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Risk factors for the development of degenerative cervical myelopathy: a review of the literature

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Abstract

Degenerative cervical myelopathy (DCM) encompasses various pathological conditions causing spinal cord (SC) impairment, including spondylosis (multiple level degeneration), degenerative disc disease (DDD), ossification of the posterior longitudinal ligament (OPLL), and ossification of the ligamentum flavum (OLF). It is considered the most common cause of SC dysfunction among the adult population. The degenerative phenomena of DDD, spondylosis, OPLL and OLF, is likely due to both inter-related and distinct factors. Age, cervical alignment, and range of motion, as well as congenital factors such as cervical cord-canal mismatch due to congenital stenosis, Klippel-Feil, Ehler-Danlos, and Down syndromes have been previously reported as potential factors of risk for DCM. The correlation between some comorbidities, such as rheumatoid arthritis and movement disorders (Parkinson disease and cervical dystonia) and DCM, has also been reported; however, the literature remains scare. Other patient-specific factors including smoking, participation in contact sports, regular heavy load carrying on the head, and occupation (e.g. astronauts) have also been suggested as potential risk of myelopathy development. Most of the identified DCM risk factors remain poorly studied however. Further researches will be necessary to strengthen the current knowledge on the subject, especially concerning physical labors in order to identify patients at risk and to develop an effective treatment strategy for preventing this increasing prevalent disorder.

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References

  1. Akter F, Kotter M (2018) Pathobiology of degenerative cervical myelopathy. Neurosurg Clin N Am 29:13–19. https://doi.org/10.1016/j.nec.2017.09.015

    Article  PubMed  Google Scholar 

  2. Alare K, Omoniyo T, Adekanle T Postural Predisposition to Cervical spondylosis. spine 11:13

  3. Ali FE, Al-Bustan MA, Al-Busairi WA, Al-Mulla FA, Esbaita EY (2006) Cervical spine abnormalities associated with Down syndrome. Int Orthop 30:284–289. https://doi.org/10.1007/s00264-005-0070-y

    Article  PubMed  PubMed Central  Google Scholar 

  4. Al-Rawahi M, Luo J, Pollintine P, Dolan P, Adams MA (2011) Mechanical function of vertebral body osteophytes, as revealed by experiments on cadaveric spines. Spine 36:770–777. https://doi.org/10.1097/BRS.0b013e3181df1a70

    Article  PubMed  Google Scholar 

  5. Ames CP, Blondel B, Scheer JK, Schwab FJ, Le Huec J-C, Massicotte EM, Patel AA, Traynelis VC, Kim HJ, Shaffrey CI, Smith JS, Lafage V (2013) Cervical Radiographical alignment: comprehensive assessment techniques and potential importance in cervical myelopathy. Spine 38:S149–S160. https://doi.org/10.1097/BRS.0b013e3182a7f449

    Article  PubMed  Google Scholar 

  6. Bajwa NS, Toy JO, Young EY, Ahn NU (2012) Establishment of parameters for congenital stenosis of the cervical spine: an anatomic descriptive analysis of 1066 cadaveric specimens. Eur Spine J 21:2467–2474. https://doi.org/10.1007/s00586-012-2437-2

    Article  PubMed  PubMed Central  Google Scholar 

  7. Baron EM, Young WF (2007) Cervical spondylotic myelopathy. Neurosurgery 60:S1-35-S1-41. https://doi.org/10.1227/01.NEU.0000215383.64386.82

    Article  Google Scholar 

  8. Bednarik J, Kadanka Z, Dusek L, Kerkovsky M, Vohanka S, Novotny O, Urbanek I, Kratochvilova D (2008) Presymptomatic spondylotic cervical myelopathy: an updated predictive model. Eur Spine J 17:421–431. https://doi.org/10.1007/s00586-008-0585-1

    Article  PubMed  PubMed Central  Google Scholar 

  9. Beighton P, Paepe AD, Steinmann B, Tsipouras P, Wenstrup RJ (1998) Ehlers-Danlos syndromes: revised nosology, Villefranche, 1997. Am J Med Genet 77:31–37. https://doi.org/10.1002/(SICI)1096-8628(19980428)77:1%3c31::AID-AJMG8%3e3.0.CO;2-O

    Article  CAS  PubMed  Google Scholar 

  10. Bejiqi R, Retkoceri R, Bejiqi H, Zeka N (2015) Klippel-Feil syndrome associated with congenital heart disease presentation of cases and a review of the current literature. Open Access Macedonian J Med Sci. https://doi.org/10.3889/oamjms.2015.022

    Article  Google Scholar 

  11. Benatru I, Vaugoyeau M, Azulay J-P (2008) Postural disorders in Parkinson’s disease. Neurophysiol Clin/Clin Neurophysiol 38:459–465. https://doi.org/10.1016/j.neucli.2008.07.006

    Article  CAS  Google Scholar 

  12. Benoist M (2003) Natural history of the aging spine. Eur Spine J 12(Suppl 2):S86-89. https://doi.org/10.1007/s00586-003-0593-0

    Article  PubMed  PubMed Central  Google Scholar 

  13. Binder AI (2007) Cervical spondylosis and neck pain. BMJ 334:527–531. https://doi.org/10.1136/bmj.39127.608299.80

    Article  PubMed  PubMed Central  Google Scholar 

  14. Bosma GPTh, van Buchem MA, Voormolen JHC, van Biezen FC, Brouwer OF (1999) Cervical spondylarthrotic myelopathy with early onset in Down’s syndrome: five cases and a review of the literature. J Intellect Disabil Res 43:283–288. https://doi.org/10.1046/j.1365-2788.1999.00212.x

    Article  PubMed  Google Scholar 

  15. Breidahl P (1969) Ossification of the posterior longitudinal ligament in the cervical spine: the Japanese disease occurring in patients of british descent. Australas Radiol 13:311–313. https://doi.org/10.1111/j.1440-1673.1969.tb01614.x

    Article  CAS  PubMed  Google Scholar 

  16. Buckwalter JA (1995) Aging and degeneration of the human intervertebral disc. Spine 20:1307–1314. https://doi.org/10.1097/00007632-199506000-00022

    Article  CAS  PubMed  Google Scholar 

  17. Buell TJ, Buchholz AL, Quinn JC, Shaffrey CI, Smith JS (2018) Importance of sagittal alignment of the cervical spine in the management of degenerative cervical myelopathy. Neurosurg Clin N Am 29:69–82. https://doi.org/10.1016/j.nec.2017.09.004

    Article  PubMed  Google Scholar 

  18. Cabre P, Pascal-Moussellard H, Kaidomar S, Bucki B, Bardin T, Smadja D, Arfi S (2001) Six cases of cervical ligamentum flavum calcification in Blacks in the French West Indies. Joint Bone Spine 68:158–165. https://doi.org/10.1016/S1297-319X(00)00246-3

