neurosurg Rev. 41:525–530. https://doi.org/10.1007/s10143-017-0884-2

    Article  PubMed  Google Scholar 

  15. Samanci Y, Oktug D, Yilmaz M, Sengoz M, Peker S (2020) Efficacy of gamma knife radiosurgery in the treatment of intraventricular meningiomas. J Clin Neurosci. 80:38–42. https://doi.org/10.1016/j.jocn.2020.08.016

    Article  PubMed  Google Scholar 

  16. Jiang Y, Lv L, Li J, Ma W, Chen C, Zhou P et al (2020) Clinical features, radiological findings, and treatment outcomes of high-grade lateral ventricular meningiomas: a report of 26 cases. Neurosurg Rev. 43:565–573. https://doi.org/10.1007/s10143-019-01078-4

    Article  PubMed  Google Scholar 

  17. Maiuri F, Mariniello G, Barbato M, Corvino S, Guadagno E, Chiariotti L et al (2021) Malignant intraventricular meningioma: literature review and case report. Neurosurg Rev. https://doi.org/10.1007/s10143-021-01585-3

  18. Lyngdoh BT, Giri PJ, Behari S, Banerji D, Chhabra DK, Jain VK (2007) Intraventricular meningiomas: a surgical challenge. J Clin Neurosci. 14:442–448. https://doi.org/10.1016/j.jocn.2006.01.005

    Article  PubMed  Google Scholar 

  19. Fornari M, Savoiardo M, Morello G, Solero CL (1981) Meningiomas of the lateral ventricles. Neuroradiological and surgical considerations in 18 cases. J Neurosurg 54:64–74. https://doi.org/10.3171/jns.1981.54.1.0064

    Article  CAS  PubMed  Google Scholar 

  20. Nakamura M, Roser F, Bundschuh O, Vorkapic P, Samii M (2003) Intraventricular meningiomas: a review of 16 cases with reference to the literature. Surgical Neurology. 59:490–503. https://doi.org/10.1016/s0090-3019(03)00082-x

    Article  Google Scholar 

  21. Jamshidi AO, Beer-Furlan A, Hardesty DA, Ditzel Filho LFS, Prevedello LM, Prevedello DM (2021) Management of large intraventricular meningiomas with minimally invasive port technique: a three-case series. Neurosurg Rev. 44:2369–2377. https://doi.org/10.1007/s10143-020-01409-w

    Article  PubMed  Google Scholar 

  22. Yu SQ, Wang JS, Chen SY, Liu XM, Li Y, Ding YM et al (2015) Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination. Chin Med J (Engl) 128:186–190. https://doi.org/10.4103/0366-6999.149194

    Article  PubMed  Google Scholar 

  23. Lekht I, Brauner N, Bakhsheshian J, Chang KE, Gulati M, Shiroishi MS et al (2016) Versatile utilization of real-time intraoperative contrast-enhanced ultrasound in cranial neurosurgery: technical note and retrospective case series. Neurosurg Focus. 40:E6. https://doi.org/10.3171/2015.11.FOCUS15570

    Article  PubMed  PubMed Central  Google Scholar 

  24. Goel A, Vutha R, Shah A, Singh K, Goel N, Shenoy A et al (2021) Large lateral intraventricular tumors - outcome of radical surgery. J Clin Neurosci. 88:205–212. https://doi.org/10.1016/j.jocn.2021.03.040

    Article  PubMed  Google Scholar 

  25. Dobran M, Marini A, Nasi D, Liverotti V, Benigni R, Iacoangeli M et al (2018) Surgical treatment and outcome in patients over 80 years old with intracranial meningioma. Clin Neurol Neurosurg. 167:173–176. https://doi.org/10.1016/j.clineuro.2018.02.024

    Article  PubMed  Google Scholar 

  26. Fornari M, Savoiardo M, Morello G, Solero CL (1981) Meningiomas of the lateral ventricles. Neuroradiological and surgical considerations in 18 cases. J Neurosurg. 54:64–74. https://doi.org/10.3171/jns.1981.54.1.0064

    Article  CAS  PubMed  Google Scholar 

  27. de Almeida AN, Pereira BJA, Pires Aguiar PH, Paiva WS, Cabrera HN, da Silva CC et al (2017) Clinical outcome, tumor recurrence, and causes of death: a long-term follow-up of surgically treated meningiomas. World Neurosurg. 102:139–143. https://doi.org/10.1016/j.wneu.2017.03.009

    Article  PubMed  Google Scholar 

  28. Tyagi G, Bhat DI, Devi BI, Shukla D (2019) Multiple Remote sequential supratentorial epidural hematomas-an unusual and rare complication after posterior fossa surgery. World Neurosurg. 128:83–90. https://doi.org/10.1016/j.wneu.2019.04.228

    Article  PubMed  Google Scholar 

  29. Lin Z, Wang C, Gao Z, Li X, Lan F, Liu T et al (2019) Clinical characteristics of and treatment protocol for trapped temporal horn following resection of lateral ventricular trigone meningioma: a single-center experience. J Neurosurg. 132:481–490. https://doi.org/10.3171/2018.11.jns182710

    Article  PubMed  Google Scholar 

  30. Lin Z, Zhang X, Shen S, Gao Z, Guan C, Liu T et al (2020) Postoperative delayed trapped temporal horn in patients with lateral ventricular trigone meningioma: risk factors, surgical management, and literature review. Eur J Surg Oncol. 46:2324–2330. https://doi.org/10.1016/j.ejso.2020.04.033

    Article  PubMed  Google Scholar 

  31. Wang Y, Lin Z, Li Z, Zhao M, Hu M, Zhang H et al (2016) The incidence and risk factors of postoperative entrapped temporal horn in trigone meningiomas. World Neurosurg. 90:511–517. https://doi.org/10.1016/j.wneu.2016.03.040

    Article  PubMed  Google Scholar 

Download references

Data availability

Not applicable

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

    Dan Cao, Yibo Ou, Xu Chen, Zhengqian Guo & Jian Chen

  2. Department of Neurosurgery Intensive Care Unit, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, China

    Yong Chen

Authors
  1. Dan Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yibo Ou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xu Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhengqian Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jian Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Dan Cao: conceptualization, methodology, writing—original draft. Yibo Ou and Xu Chen: writing—review and editing. Zhengqian Guo and Yong Chen: date curation, softwarea. Jian Chen: supervision

Corresponding author

Correspondence to Jian Chen.

Ethics declarations

Ethical approval and consent to participate

The study was performed under Institutional Review Board approval and did not require patient consent (file number:TJ-IRB20220327).

Human and animal ethics

Not applicable

Consent for publication

Not applicable

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

ESM 1

(DOCX 2075 kb)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cao, D., Ou, Y., Chen, X. et al. Clinical outcomes after microsurgical resection of giant lateral ventricular meningiomas. Neurosurg Rev 46, 33 (2023). https://doi.org/10.1007/s10143-022-01932-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10143-022-01932-y

Keywords

Search

Navigation