    Article  CAS  PubMed  Google Scholar 

  19. Carotti M, Salaffi F, Di Carlo M, Sessa F, Giovagnoni A (2019) Magnetic resonance imaging of the craniovertebral junction in early rheumatoid arthritis. Skeletal Radiol 48:553–561. https://doi.org/10.1007/s00256-018-3055-9

    Article  PubMed  Google Scholar 

  20. Castori M, Voermans NC (2014) Neurological manifestations of Ehlers-Danlos syndrome(s): a review. Iran J Neurol 13:190–208

    PubMed  PubMed Central  Google Scholar 

  21. Chachan S, Kasat NS, Keng PTL (2018) Cervical myelopathy secondary to combined ossification of ligamentum flavum and posterior longitudinal ligament—a case report. Int J Spine Surg 12:121–125. https://doi.org/10.14444/5018

    Article  PubMed  PubMed Central  Google Scholar 

  22. Chang H, Kong C-G, Won H-Y, Kim J-H, Park J-B (2010) Inter- and intra-observer variability of a cervical OPLL classification using reconstructed CT images. Clin Orthop Surg 2:8. https://doi.org/10.4055/cios.2010.2.1.8

    Article  PubMed  PubMed Central  Google Scholar 

  23. Chaput CD, Allred JJ, Pandorf JJ, Song J, Rahm MD (2013) The significance of facet joint cross-sectional area on magnetic resonance imaging in relationship to cervical degenerative spondylolisthesis. Spine J 13:856–861. https://doi.org/10.1016/j.spinee.2013.01.021

    Article  PubMed  Google Scholar 

  24. Clarke MJ, Cohen-Gadol AA, Ebersold MJ, Cabanela ME (2006) Long-term incidence of subaxial cervical spine instability following cervical arthrodesis surgery in patients with rheumatoid arthritis. Surg Neurol 66:136–140. https://doi.org/10.1016/j.surneu.2005.12.037

    Article  PubMed  Google Scholar 

  25. Claypool DW, Duane DD, Ilstrup DM, Melton LJ (1995) Epidemiology and outcome of cervical dystonia (spasmodic torticollis) in Rochester, Minnesota. Mov Disord 10:608–614. https://doi.org/10.1002/mds.870100513

    Article  CAS  PubMed  Google Scholar 

  26. Countee RW, Vijayanathan T (1979) Congenital stenosis of the cervical spine: diagnosis and management. J Natl Med Assoc 71:257–264

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Davies BM, Mowforth OD, Smith EK, Kotter MR (2018) Degenerative cervical myelopathy. BMJ k186. https://doi.org/10.1136/bmj.k186

  28. De Paepe A, Malfait F (2012) The Ehlers-Danlos syndrome, a disorder with many faces. Clin Genet 82:1–11. https://doi.org/10.1111/j.1399-0004.2012.01858.x

    Article  CAS  PubMed  Google Scholar 

  29. Demarin V, Morovic S, Béné R (2014) Neuroplasticity. Period Biol 116:209–211

    Google Scholar 

  30. Dimar JR, Carreon LY (2012) Spinal deformity in Down syndrome. Spine Deformity 1:75–84. https://doi.org/10.1016/j.jspd.2012.05.002

    Article  Google Scholar 

  31. Dong Y, Holly LT, Albistegui-Dubois R, Yan X, Marehbian J, Newton JM, Dobkin BH (2008) Compensatory cerebral adaptations before and evolving changes after surgical decompression in cervical spondylotic myelopathy: laboratory investigation. SPI 9:538–551. https://doi.org/10.3171/SPI.2008.10.0831

    Article  Google Scholar 

  32. Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group (2000) A prevalence study of primary dystonia in eight European countries. J Neurol 247:787–792. https://doi.org/10.1007/s004150070094

    Article  Google Scholar 

  33. Ernst CW, Stadnik TW, Peeters E, Breucq C, Osteaux MJC (2005) Prevalence of annular tears and disc herniations on MR images of the cervical spine in symptom free volunteers. Eur J Radiol 55:409–414. https://doi.org/10.1016/j.ejrad.2004.11.003

    Article  CAS  PubMed  Google Scholar 

  34. Fan Z, Cao Y, Lv G, Wang Y, Guo Z (2013) The effect of cigarette smoke exposure on spinal cord injury in rats. J Neurotrauma 30:473–479. https://doi.org/10.1089/neu.2012.2574

    Article  PubMed  PubMed Central  Google Scholar 

  35. Fassio A, Adami G, Idolazzi L, Giollo A, Viapiana O, Bosco E, Negrelli R, Sani E, Sandri D, Mantovani A, Targher G, Rossini M, Gatti D (2021) Diffuse idiopathic skeletal hyperostosis (DISH) in type 2 diabetes: a new imaging possibility and a new biomarker. Calcif Tissue Int 108:231–239. https://doi.org/10.1007/s00223-020-00768-2

    Article  CAS  PubMed  Google Scholar 

  36. Fehlings MG, Ibrahim A, Tetreault L, Albanese V, Alvarado M, Arnold P, Barbagallo G, Bartels R, Bolger C, Defino H, Kale S, Massicotte E, Moraes O, Scerrati M, Tan G, Tanaka M, Toyone T, Yukawa Y, Zhou Q, Zileli M, Kopjar B (2015) A global perspective on the outcomes of surgical decompression in patients with cervical spondylotic myelopathy: results from the prospective multicenter AOSpine international study on 479 patients. Spine 40:1322–1328. https://doi.org/10.1097/BRS.0000000000000988

    Article  PubMed  Google Scholar 

  37. Fehlings MG, Tetreault LA, Riew KD, Middleton JW, Aarabi B, Arnold PM, Brodke DS, Burns AS, Carette S, Chen R, Chiba K, Dettori JR, Furlan JC, Harrop JS, Holly LT, Kalsi-Ryan S, Kotter M, Kwon BK, Martin AR, Milligan J, Nakashima H, Nagoshi N, Rhee J, Singh A, Skelly AC, Sodhi S, Wilson JR, Yee A, Wang JC (2017) A clinical practice guideline for the management of patients with degenerative cervical myelopathy: recommendations for patients with mild, moderate, and severe disease and nonmyelopathic patients with evidence of cord compression. Glob Spine J 7:70S-83S. https://doi.org/10.1177/2192568217701914

    Article  Google Scholar 

  38. Fengbin Y, Deyu C, Xinwei W, Yu C, Jinhao M, Xinyuan L, Xiaowei L (2013) Trauma-induced spinal cord injury in cervical spondylotic myelopathy with or without lower cervical instability. J Clin Neurosci 20:419–422. https://doi.org/10.1016/j.jocn.2012.02.051

    Article  PubMed  Google Scholar 

  39. Fernandes NF, Schwartz RA (2008) A “hyperextensive” review of Ehlers-Danlos syndrome. Cutis 82:242–248

    PubMed  Google Scholar 

  40. Finney JG, Kryzanski JT (2017) Advanced myelopathy in people with Down syndrome. Int Med Rev Down Syndr 21:39–45. https://doi.org/10.1016/j.sdeng.2017.11.001

    Article  Google Scholar 

  41. Foley C, Killeen OG (2019) Musculoskeletal anomalies in children with Down syndrome: an observational study. Arch Dis Child 104:482–487. https://doi.org/10.1136/archdischild-2018-315751

    Article  PubMed  Google Scholar 

  42. Fujimori T, Le H, Hu SS, Chin C, Pekmezci M, Schairer W, Tay BK, Hamasaki T, Yoshikawa H, Iwasaki M (2015) Ossification of the posterior longitudinal ligament of the cervical spine in 3161 patients: a CT-based study. Spine 40:E394–E403. https://doi.org/10.1097/BRS.0000000000000791

    Article  PubMed  Google Scholar 

  43. Galbusera F, van Rijsbergen M, Ito K, Huyghe JM, Brayda-Bruno M, Wilke H-J (2014) Ageing and degenerative changes of the intervertebral disc and their impact on spinal flexibility. Eur Spine J. https://doi.org/10.1007/s00586-014-3203-4

    Article  PubMed  Google Scholar 

  44. Ganju A, Ondra SL, Shaffrey CI (2002) Cervical Kyphosis. Tech Orthop 17:345–354. https://doi.org/10.1097/00013611-200209000-00010

    Article  Google Scholar 

  45. Germain DP (2002) Clinical and genetic features of vascular Ehlers-Danlos syndrome. Ann Vasc Surg 16:391–397. https://doi.org/10.1007/s10016-001-0229-y

    Article  PubMed  Google Scholar 

  46. Giampietro PF, Raggio CL, Blank RD, McCarty C, Broeckel U, Pickart MA (2012) Clinical, genetic and environmental factors associated with congenital vertebral malformations. Mol Syndromol. https://doi.org/10.1159/000345329

    Article  PubMed Central  Google Scholar 

  47. Golightly YM, Marshall SW, Callahan LF, Guskiewicz K (2009) Early-onset arthritis in retired national football league players. J Phys Act Health 6:638–643. https://doi.org/10.1123/jpah.6.5.638

    Article  PubMed  Google Scholar 

  48. Gondar R, Nouri A, Jannelli G, Schaller K, Tessitore E (2020) Does spondylolisthesis affect severity and outcome of degenerative cervical myelopathy? A systematic review and meta-analysis.Glob Spine J 219256822096045.https://doi.org/10.1177/2192568220960452

  49. de Graaf G, Buckley F, Skotko BG (2015) Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States. Am J Med Genet A 167:756–767. https://doi.org/10.1002/ajmg.a.37001

    Article  Google Scholar 

  50. Grisdela P, Buser Z, D’Oro A, Paholpak P, Liu JC, Wang JC (2017) Trends analysis of surgical procedures for cervical degenerative disc disease and myelopathy in patients with tobacco use disorder. Eur Spine J 26:2386–2392. https://doi.org/10.1007/s00586-017-5120-9

    Article  PubMed  Google Scholar 

  51. Grodzinski B, Durham R, Mowforth O, Stubbs D, Kotter MRN, Davies BM (2020) The effect of ageing on presentation, management and outcomes in degenerative cervical myelopathy: a systematic review. Age and Ageing afaa236. https://doi.org/10.1093/ageing/afaa236

  52. Gruber J, Saleh A, Bakhsh W, Rubery PT, Mesfin A (2018) The prevalence of Klippel-Feil syndrome: a computed tomography–based analysis of 2,917 patients. Spine Deformity 6:448–453. https://doi.org/10.1016/j.jspd.2017.12.002

    Article  PubMed  Google Scholar 

  53. Grunhagen T, Shirazi-Adl A, Fairbank JCT, Urban JPG (2011) Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites. Orthop Clin North Am 42:465–477. https://doi.org/10.1016/j.ocl.2011.07.010

    Article  PubMed  Google Scholar 

  54. Guo JJ, Luk KDK, Karppinen J, Yang H, Cheung KMC (2010) Prevalence, distribution, and morphology of ossification of the ligamentum flavum: a population study of one thousand seven hundred thirty-six magnetic resonance imaging scans. Spine 35:51–56. https://doi.org/10.1097/BRS.0b013e3181b3f779

    Article  CAS  PubMed  Google Scholar 

  55. Hagenah JM, Vieregge A, Vieregge P (2001) Radiculopathy and myelopathy in patients with primary cervical dystonia. Eur Neurol 45:236–240. https://doi.org/10.1159/000052135

    Article  CAS  PubMed  Google Scholar 

  56. Han K, Lu C, Li J, Xiong G-Z, Wang B, Lv G-H, Deng Y-W (2011) Surgical treatment of cervical kyphosis. Eur Spine J 20:523–536. https://doi.org/10.1007/s00586-010-1602-8

    Article  PubMed  Google Scholar 

  57. Hayashi T, Wang JC, Suzuki A, Takahashi S, Scott TP, Phan K, Lord EL, Ruangchainikom M, Shiba K, Daubs MD (2014) Risk factors for missed dynamic canal stenosis in the cervical spine. Spine 39:812–819. https://doi.org/10.1097/BRS.0000000000000289

    Article  PubMed  Google Scholar 

  58. Henderson FC, Austin C, Benzel E, Bolognese P, Ellenbogen R, Francomano CA, Ireton C, Klinge P, Koby M, Long D, Patel S, Singman EL, Voermans NC (2017) Neurological and spinal manifestations of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet 175:195–211. https://doi.org/10.1002/ajmg.c.31549

    Article  PubMed  Google Scholar 

  59. Henderson Sr FC, Benzel EC, Vaccaro AR (2010) 20 pathophysiology of cervical myelopathy: biomechanics and deformative stress

  60. Henneton P, Legrand A, Giunta C, Frank M (2018) Arterial fragility in kyphoscoliotic Ehlers-Danlos syndrome. BMJ Case Reports bcr-2018–224423. https://doi.org/10.1136/bcr-2018-224423

  61. Hukuda S, Xiang LF, Imai S, Katsuura A, Imanaka T (1996) Large vertebral body, in addition to narrow spinal canal, are risk factors for cervical myelopathy. J Spinal Disord 9:177–186

    Article  CAS  Google Scholar 

  62. Iwasaki Y, Akino M, Abe H, Tsuru M, Tashiro K, Miyasaka K, Kaneda K, Isu T, Ito T (1983) Calcification of the ligamentum flavum of the cervical spine. J Neurosurg 59:531–534. https://doi.org/10.3171/jns.1983.59.3.0531

    Article  CAS  PubMed  Google Scholar 

  63. Jacobs LJ, Vo N, Kang JD (2011) Identifying inflammatory targets for biologic therapies for spine pain. PM&R 3:S12–S17. https://doi.org/10.1016/j.pmrj.2011.05.003

    Article  Google Scholar 

  64. Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79:368–376. https://doi.org/10.1136/jnnp.2007.131045

    Article  CAS  PubMed  Google Scholar 

  65. Jankovic J, Leder S, Warner D, Schwartz K (1991) Cervical dystonia: clinical findings and associated movement disorders. Neurology 41:1088–1088. https://doi.org/10.1212/WNL.41.7.1088

    Article  CAS  PubMed  Google Scholar 

  66. Janssen I, Nouri A, Tessitore E, Meyer B (2020) Cervical myelopathy in patients suffering from rheumatoid arthritis—a case series of 9 patients and a review of the literature. J Clin Med 9:811. https://doi.org/10.3390/jcm9030811

    Article  PubMed Central  Google Scholar 

  67. Jiang S-D, Jiang L-S, Dai L-Y (2011) Degenerative cervical spondylolisthesis: a systematic review. Int Orthop 35:869–875. https://doi.org/10.1007/s00264-010-1203-5

    Article  PubMed  PubMed Central  Google Scholar 

  68. Johnston SL, Campbell MR, Scheuring R, Feiveson AH (2010) Risk of herniated nucleus pulposus among U.S. astronauts. Aviat Space Environ Med 81:566–574. https://doi.org/10.3357/ASEM.2427.2010

    Article  PubMed  Google Scholar 

  69. Jumah KB, Nyame PK (1994) Relationship between load carrying on the head and cervical spondylosis in Ghanaians. West Afr J Med 13:181–182

    CAS  PubMed  Google Scholar 

  70. Kadow T, Sowa G, Vo N, Kang JD (2015) Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions? Clin Orthop Relat Res 473:1903–1912. https://doi.org/10.1007/s11999-014-3774-8

    Article  PubMed  Google Scholar 

  71. Karadimas SK, Erwin WM, Ely CG, Dettori JR, Fehlings MG (2013) Pathophysiology and natural history of cervical spondylotic myelopathy. Spine 38:S21–S36. https://doi.org/10.1097/BRS.0b013e3182a7f2c3

    Article  PubMed  Google Scholar 

  72. Kato F, Yukawa Y, Suda K, Yamagata M, Ueta T (2012) Normal morphology, age-related changes and abnormal findings of the cervical spine. Part II: magnetic resonance imaging of over 1,200 asymptomatic subjects. Eur Spine J 21:1499–1507. https://doi.org/10.1007/s00586-012-2176-4

    Article  PubMed  PubMed Central  Google Scholar 

  73. Kawasaki M, Tani T, Ushida T, Ishida K (2007) Anterolisthesis and retrolisthesis of the cervical spine in cervical spondylotic myelopathy in the elderly. J Orthop Sci 12:207–213. https://doi.org/10.1007/s00776-007-1122-5

    Article  PubMed  Google Scholar 

  74. Kimura A, Takeshita K, Yoshii T, Egawa S, Hirai T, Sakai K, Kusano K, Nakagawa Y, Wada K, Katsumi K, Fujii K, Furuya T, Nagoshi N, Kanchiku T, Nagamoto Y, Oshima Y, Nakashima H, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Watanabe K, Imagama S, Koda M, Kawaguchi Y, Nakamura M, Matsumoto M, Yamazaki M, Okawa A (2021) Impact of diabetes mellitus on cervical spine surgery for ossification of the posterior longitudinal ligament. JCM 10:3375. https://doi.org/10.3390/jcm10153375

    Article  PubMed  PubMed Central  Google Scholar 

  75. Klippel M, Feil A (1912) Un cas d’absence des vertébres cervicales cage thoracique remontant jusqu’a la base du crâne. Bull Mémoir Soc d’anthropol Paris 3:101–102. https://doi.org/10.3406/bmsap.1912.8505

    Article  Google Scholar 

  76. Kobashi G, Washio M, Okamoto K, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Ohta K, Inaba Y, Tanaka H (2004) High body mass index after age 20 and diabetes mellitus are independent risk factors for ossification of the posterior longitudinal ligament of the spine in Japanese subjects: a case-control study in multiple hospitals. Spine 29:1006–1010. https://doi.org/10.1097/00007632-200405010-00011

    Article  PubMed  Google Scholar 

  77. Kokubun S, Sato T, Ishii Y, Tanaka Y (1996) Cervical myelopathy in the Japanese. Clin Orthop Relat Res 323:129–138. https://doi.org/10.1097/00003086-199602000-00018

    Article  Google Scholar 

  78. Konrad C, Vollmer-Haase J, Anneken K, Knecht S (2004) Orthopedic and neurological complications of cervical dystonia - review of the literature. Acta Neurol Scand 109:369–373. https://doi.org/10.1111/j.1600-0404.2004.00281.x

    Article  CAS  PubMed  Google Scholar 

  79. Kovalova I, Kerkovsky M, Kadanka Z, Kadanka Z, Nemec M, Jurova B, Dusek L, Jarkovsky J, Bednarik J (2016) Prevalence and imaging characteristics of nonmyelopathic and myelopathic spondylotic cervical cord compression. Spine 41:1908–1916. https://doi.org/10.1097/BRS.0000000000001842

    Article  PubMed  Google Scholar 

  80. Koyanagi I, Iwasaki Y, Hida K, Imamura H, Abe H (1998) Magnetic resonance imaging findings in ossification of the posterior longitudinal ligament of the cervical spine. J Neurosurg 88:247–254. https://doi.org/10.3171/jns.1998.88.2.0247

    Article  CAS  PubMed  Google Scholar 

  81. Krauss JK, Jankovic J (1996) Severe motor tics causing cervical myelopathy in Tourette’s syndrome. Mov Disord 11:563–566. https://doi.org/10.1002/mds.870110512

    Article  CAS  PubMed  Google Scholar 

  82. Kumar H, Boban M, Tiwari M (2009) Skeletal fluorosis causing high cervical myelopathy. J Clin Neurosci 16:828–830. https://doi.org/10.1016/j.jocn.2008.08.028

    Article  PubMed  Google Scholar 

  83. Kusin DJ, Li SQ, Ahn UM, Ahn NU (2016) Does tobacco use attenuate benefits of early decompression in patients with cervical myelopathy? Spine 41:1565–1569. https://doi.org/10.1097/BRS.0000000000001597

    Article  PubMed  Google Scholar 

  84. de Lau LM, Breteler MM (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5:525–535. https://doi.org/10.1016/S1474-4422(06)70471-9

    Article  PubMed  Google Scholar 

  85. Lawrence BD, Hilibrand AS, Brodt ED, Dettori JR, Brodke DS (2012) Predicting the risk of adjacent segment pathology in the cervical spine: a systematic review. Spine 37:S52–S64. https://doi.org/10.1097/BRS.0b013e31826d60fb

    Article  PubMed  Google Scholar 

  86. Lee MJ, Cassinelli EH, Riew KD (2007) Prevalence of cervical spine stenosis: anatomic study in cadavers. J Bone Joint Surg 89:376–380. https://doi.org/10.2106/JBJS.F.00437

    Article  PubMed  Google Scholar 

  87. Liu M, Tan Y, Zhang C, He L (2021) Cortical anatomy plasticity in cases of cervical spondylotic myelopathy associated with decompression surgery: a strobe-compliant study of structural magnetic resonance imaging. Medicine 100:e24190. https://doi.org/10.1097/MD.0000000000024190

    Article  PubMed  PubMed Central  Google Scholar 

  88. Maclachlan RA, Fidler KE, Yeh H, Hodgetts PG, Pharand G, Chau M (2008) Cervical spine abnormalities in institutionalized adults with Down’s syndrome. J Intellect Disabil Res 37:277–285. https://doi.org/10.1111/j.1365-2788.1993.tb01284.x

    Article  Google Scholar 

  89. Mallory GW, Halasz SR, Clarke MJ (2014) Advances in the treatment of cervical rheumatoid: less surgery and less morbidity. World J Orthop 5:292–303. https://doi.org/10.5312/wjo.v5.i3.292

    Article  PubMed  PubMed Central  Google Scholar 

  90. Mao J-R, Bristow J (2001) The Ehlers-Danlos syndrome: on beyond collagens. J Clin Investig 107:1063–1069. https://doi.org/10.1172/JCI12881

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Martini ML, Deutsch BC, Neifert SN, Caridi JM (2019) A national snapshot detailing the impact of Parkinson’s disease on the cost and outcome profiles of fusion procedures for cervical myelopathy. Neurosurgery. https://doi.org/10.1093/neuros/nyz087

    Article  Google Scholar 

  92. Matsunaga S, Komiya S, Toyama Y (2015) Risk factors for development of myelopathy in patients with cervical spondylotic cord compression. Eur Spine J 24:142–149. https://doi.org/10.1007/s00586-013-2839-9

    Article  PubMed  Google Scholar 

  93. Matsunaga S, Kukita M, Hayashi K, Shinkura R, Koriyama C, Sakou T, Komiya S (2002) Pathogenesis of myelopathy in patients with ossification of the posterior longitudinal ligament. J Neurosurg Spine 96:168–172. https://doi.org/10.3171/spi.2002.96.2.0168

    Article  Google Scholar 

  94. Matur AV, Nouri A, Huang S, Elson NC, Jeong W, Bierbrauer KS, Mangano FT, Cheng JS (2020) Complications in children with Ehlers-Danlos syndrome following spine surgery: analysis of the pediatric national surgery quality improvement program database. World Neurosurg 133:e473–e478. https://doi.org/10.1016/j.wneu.2019.09.046

    Article  PubMed  Google Scholar 

  95. McGaughran JM, Kuna P, Das V (1998) Audiological abnormalities in the Klippel-Feil syndrome. Arch Dis Child 79:352–355. https://doi.org/10.1136/adc.79.4.352

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Menger R, Wolf M, Thakur JD, Nanda A, Martino A (2019) Astronaut Michael Collins, Apollo 8, and the anterior cervical fusion that changed the history of human spaceflight. J Neurosurg Spine 31:87–92. https://doi.org/10.3171/2018.11.SPINE18629

    Article  PubMed  Google Scholar 

  97. Milhorat TH, Bolognese PA, Nishikawa M, McDonnell NB, Francomano CA (2007) Syndrome of occipitoatlantoaxial hypermobility, cranial settling, and Chiari malformation Type I in patients with hereditary disorders of connective tissue. J Neurosurg Spine 7:601–609. https://doi.org/10.3171/SPI-07/12/601

    Article  PubMed  Google Scholar 

  98. Miyasaka K, Kaneda K, Sato S, Iwasaki Y, Abe S, Takei H, Tsuru M, Tashiro K, Abe H, Fujioka Y (1983) Myelopathy due to ossification or calcification of the ligamentum flavum: radiologic and histologic evaluations. AJNR Am J Neuroradiol 4:629–632

    CAS  PubMed  PubMed Central  Google Scholar 

  99. Mobbs RJ, Dvorak M (2007) Ossification of the ligamentum flavum: diet and genetics. J Clin Neurosci 14:703–705. https://doi.org/10.1016/j.jocn.2006.01.010

    Article  PubMed  Google Scholar 

  100. Moon BJ, Smith JS, Ames CP, Shaffrey CI, Lafage V, Schwab F, Matsumoto M, Baik JS, Ha Y (2016) Prevalence and type of cervical deformities among adults with Parkinson’s disease: a cross-sectional study. SPI 24:527–534. https://doi.org/10.3171/2015.6.SPINE141197

    Article  Google Scholar 

  101. Moore WB, Matthews TJ, Rabinowitz R (1975) Genitourinary anomalies associated with Klippel-Feil syndrome. J Bone Joint Surg Am 57:355–357

    Article  CAS  Google Scholar 

  102. Mori K, Imai S, Kasahara T, Nishizawa K, Mimura T, Matsusue Y (2014) Prevalence, distribution, and morphology of thoracic ossification of the posterior longitudinal ligament in Japanese: results of CT-based cross-sectional study. Spine 39:394–399. https://doi.org/10.1097/BRS.0000000000000153

    Article  PubMed  Google Scholar 

  103. Morishita Y, Naito M, Hymanson H, Miyazaki M, Wu G, Wang JC (2009) The relationship between the cervical spinal canal diameter and the pathological changes in the cervical spine. Eur Spine J 18:877–883. https://doi.org/10.1007/s00586-009-0968-y

    Article  PubMed  PubMed Central  Google Scholar 

  104. Nagoshi N, Watanabe K, Nakamura M, Matsumoto M, Li N, Ma S, He D, Tian W, Jeon H, Lee JJ, Kim KN, Ha Y, Hong Kwan KY, Po Cheung AK (2021) Does diabetes affect the surgical outcomes in cases with cervical ossification of the posterior longitudinal ligament? A multicenter study from Asia Pacific spine study group.Glob Spine J 219256822199630.https://doi.org/10.1177/2192568221996300

  105. Nakashima H, Yukawa Y, Suda K, Yamagata M, Ueta T, Kato F (2016) Relatively large cervical spinal cord for spinal canal is a risk factor for development of cervical spinal cord compression: a cross-sectional study of 1211 subjects. Spine 41:E342–E348. https://doi.org/10.1097/BRS.0000000000001255

    Article  PubMed  Google Scholar 

  106. Nam DC, Lee HJ, Lee CJ, Hwang S-C (2019) Molecular pathophysiology of ossification of the posterior longitudinal ligament (OPLL). Biomol Ther 27:342–348. https://doi.org/10.4062/biomolther.2019.043

    Article  Google Scholar 

  107. Neo M (2008) Treatment of upper cervical spine involvement in rheumatoid arthritis patients. Mod Rheumatol 18:327–335. https://doi.org/10.1007/s10165-008-0059-7

    Article  PubMed  Google Scholar 

  108. Nicholson KJ, Millhouse PW, Pflug E, Woods B, Schroeder GD, Anderson DG, Hilibrand AS, Kepler CK, Kurd MF, Rihn JA, Vaccaro A, Radcliff KE (2018) Cervical sagittal range of motion as a predictor of symptom severity in cervical spondylotic myelopathy. Spine 43:883–889. https://doi.org/10.1097/BRS.0000000000002478

    Article  PubMed  Google Scholar 

  109. Nouri A, Fehlings MG (2017) Diffuse idiopathic skeletal hyperostosis with cervical myelopathy. CMAJ 189:E410–E410. https://doi.org/10.1503/cmaj.160487

    Article  PubMed  PubMed Central  Google Scholar 

  110. Nouri A, Kato S, Badhiwala JH, Robinson M, Mejia Munne J, Yang G, Jeong W, Nasser R, Gimbel DA, Cheng JS, Fehlings MG (2020) The influence of cervical spondylolisthesis on clinical presentation and surgical outcome in patients with DCM: analysis of a multicenter global cohort of 458 patients. Glob Spine J 10:448–455. https://doi.org/10.1177/2192568219860827

    Article  Google Scholar 

  111. Nouri A, Martin AR, Lange SF, Kotter MRN, Mikulis DJ, Fehlings MG (2017) Congenital cervical fusion as a risk factor for development of degenerative cervical myelopathy. World Neurosurg 100:531–539. https://doi.org/10.1016/j.wneu.2017.01.048

    Article  PubMed  Google Scholar 

  112. Nouri A, Martin AR, Tetreault L, Nater A, Kato S, Nakashima H, Nagoshi N, Reihani-Kermani H, Fehlings MG (2017) MRI analysis of the combined prospectively collected AOSpine North America and International Data: the prevalence and spectrum of pathologies in a global cohort of patients with degenerative cervical myelopathy. Spine 42:1058–1067. https://doi.org/10.1097/BRS.0000000000001981

    Article  PubMed  Google Scholar 

  113. Nouri A, Montejo J, Sun X, Virojanapa J, Kolb LE, Abbed KM, Cheng JS (2017) Cervical cord-canal mismatch: a new method for identifying predisposition to spinal cord injury. World Neurosurg 108:112–117. https://doi.org/10.1016/j.wneu.2017.08.018

    Article  PubMed  Google Scholar 

  114. Nouri A, Patel K, Evans H, Saleh M, Kotter MRN, Heary RF, Tessitore E, Fehlings MG, Cheng JS (2019) Demographics, presentation and symptoms of patients with Klippel-Feil syndrome: analysis of a global patient-reported registry. Eur Spine J 28:2257–2265. https://doi.org/10.1007/s00586-019-06084-0

    Article  PubMed  Google Scholar 

  115. Nouri A, Tetreault L, Nori S, Martin AR, Nater A, Fehlings MG (2018) Congenital cervical spine stenosis in a multicenter global cohort of patients with degenerative cervical myelopathy: an ambispective report based on a magnetic resonance imaging diagnostic criterion. Neurosurgery 83:521–528. https://doi.org/10.1093/neuros/nyx521

    Article  PubMed  Google Scholar 

  116. Nouri A, Tetreault L, Singh A, Karadimas SK, Fehlings MG (2015) Degenerative cervical myelopathy: epidemiology, genetics, and pathogenesis. Spine 40:E675–E693. https://doi.org/10.1097/BRS.0000000000000913

    Article  PubMed  Google Scholar 

  117. Nurick S (1972) The pathogenesis of the spinal cord disorder associated with cervical spondylosis. Brain 95:87–100

    Article  CAS  Google Scholar 

  118. Nussbaum RL, McInnes RR, Willard HF (2015) Thompson & Thompson genetics in medicine e-book. Elsevier Health Sciences

  119. Oda T, Ochi T, Fujiwara K, Yonenobu K, Azuma B (1995) Natural course of cervical spine lesions in rheumatoid arthritis. Spine 20:1128–1135. https://doi.org/10.1097/00007632-199505150-00004

    Article  CAS  PubMed  Google Scholar 

  120. Oh JK, Smith JS, Shaffrey CI, Lafage V, Schwab F, Ames CP, Matsumoto M, Baik JS, Ha Y (2014) Sagittal spinopelvic malalignment in Parkinson disease: prevalence and associations with disease severity. Spine 39:E833–E841. https://doi.org/10.1097/BRS.0000000000000366

    Article  PubMed  Google Scholar 

  121. Oh JY-L, Wang VT-J, Teo TWW, Kaliya-Perumal A-K, Hee HT (2019) Ossification of the yellow ligament in the cervical spine – an unusual location. Biomedicine 9:14. https://doi.org/10.1051/bmdcn/2019090214

    Article  PubMed  PubMed Central  Google Scholar 

  122. Okamoto K, Kobashi G, Washio M, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Ohta K, Inaba Y, Tanaka H, the Japan Collaborative Epidemiological Study Group for Evaluation of Ossification of the Posterior Longitudinal Ligament of the Spine (OPLL) Risk (2004) Dietary habits and risk of ossification of the posterior longitudinal ligaments of the spine (OPLL); findings from a case-control study in Japan. J Bone Miner Metab 22:612–617. https://doi.org/10.1007/s00774-004-0531-1

    Article  PubMed  Google Scholar 

  123. Olive PM, Whitecloud TS, Bennett JT (1988) Lower cervical spondylosis and myelopathy in adults with Downʼs syndrome. Spine 13:781–784. https://doi.org/10.1097/00007632-198807000-00012

    Article  CAS  PubMed  Google Scholar 

  124. Omura K, Hukuda S, Matsumoto K, Katsuura A, Nishioka J, Imai S (1996) Cervical myelopathy caused by calcium pyrophosphate dihydrate crystal deposition in facet joints: a case report. Spine 21:2372–2375. https://doi.org/10.1097/00007632-199610150-00014

    Article  CAS  PubMed  Google Scholar 

  125. Pizzutillo PD, Woods M, Nicholson L, MacEwen GD (1994) Risk factors in Klippel-Feil syndrome. Spine 19:2110–2116. https://doi.org/10.1097/00007632-199409150-00020

    Article  CAS  PubMed  Google Scholar 

  126. Rafii MS, Kleschevnikov AM, Sawa M, Mobley WC (2019) Down syndrome. In: Handbook of Clinical Neurology. Elsevier, pp 321–336

  127. Reboursiere E, Bohu Y, Retière D, Sesboüé B, Pineau V, Colonna JP, Hager JP, Peyrin JC, Piscione J (2018) Impact of the national prevention policy and scrum law changes on the incidence of rugby-related catastrophic cervical spine injuries in French Rugby Union. Br J Sports Med 52:674–677. https://doi.org/10.1136/bjsports-2016-096122

    Article  CAS  PubMed  Google Scholar 

  128. Samartzis D, Herman J, Lubicky JP, Shen FH (2006) Classification of congenitally fused cervical patterns in Klippel-Feil patients: epidemiology and role in the development of cervical spine-related symptoms. Spine 31:E798–E804. https://doi.org/10.1097/01.brs.0000239222.36505.46

    Article  PubMed  Google Scholar 

  129. Sawada T, Kishiya M, Kanemaru K, Seya K, Yokoyama T, Ueyama K, Motomura S, Toh S, Furukawa K-I (2008) Possible role of extracellular nucleotides in ectopic ossification of human spinal ligaments. J Pharmacol Sci 106:152–161. https://doi.org/10.1254/jphs.FP0071224

    Article  CAS  PubMed  Google Scholar 

  130. Sayit E, Daubs MD, Aghdasi B, Montgomery SR, Inoue H, Wang CJ, Wang BJ, Phan KH, Scott TP (2013) Dynamic changes of the ligamentum flavum in the cervical spine assessed with kinetic magnetic resonance imaging. Glob Spine J 3:69–73. https://doi.org/10.1055/s-0033-1337121

    Article  CAS  Google Scholar 

  131. Scheer JK, Tang JA, Smith JS, Acosta FL, Protopsaltis TS, Blondel B, Bess S, Shaffrey CI, Deviren V, Lafage V, Schwab F, Ames CP (2013) Cervical spine alignment, sagittal deformity, and clinical implications: a review. SPI 19:141–159. https://doi.org/10.3171/2013.4.SPINE12838

    Article  Google Scholar 

  132. Scher AT (1998) Rugby injuries to the cervical spine and spinal cord. Clin Sports Med 17:195–206. https://doi.org/10.1016/S0278-5919(05)70073-9

    Article  CAS  PubMed  Google Scholar 

  133. Schroeder GD, Lynch TS, Gibbs DB, Chow I, LaBelle MW, Patel AA, Savage JW, Nuber GW, Hsu WK (2014) The impact of a cervical spine diagnosis on the careers of National Football League athletes. Spine 39:947–952. https://doi.org/10.1097/BRS.0000000000000321

    Article  PubMed  Google Scholar 

  134. Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. The Lancet 376:1094–1108. https://doi.org/10.1016/S0140-6736(10)60826-4

    Article  Google Scholar 

  135. Sencan D, Elden H, Nacitarhan V, Sencan M, Kaptanoglu E (2005) The prevalence of diffuse idiopathic skeletal hyperostosis in patients with diabetes mellitus. Rheumatol Int 25:518–521. https://doi.org/10.1007/s00296-004-0474-9

    Article  CAS  PubMed  Google Scholar 

  136. Shlobin NA, Dahdaleh NS (2020) Cervical spine manifestations of rheumatoid arthritis: a review. Neurosurg Rev. https://doi.org/10.1007/s10143-020-01412-1

    Article  PubMed  Google Scholar 

  137. Singh A, Tetreault L, Fehlings M, Fischer D, Skelly A (2013) Risk factors for development of cervical spondylotic myelopathy: results of a systematic review. Evid Based Spine Care J 3:35–42. https://doi.org/10.1055/s-0032-1327808

    Article  CAS  Google Scholar 

  138. Smith JS, Lafage V, Ryan DJ, Shaffrey CI, Schwab FJ, Patel AA, Brodke DS, Arnold PM, Riew KD, Traynelis VC, Radcliff K, Vaccaro AR, Fehlings MG, Ames CP (2013) Association of myelopathy scores with cervical sagittal balance and normalized spinal cord volume: analysis of 56 preoperative cases from the AOSpine North America myelopathy study. Spine 38:S161–S170. https://doi.org/10.1097/BRS.0b013e3182a7eb9e

    Article  PubMed  Google Scholar 

  139. Soehle M, Casey ATH (2002) Cervical spinal cord compression attributable to a calcified intervertebral disc in a patient with X-linked hypophosphatemic rickets: case report and review of the literature. Neurosurgery 51:239–243. https://doi.org/10.1097/00006123-200207000-00038

    Article  PubMed  Google Scholar 

  140. Sohail A, Maan MA, Khan M, Masood Q (2018) Isolated ligamentum flavum ossification in primary hypoparathyroidism. Surg Neurol Int 9:4. https://doi.org/10.4103/sni.sni_364_17

    Article  PubMed  PubMed Central  Google Scholar 

  141. Stapleton CJ, Pham MH, Attenello FJ, Hsieh PC (2011) Ossification of the posterior longitudinal ligament: genetics and pathophysiology. FOC 30:E6. https://doi.org/10.3171/2010.12.FOCUS10271

    Article  Google Scholar 

  142. Stein BE, Hassanzadeh H, Jain A, Lemma MA, Cohen DB, Kebaish KM (2014) Changing trends in cervical spine fusions in patients with rheumatoid arthritis. Spine 39:1178–1182. https://doi.org/10.1097/BRS.0000000000000376

    Article  PubMed  Google Scholar 

  143. Steinmetz MP, Stewart TJ, Kager CD, Benzel EC, Vaccaro AR (2007) Cervical deformity correction. Neurosurgery 60:S1-90-S1-97. https://doi.org/10.1227/01.NEU.0000215553.49728.B0

    Article  Google Scholar 

  144. Takamiya Y, Nagata K, Fukuda K, Shibata A, Ishitake T, Suenaga T (2006) Cervical spine disorders in farm workers requiring neck extension actions. J Orthop Sci 11:235–240. https://doi.org/10.1007/s00776-006-1005-1

    Article  PubMed  Google Scholar 

  145. Tam S, Barry RL, Bartha R, Duggal N (2010) Changes in functional magnetic resonance imaging cortical activation after decompression of cervical spondylosis. Neurosurgery 67:E863–E864. https://doi.org/10.1227/01.NEU.0000374848.86299.17

    Article  PubMed  Google Scholar 

  146. Tan Y, Zhou F, Wu L, Liu Z, Zeng X, Gong H, He L (2015) Alteration of regional homogeneity within the sensorimotor network after spinal cord decompression in cervical spondylotic myelopathy: a resting-state fMRI study. Biomed Res Int 2015:1–6. https://doi.org/10.1155/2015/647958

    Article  CAS  Google Scholar 

  147. Torg JS, Naranja RJ, Pavlov H, Galinat BJ, Warren R, Stine RA (1996) The relationship of developmental narrowing of the cervical spinal canal to reversible and irreversible injury of the cervical spinal cord in football players. An epidemiological study*. J Bone Joint Surg 78:1308–1314. https://doi.org/10.2106/00004623-199609000-00003

    Article  CAS  PubMed  Google Scholar 

  148. Tracy MR, Dormans JP, Kusumi K (2004) Klippel-Feil syndrome: clinical features and current understanding of etiology. Clin Orthop Relat Res 424:183–190. https://doi.org/10.1097/01.blo.0000130267.49895.20

    Article  Google Scholar 

  149. Triantafillou KM, Lauerman W, Kalantar SB (2012) Degenerative disease of the cervical spine and its relationship to athletes. Clin Sports Med 31:509–520. https://doi.org/10.1016/j.csm.2012.03.009

    Article  PubMed  Google Scholar 

  150. Tsuyama N (1984) Ossification of the posterior longitudinal ligament of the spine. Clin Orthop Relat Res 71–84

  151. Wang P-N, Chen S-S, Liu H-C, Fuh J-L, Kuo BI-T, Wang S-J (1999) Ossification of the posterior longitudinal ligament of the spine: a case-control risk factor study. Spine 24:142–144. https://doi.org/10.1097/00007632-199901150-00010

    Article  CAS  PubMed  Google Scholar 

  152. Wang X-R, Kwok TCY, Griffith JF, Man Yu BW, Leung JCS, Wáng YXJ (2019) Prevalence of cervical spine degenerative changes in elderly population and its weak association with aging, neck pain, and osteoporosis. Ann Transl Med 7:486. https://doi.org/10.21037/atm.2019.07.80

    Article  PubMed  PubMed Central  Google Scholar 

  153. Wang ZC, Shi JG, Chen XS, Xu GH, Li LJ, Jia LS (2012) The role of smoking status and collagen IX polymorphisms in the susceptibility to cervical spondylotic myelopathy. Genet Mol Res 11:1238–1244. https://doi.org/10.4238/2012.May.9.2

    Article  CAS  PubMed  Google Scholar 

  154. Weir DR, Jackson JS, Sonnega A (2009) National Football League player care foundation study of retired NFL players. University of Michigan Institute for Social Research, Ann Arbor

    Google Scholar 

  155. White AP, Biswas D, Smart LR, Haims A, Grauer JN (2007) Utility of flexion-extension radiographs in evaluating the degenerative cervical spine. Spine 32:975–979. https://doi.org/10.1097/01.brs.0000261409.45251.a2

    Article  PubMed  Google Scholar 

  156. Witiw CD, Tetreault LA, Smieliauskas F, Kopjar B, Massicotte EM, Fehlings MG (2017) Surgery for degenerative cervical myelopathy: a patient-centered quality of life and health economic evaluation. Spine J 17:15–25. https://doi.org/10.1016/j.spinee.2016.10.015

    Article  PubMed  Google Scholar 

  157. Wu J-C, Ko C-C, Yen Y-S, Huang W-C, Chen Y-C, Liu L, Tu T-H, Lo S-S, Cheng H (2013) Epidemiology of cervical spondylotic myelopathy and its risk of causing spinal cord injury: a national cohort study. Neurosurg Focus 35:E10. https://doi.org/10.3171/2013.4.FOCUS13122

    Article  PubMed  Google Scholar 

  158. Xiao R, Miller JA, Lubelski D, Alberts JL, Mroz TE, Benzel EC, Krishnaney AA, Machado AG (2016) Quality of life outcomes following cervical decompression for coexisting Parkinson’s disease and cervical spondylotic myelopathy. Spine J 16:1358–1366. https://doi.org/10.1016/j.spinee.2016.07.530

    Article  PubMed  Google Scholar 

  159. Xiao R, Miller JA, Lubelski D, Mroz TE, Benzel EC, Krishnaney AA, Machado A (2017) Clinical outcomes following surgical management of coexisting Parkinson disease and cervical spondylotic myelopathy. Neurosurgery 81:350–356. https://doi.org/10.1093/neuros/nyw043

    Article  PubMed  Google Scholar 

  160. Xue X, Shen J, Zhang J, Tian Y, Zhao H, Wang Y, Liang J, Li Z, Qiu G (2014) Klippel-Feil syndrome in congenital scoliosis. Spine 39:E1353–E1358. https://doi.org/10.1097/BRS.0000000000000587

    Article  PubMed  Google Scholar 

  161. Yang C-Y, Wang J-C (2017) An unusual case of rapidly progressed cervical compression myelopathy caused by overnight inappropriate usage of Smartphone device. J Clin Neurosci 39:82–84. https://doi.org/10.1016/j.jocn.2016.12.050

    Article  PubMed  Google Scholar 

  162. Yang JS, Sponseller PD, Yazici M, Johnston CE (2009) Vascular complications from anterior spine surgery in three patients with Ehlers-Danlos syndrome. Spine 34:E153–E157. https://doi.org/10.1097/BRS.0b013e31818d58da

    Article  PubMed  Google Scholar 

  163. Yarbrough CK, Murphy RKJ, Ray WZ, Stewart TJ (2012) The natural history and clinical presentation of cervical spondylotic myelopathy. Adv Orthop 2012:1–4. https://doi.org/10.1155/2012/480643

    Article  Google Scholar 

  164. Yen H-L, Cheng C-H, Lin J-W (2002) Cervical myelopathy due to gouty tophi in the intervertebral disc space. Acta Neurochir (Wien) 144:205–207. https://doi.org/10.1007/s007010200026

    Article  PubMed  Google Scholar 

  165. Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T (2014) Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: a 3-year follow-up of the ROAD study. Osteoporos Int 25:1089–1098. https://doi.org/10.1007/s00198-013-2489-0

    Article  CAS  PubMed  Google Scholar 

  166. Yu W-R, Baptiste DC, Liu T, Odrobina E, Stanisz GJ, Fehlings MG (2009) Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy. Neurobiol Dis 33:149–163. https://doi.org/10.1016/j.nbd.2008.09.024

    Article  CAS  PubMed  Google Scholar 

  167. Yue WM, Tan SB, Tan MH, Koh DC, Tan CT (2001) The Torg-Pavlov ratio in cervical spondylotic myelopathy: a comparative study between patients with cervical spondylotic myelopathy and a nonspondylotic, nonmyelopathic population. Spine 26:1760–1764

    Article  CAS  Google Scholar 

  168. Zdunczyk A, Schwarzer V, Mikhailov M, Bagley B, Rosenstock T, Picht T, Vajkoczy P (2018) The corticospinal reserve capacity: reorganization of motor area and excitability as a novel pathophysiological concept in cervical myelopathy. Neurosurgery 83:810–818. https://doi.org/10.1093/neuros/nyx437

    Article  PubMed  Google Scholar 

  169. Zevin S, Gourlay SG, Benowitz NL (1998) Clinical pharmacology of nicotine. Clin Dermatol 16:557–564. https://doi.org/10.1016/s0738-081x(98)00038-8

    Article  CAS  PubMed  Google Scholar 

  170. Zikou AK, Alamanos Y, Argyropoulou MI, Tsifetaki N, Tsampoulas C, Voulgari PV, Efremidis SC, Drosos AA (2005) Radiological cervical spine involvement in patients with rheumatoid arthritis: a cross sectional study. J Rheumatol 32:801–806

    PubMed  Google Scholar 

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  1. Neurosurgical Unit, Geneva University Hospital, Geneva, Switzerland

    Guillaume Baucher, Jelena Taskovic, Granit Molliqaj, Aria Nouri & Enrico Tessitore

  2. AP-HM, Hôpital Universitaire Nord, Neurochirurgie adulte, Chemin Des Bourrely, 13015, Marseille, France

    Guillaume Baucher & Lucas Troude

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Baucher, G., Taskovic, J., Troude, L. et al. Risk factors for the development of degenerative cervical myelopathy: a review of the literature. Neurosurg Rev 45, 1675–1689 (2022). https://doi.org/10.1007/s10143-021-01698-9

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